IL154520A0 - Human coagulation factor vii variants - Google Patents

Human coagulation factor vii variants

Info

Publication number
IL154520A0
IL154520A0 IL15452001A IL15452001A IL154520A0 IL 154520 A0 IL154520 A0 IL 154520A0 IL 15452001 A IL15452001 A IL 15452001A IL 15452001 A IL15452001 A IL 15452001A IL 154520 A0 IL154520 A0 IL 154520A0
Authority
IL
Israel
Prior art keywords
factor vii
coagulation factor
human coagulation
vii variants
variants
Prior art date
Application number
IL15452001A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26068878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL154520(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL154520A0 publication Critical patent/IL154520A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
IL15452001A 2000-09-13 2001-09-13 Human coagulation factor vii variants IL154520A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200001361 2000-09-13
US23645500P 2000-09-29 2000-09-29
PCT/DK2001/000596 WO2002022776A2 (en) 2000-09-13 2001-09-13 Human coagulation factor vii variants

Publications (1)

Publication Number Publication Date
IL154520A0 true IL154520A0 (en) 2003-09-17

Family

ID=26068878

Family Applications (4)

Application Number Title Priority Date Filing Date
IL15452001A IL154520A0 (en) 2000-09-13 2001-09-13 Human coagulation factor vii variants
IL154520A IL154520A (en) 2000-09-13 2003-02-18 Variable versions of coagulation factor of human origin, method of preparation and pharmaceutical preparations containing them
IL196482A IL196482A (en) 2000-09-13 2009-01-13 Variable versions of coagulation factor of human origin, method of preparation and pharmaceutical preparations containing them
IL206229A IL206229A (en) 2000-09-13 2010-06-07 Variants of coagulation factor VII of human origin and pharmaceutical preparations containing them for the treatment of hemorrhagic obstruction disorders

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL154520A IL154520A (en) 2000-09-13 2003-02-18 Variable versions of coagulation factor of human origin, method of preparation and pharmaceutical preparations containing them
IL196482A IL196482A (en) 2000-09-13 2009-01-13 Variable versions of coagulation factor of human origin, method of preparation and pharmaceutical preparations containing them
IL206229A IL206229A (en) 2000-09-13 2010-06-07 Variants of coagulation factor VII of human origin and pharmaceutical preparations containing them for the treatment of hemorrhagic obstruction disorders

Country Status (7)

