SG10201503304RA - Cell culture processes - Google Patents

Cell culture processes

Info

Publication number
SG10201503304RA
SG10201503304RA SG10201503304RA SG10201503304RA SG10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA SG 10201503304R A SG10201503304R A SG 10201503304RA
Authority
SG
Singapore
Prior art keywords
cell culture
culture processes
processes
cell
culture
Prior art date
Application number
SG10201503304RA
Inventor
Andre Giovagnoli
Sylvain Roy
Veronique Ducros
Virginie Charlot
Yves-Olivier Stauffer
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of SG10201503304RA publication Critical patent/SG10201503304RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6437Coagulation factor VIIa (3.4.21.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6454Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489Metalloendopeptidases (3.4.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21021Coagulation factor VIIa (3.4.21.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21075Furin (3.4.21.75)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
SG10201503304RA 2007-12-27 2008-12-22 Cell culture processes SG10201503304RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US932807P 2007-12-27 2007-12-27

Publications (1)

Publication Number Publication Date
SG10201503304RA true SG10201503304RA (en) 2015-06-29

Family

ID=40350258

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012095329A SG187397A1 (en) 2007-12-27 2008-12-22 Cell culture processes
SG10201503304RA SG10201503304RA (en) 2007-12-27 2008-12-22 Cell culture processes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012095329A SG187397A1 (en) 2007-12-27 2008-12-22 Cell culture processes

Country Status (21)

Country Link
US (2) US9359629B2 (en)
EP (4) EP2574677B1 (en)
JP (3) JP5727790B2 (en)
KR (4) KR101798813B1 (en)
CN (2) CN106222220A (en)
AR (2) AR069956A1 (en)
AU (1) AU2008345231B2 (en)
BR (1) BR122019022434B8 (en)
CA (1) CA2709890A1 (en)
DK (3) DK2574676T3 (en)
ES (3) ES2649094T3 (en)
HK (1) HK1246827A1 (en)
HR (3) HRP20171375T1 (en)
HU (2) HUE036496T2 (en)
MX (2) MX343271B (en)
NZ (1) NZ586250A (en)
PL (3) PL2235197T3 (en)
PT (3) PT2235197T (en)
SG (2) SG187397A1 (en)
SI (3) SI2235197T1 (en)
WO (1) WO2009086309A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103555652A (en) 2006-09-13 2014-02-05 Abbvie公司 Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TWI610936B (en) 2008-10-20 2018-01-11 艾伯維有限公司 Isolation and purification of antibodies using protein a affinity chromatography
CA2738499A1 (en) 2008-10-20 2010-04-29 Abbott Laboratories Viral inactivation during purification of antibodies
SG178194A1 (en) 2009-07-31 2012-03-29 Baxter Int Cell culture medium for adamts protein expression
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
US8852888B2 (en) * 2010-07-08 2014-10-07 Baxter International Inc. Method of producing recombinant high molecular weight vWF in cell culture
BR112013023167A2 (en) * 2011-03-11 2016-09-06 Univ São Paulo method for producing recombinant human factor viii, recombinant human factor viii, pharmaceutical product, use of recombinant human factor viii, method for treating diseases related to decrease, inactivation or absence of factor viii, use of endoprotease spc6 and / or pace4 ai and / or pacesol and proteolytic processing of recombinant human factor viii
EP2511293A1 (en) 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
AU2013309506A1 (en) 2012-09-02 2015-03-12 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
KR20150026024A (en) * 2013-08-30 2015-03-11 한미약품 주식회사 Method for mass production of factor vii analog
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
CA2943357C (en) 2014-03-25 2023-06-27 Genentech, Inc. Methods of preparing a poloxamer for use in cell culture medium
PE20161326A1 (en) * 2014-04-10 2016-12-11 Bayer Healthcare Llc POWDER FORMULATION OF COMPOUND MEDIA AND PREPARATION METHOD OF LIQUID MEDIUM FOR CELL CULTURE
CA2951025A1 (en) * 2014-06-03 2015-12-10 Lupin Limited Cell culture process for producing a protein
EP3521440B1 (en) 2014-06-04 2022-02-09 Amgen Inc. Methods for harvesting mammalian cell cultures
EP4089109A3 (en) 2015-05-22 2023-03-01 CSL Behring Lengnau AG Methods for preparing modified von willebrand factor
EP3529350A1 (en) * 2016-10-19 2019-08-28 H. Hoffnabb-La Roche Ag Method for producing an immunoconjugate
CN114657118B (en) * 2021-12-31 2023-12-01 广州齐志生物工程设备有限公司 Multiple amplification method of 2BS cells in bioreactor