Country Link
EP (3) EP2253703A1 (de)
JP (2) JP4361728B2 (de)
AU (2) AU2001287550B2 (de)
HU (1) HUP0301246A3 (de)
IL (4) IL154520A0 (de)
PL (1) PL204888B1 (de)
WO (1) WO2002022776A2 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
EP2319541A1 (de) 2000-02-11 2011-05-11 Bayer HealthCare LLC Faktor VII- oder VIIA-ähnliche Konjugate
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
RU2326126C2 (ru) 2000-09-13 2008-06-10 Ново Нордиск Хелт Кэр Аг Полипептид фактора vii свертывания крови, его получение и применение
WO2002038162A1 (en) 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
ES2432967T3 (es) * 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
KR20040015821A (ko) * 2001-07-20 2004-02-19 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인자 ⅶ 폴리펩티드와 인자 ⅹⅰ폴리펩티드를 포함하는약학적 조성물
US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
ES2490590T3 (es) * 2001-11-02 2014-09-04 Novo Nordisk Health Care Ag Polipéptidos de factor VII de coagulación humana
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US7125846B2 (en) 2001-11-09 2006-10-24 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
AU2002351756A1 (en) 2001-12-21 2003-07-15 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
AU2003221469A1 (en) 2002-04-30 2003-11-17 Bayer Healthcare Llc FACTOR VII OR VIIa POLYPEPTIDE VARIANTS
CA2490342C (en) 2002-06-21 2015-06-16 Novo Nordisk A/S Stabilised solid compositions of factor vii polypeptides
UA86744C2 (en) 2002-06-21 2009-05-25 Ново Нордиск Хэлс Кеа Аг Pegylated factor vii glycoforms
AU2003266214A1 (en) 2002-09-25 2004-04-19 Novo Nordisk A/S Human coagulation factor vii polypeptides
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
RU2364626C2 (ru) * 2003-03-18 2009-08-20 Ново Нордиск Хелт Кэр Аг Способ получения, способ очистки и способ стабилизации полипептидов фактора vii, ix и x
EP2085470B1 (de) * 2003-03-20 2012-05-16 Bayer HealthCare LLC FVII oder FVIIa Varianten
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
CN1771080B (zh) 2003-04-08 2010-12-15 诺沃挪第克公司 包括至少一个色谱处理步骤的生产治疗用多肽或其前体的方法
AU2004247799B2 (en) 2003-06-19 2009-12-03 Bayer Healthcare Llc Factor VII or VIIa Gla domain variants
EP1641487B1 (de) 2003-06-25 2012-02-29 Novo Nordisk Health Care AG Flüssige zusammensetzungen von factor vii polypeptiden
ATE547519T1 (de) 2003-09-09 2012-03-15 Novo Nordisk Healthcare Ag Gerinnungsfaktor-vii-polypeptide
EP1673453A2 (de) 2003-10-07 2006-06-28 Novo Nordisk Health Care AG Hybridmoleküle mit faktor vii/viia-aktivität
PL1711513T3 (pl) 2003-12-01 2014-12-31 Novo Nordisk Healthcare Ag Nanofiltracja roztworów czynnika vii w celu usunięcia wirusów
DK2298287T3 (en) 2003-12-19 2018-07-23 Novo Nordisk Healthcare Ag Stabilized compositions of factor VII polypeptides
DK2842576T3 (en) 2004-01-21 2017-10-16 Novo Nordisk Healthcare Ag Transglutaminase-mediated peptide conjugation
JP2007522805A (ja) * 2004-02-03 2007-08-16 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 新規化合物
US9187549B2 (en) 2004-12-23 2015-11-17 Novo Nordisk Healthcare A/G Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
WO2006134173A2 (en) 2005-06-17 2006-12-21 Novo Nordisk Health Care Ag Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
ES2397851T3 (es) 2005-07-13 2013-03-11 Novo Nordisk Health Care Ag Células de inactivación proteínica de la célula huésped para la producción de proteínas terapéuticas
CN101268185B (zh) 2005-09-01 2013-03-27 诺沃-诺迪斯克保健股份有限公司 因子ⅶ多肽的疏水作用色谱纯化
EP1926817A2 (de) * 2005-09-14 2008-06-04 Novo Nordisk Health Care AG Menschliche gerinnungsfaktor-vii-polypeptide
JP5570809B2 (ja) 2006-09-01 2014-08-13 ノボ ノルディスク ヘルス ケア アーゲー 修飾タンパク質
BRPI0720282B8 (pt) 2006-12-15 2021-05-25 Baxalta GmbH construção proteica, composição farmacêutica, e, kit
WO2008127702A2 (en) 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypetides and uses thereof
SG10201503304RA (en) 2007-12-27 2015-06-29 Baxter Int Cell culture processes
TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
MX2010011721A (es) * 2008-04-30 2010-11-30 Danisco Inc Nuevas variantes de alfa-amilasa quimericas.
EP2285829B1 (de) * 2008-05-30 2015-07-08 Novo Nordisk Health Care AG Verfahren zur steuerung einer polypeptidmodifikationsreaktion
NO2440239T3 (de) 2009-06-09 2018-02-10
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
CA2769326A1 (en) 2009-07-27 2011-02-10 Baxter International Inc. Blood coagulation protein conjugates
PL2459224T3 (pl) 2009-07-27 2017-08-31 Baxalta GmbH Koniugaty białka związanego z krzepnięciem krwi
RU2533619C2 (ru) 2009-07-27 2014-11-20 Лайпоксен Текнолоджиз Лимитед Гликополисиалирование белков, не являющихся белками свертывания крови
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
EP2561070B1 (de) 2010-04-20 2015-06-03 Octapharma AG Neuer Stabilisator für pharmazeutische Proteine
TW201212938A (en) 2010-06-30 2012-04-01 Novo Nordisk As Antibodies that are capable of specifically binding tissue factor pathway inhibitor
CA2822591C (en) 2010-12-22 2020-12-29 Baxter International Inc. Materials and methods for conjugating a water soluble fatty acid derivative to a protein
EP2680875B1 (de) 2011-03-02 2019-10-23 Novo Nordisk Health Care AG Gerinnungsfaktor-targeting auf tlt-1 auf aktivierten plättchen
AU2012267484B2 (en) 2011-06-10 2017-03-23 Bioverativ Therapeutics Inc. Pro-coagulant compounds and methods of use thereof
EP2554161A1 (de) 2011-08-02 2013-02-06 LFB Biotechnologies Pharmazeutische Zusammensetzung enthaltend Faktor VII in Mizellen verkapselt
WO2014057068A1 (en) 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide
JP2015533152A (ja) 2012-10-15 2015-11-19 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 第ｖｉｉ因子コンジュゲート
AU2014336252A1 (en) 2013-10-15 2016-04-07 Novo Nordisk Health Care Ag Coagulation factor VII polypeptides
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40861A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
DK3402537T3 (da) 2016-01-15 2021-03-29 Rigshospitalet Kvantitativ PET-afbildning af vævsfaktorekspression under anvendelse af 18-F mærket, aktiv positions-inhiberet faktor VII
EP3833381B1 (de) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modifizierte faktor-vii-polypeptide zur subkutanen verabreichung
CN113336841B (zh) * 2021-06-02 2022-09-23 中国医学科学院血液病医院(中国医学科学院血液学研究所) F8蛋白变体及利用其制备的基因治疗载体