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456591A (en) * 1981-06-25 1984-06-26 Baxter Travenol Laboratories, Inc. Therapeutic method for activating factor VII
SE8501050D0 (en) 1985-03-05 1985-03-05 Kabivitrum Ab BIOLOGICALLY ACTIVE FRAGMENTS OF HUMAN ANTIHEMOPHILIC FACTOR AND METHOD FOR PREPARATION THEREOF
DE3683980D1 (en) 1985-04-12 1992-04-02 Genetics Inst NEW PROCOAGULATION PROTEINS.
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US5422260A (en) 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
IE69026B1 (en) * 1987-06-12 1996-08-07 Immuno Ag Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US5200510A (en) 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JPH0787799B2 (en) * 1988-03-30 1995-09-27 森永製菓株式会社 Monoclonal antibody production enhancement method
US6100050A (en) * 1989-08-17 2000-08-08 Dade Behring Ag Factor VIII:Ca chromogenic assay
NL9000917A (en) 1989-10-25 1991-05-16 Holland Biotechnology PHARMACEUTICAL PREPARATION WITH ENDOPROTEOLYTIC ACTIVITY; PROCESS FOR ENDOPROTEOLYTIC PROCESSING OF (PRECURSOR) PROTEINS AND FOR (MICRO) ORGANIC PREPARATION OF PROTEINS.
US5580560A (en) 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
SE465222C5 (en) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab A recombinant human factor VIII derivative and process for its preparation
AT393356B (en) * 1989-12-22 1991-10-10 Immuno Ag METHOD FOR PRODUCING TBE VIRUS ANTIGES
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
IE914102A1 (en) 1990-11-26 1992-06-03 Genetics Inst Expression of pace in host cells and methods of use thereof
US5997864A (en) 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
HU218890B (en) 1991-02-28 2000-12-28 Novo Nordisk A/S Coagulation inhibiting modified factors vii, polynukleotid molecules coding them, mammalian cells transfected with the, polynucleotide molecules, pharmaceutical preparations containing the coagulation inhibiting modified factors vii and process for ...
US5661008A (en) 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
HU220194B (en) 1992-10-02 2001-11-28 Genetics Institute Inc. Composition comprising coagulation factor viii formulation and process for its preparation
AT403167B (en) * 1994-11-14 1997-11-25 Immuno Ag SELECTION AND EXPRESSION OF FOREIGN PROTEINS BY MEANS OF A SELECTION-AMPLIFICATION SYSTEM
AU1333797A (en) * 1995-12-15 1997-07-03 Systemix, Inc. Method for obtaining retroviral vector supernatant having high transduction efficiency
AT403765B (en) 1996-04-12 1998-05-25 Immuno Ag METHOD FOR PRODUCING A PREPARATION CONTAINING A HIGHLY CLEANED COMPLEX
WO1998000521A1 (en) * 1996-06-28 1998-01-08 The Green Cross Corporation Serum-free media, method for culturing animal cells, and process for producing physiologically active substances
US5854021A (en) * 1997-02-28 1998-12-29 Bayer Corporation Enhance protein production method
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (en) 1997-06-20 2001-02-26 Immuno Ag RECOMBINANT CELL CLONE WITH INCREASED STABILITY IN SERUM- AND PROTEIN-FREE MEDIUM AND METHOD FOR OBTAINING THE STABLE CELL CLONE
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6017882A (en) 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
PT1154796E (en) 1999-02-22 2007-09-28 Baxter Int Novel albumin-free factor viii formulations
DK1194161T3 (en) * 1999-07-13 2006-02-13 Biovitrum Ab Stable factor VIII compositions
JP4451514B2 (en) 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 Blood coagulation factor VII variant
JP2001120262A (en) * 1999-10-26 2001-05-08 Welfide Corp Method for enhancing production of physiologically active substance
SE518174C2 (en) 1999-11-16 2002-09-03 Appliedsensor Sweden Ab Detection method of unwanted microbial infection in animal cell culture
JP2003521930A (en) 2000-02-11 2003-07-22 マキシゲン・エイピーエス Factor VII or Factor VIIa-like molecule
US6168941B1 (en) * 2000-04-07 2001-01-02 Genvec, Inc. Method of producing adenoviral vector stocks
EP1282693B1 (en) 2000-05-03 2010-10-20 Novo Nordisk Health Care AG Human coagulation factor vii variants
WO2002022776A2 (en) 2000-09-13 2002-03-21 Novo Nordisk A/S Human coagulation factor vii variants
US20040185535A1 (en) * 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
WO2002038162A1 (en) 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
US6926894B2 (en) * 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US20030040095A1 (en) * 2001-03-16 2003-02-27 Achille Arini Method for the production of pharmaceutically active recombinant proteins
KR20030085041A (en) 2001-03-22 2003-11-01 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Coagulation factor ⅶ derivatives
JP2003047461A (en) * 2001-07-31 2003-02-18 Astec:Kk Method for carrying out high-density cell culture of cell by using apatite sheet, culturing device and cell culture module
CA2458980C (en) * 2001-08-31 2012-10-30 Bayer Healthcare Ag A unit and a process for carrying out high cell density fermentation
HUP0500060A3 (en) 2001-09-27 2010-01-28 Novo Nordisk Healthcare Ag Human coagulation factor vii polypeptides
BR0212780A (en) * 2001-10-02 2004-10-13 Novo Nordisk Healthcare Ag Methods for producing eukaryotic cell polypeptides, for cultivating eukaryotic cells and for harvesting polypeptides produced by eukaryotic cells
ES2490590T3 (en) 2001-11-02 2014-09-04 Novo Nordisk Health Care Ag Human coagulation factor VII polypeptides
US20030119723A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and PAI-1 polypeptides
EP2287288B1 (en) * 2002-07-09 2012-11-07 Baxter International Inc. Animal protein free media for cultivation of cells
WO2004092218A1 (en) * 2003-04-17 2004-10-28 Mitsubishi Pharma Corporation Process for producing recombinant antithrombin
DK1720972T3 (en) * 2004-03-05 2014-04-14 Dsm Ip Assets Bv METHOD OF CELL CULTIVATION USING CONTINUOUS PERFUSION AND ALTERNATIVE TANGENTIAL FLOW
US8530192B2 (en) * 2005-02-11 2013-09-10 Novo Nordisk Healthcare Ag Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate
CN101360820A (en) * 2006-01-04 2009-02-04 巴克斯特国际公司 Oligopeptide-free cell culture media
ES2416079T3 (en) 2007-05-22 2013-07-30 Baxter International Inc. Preparatory purification process of human furin

Also Published As

Publication number Publication date
US20160244506A1 (en) 2016-08-25
CA2709890A1 (en) 2009-07-09
ES2647294T3 (en) 2017-12-20
AU2008345231A1 (en) 2009-07-09
BR122019022434B8 (en) 2021-07-27
JP5890854B2 (en) 2016-03-22
BRPI0821481A2 (en) 2014-11-04
AR069956A1 (en) 2010-03-03
AR110864A2 (en) 2019-05-08
KR20100097752A (en) 2010-09-03
EP2574676A1 (en) 2013-04-03
WO2009086309A2 (en) 2009-07-09
HRP20171374T1 (en) 2017-12-29
EP2235197B1 (en) 2017-07-26
SG187397A1 (en) 2013-02-28
EP2574676B1 (en) 2017-08-30
SI2235197T1 (en) 2017-10-30
AU2008345231B2 (en) 2014-09-11
JP5727790B2 (en) 2015-06-03
DK2235197T3 (en) 2017-10-09
KR101659458B1 (en) 2016-09-23
MX343271B (en) 2016-10-31
DK2574676T3 (en) 2017-10-09
EP2574677A1 (en) 2013-04-03
HRP20171495T1 (en) 2018-01-26
SI2574677T1 (en) 2017-11-30
CN101910408A (en) 2010-12-08
US9359629B2 (en) 2016-06-07
ES2649094T3 (en) 2018-01-10
KR20160112025A (en) 2016-09-27
HUE036496T2 (en) 2018-07-30
HK1246827A1 (en) 2018-09-14
HUE036712T2 (en) 2018-07-30
JP2011507551A (en) 2011-03-10
DK2574677T3 (en) 2017-11-06
PL2574677T3 (en) 2017-12-29
MX343269B (en) 2016-10-31
PL2574676T3 (en) 2017-12-29
SI2574676T1 (en) 2017-10-30
ES2644089T3 (en) 2017-11-27
US20090176269A1 (en) 2009-07-09
KR101798813B1 (en) 2017-11-16
EP3255152A1 (en) 2017-12-13
KR20180005287A (en) 2018-01-15
EP2574677B1 (en) 2017-09-13
HRP20171375T1 (en) 2017-12-15
PT2574676T (en) 2017-10-11
WO2009086309A3 (en) 2009-10-01
NZ586250A (en) 2012-11-30
PT2574677T (en) 2017-10-19
CN106222220A (en) 2016-12-14
JP2014100148A (en) 2014-06-05
BR122019022434B1 (en) 2020-11-03
PL2235197T3 (en) 2018-01-31
PT2235197T (en) 2017-10-11
KR20170126514A (en) 2017-11-17
KR101818411B1 (en) 2018-01-12
JP2016013140A (en) 2016-01-28
EP2235197A2 (en) 2010-10-06

Similar Documents

Publication Publication Date Title
HK1246827A1 (en) Cell culture processes
SG10201510384UA (en) Cell culture improvements
HK1216883A1 (en) Stem cell cultures
GB0720484D0 (en) Cells
GB0605450D0 (en) Cell co-culture
EP1997877A4 (en) Cell culture substrate
EP2028264A4 (en) Cell incubator
EP2128242A4 (en) Cell culture module
GB0517382D0 (en) Cell culture
GB0800524D0 (en) Cell culture system
GB0817990D0 (en) Cell culture vessel
IL194524A0 (en) Three dimensional cell culture
EP2271739A4 (en) Product for cell culture
GB0606671D0 (en) Cell Culture
GB0817240D0 (en) Modified bacterial cell
GB0808778D0 (en) Cell culture technique
GB0718014D0 (en) Cell culture apparatus
GB0922428D0 (en) Cell culture
GB0915268D0 (en) Cell culture
GB0700936D0 (en) Cells
GB0810505D0 (en) M cell
GB0806524D0 (en) Cell differentiation
GB0724655D0 (en) Recipient for cell cultivation
GB0806637D0 (en) Culture
GB0806639D0 (en) Culture