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4456591A (en) 1981-06-25 1984-06-26 Baxter Travenol Laboratories, Inc. Therapeutic method for activating factor VII
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4975282A (en) 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
DK323587D0 (da) * 1987-06-25 1987-06-25 Novo Industri As Protein
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0279582A3 (de) 1987-02-17 1989-10-18 Pharming B.V. DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5073964A (en) 1989-08-04 1991-12-17 Aware, Inc. Signal processing device and method
US5580560A (en) * 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
EP0521873B1 (de) 1990-01-29 1999-06-02 Zymogenetics, Inc. Antikoagulierende proteine
DE69232310T2 (de) 1991-01-11 2002-08-14 American Red Cross Washington Expression von aktivem menschlichem Protein C im Milchdrüsengewebe transgener Tiere
DE69429429T2 (de) * 1993-05-21 2002-05-16 Novo Nordisk As MODIFIZIERTER FAKTOR VII zur Hemmung der vaskulären Restenosis und Thrombozytenablagerung
EP2319541A1 (de) * 2000-02-11 2011-05-11 Bayer HealthCare LLC Faktor VII- oder VIIA-ähnliche Konjugate
EP1280548B1 (de) * 2000-05-03 2013-12-11 Novo Nordisk Health Care AG Subkutane Verabreichung des Koagulationsfaktor VII
JP4455802B2 (ja) * 2000-05-03 2010-04-21 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ヒト第ｖｉｉ凝固因子変異型
BR0110659A (pt) * 2000-05-10 2003-02-11 Novo Nordisk As Composição farmacêutica, kit, uso de um fator viia em combinação com um fator, xiii, e, métodos para intensificação da formação de coágulo de fibrina em um indivìduo e para tratar de episódios de hemorragia em um indivìduo

Also Published As

Publication number Publication date
WO2002022776A2 (en) 2002-03-21
EP2226385A1 (de) 2010-09-08
PL204888B1 (pl) 2010-02-26
JP4361728B2 (ja) 2009-11-11
HUP0301246A2 (hu) 2003-08-28
JP2009278980A (ja) 2009-12-03
IL196482A (en) 2011-03-31
IL206229A (en) 2012-02-29
WO2002022776A3 (en) 2002-07-18
PL360384A1 (en) 2004-09-06
JP4814359B2 (ja) 2011-11-16
JP2004508822A (ja) 2004-03-25
EP1319067A2 (de) 2003-06-18
IL154520A (en) 2010-06-16
AU2001287550B2 (en) 2007-03-22
AU8755001A (en) 2002-03-26
WO2002022776A9 (en) 2003-05-22
HUP0301246A3 (en) 2005-12-28
EP2253703A1 (de) 2010-11-24
EP2226385B1 (de) 2013-07-10

Similar Documents

Publication Publication Date Title
IL154520A0 (en) Human coagulation factor vii variants
NO20031129L (no) Human koagulasjonsfaktor VII-varianter
EP1296699A4 (de) Therapeutische verbindungen
HUP0302360A3 (en) Medical arrangement
HUP0500060A3 (en) Human coagulation factor vii polypeptides
GB0009606D0 (en) Therapeutic combinations
GB0028429D0 (en) Therapy
GB0009591D0 (en) Medical combinations
GB0011244D0 (en) Tissue regrafting
PL362855A1 (en) Improved treatment
EG25829A (en) Novel treatment
TW543376U (en) Physiological pant
GB0030541D0 (en) Medical uses
GB0031321D0 (en) Treatment
TWI315313B (en) Human coagulation factor vii variants
TW584366U (en) Disposable wristband
AU9481201A (en) Human nedd-1
GB0019728D0 (en) Novel treatment
AU144071S (en) Tissue
AU143951S (en) Tissue
AU143950S (en) Tissue
AU143726S (en) Tissue
GB0026771D0 (en) Medical uses
GB0015251D0 (en) Medical unit
AU148103S (en) Tissue