FI116292B - Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita - Google Patents
Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita Download PDFInfo
- Publication number
- FI116292B FI116292B FI20030026A FI20030026A FI116292B FI 116292 B FI116292 B FI 116292B FI 20030026 A FI20030026 A FI 20030026A FI 20030026 A FI20030026 A FI 20030026A FI 116292 B FI116292 B FI 116292B
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- FI
- Finland
- Prior art keywords
- formula
- compound
- halo
- iii
- ethyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20030026A FI116292B (fi) | 2003-01-08 | 2003-01-08 | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
MXPA05007217A MXPA05007217A (es) | 2003-01-08 | 2004-01-08 | Proceso para la preparacion de derivados de imidazol sustituidos y los productos intermedios usados en este proceso. |
PL378179A PL213564B1 (pl) | 2003-01-08 | 2004-01-08 | Sposób wytwarzania podstawionych pochodnych imidazolu i zwiazki posrednie stosowane w sposobie |
AU2004203941A AU2004203941B2 (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
AT04700707T ATE425972T1 (de) | 2003-01-08 | 2004-01-08 | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte |
DE602004020050T DE602004020050D1 (de) | 2003-01-08 | 2004-01-08 | Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte |
RU2005125044/04A RU2329253C2 (ru) | 2003-01-08 | 2004-01-08 | Способ получения производных замещенного имидазола и промежуточные соединения, используемые в этом способе |
KR1020057012682A KR101079065B1 (ko) | 2003-01-08 | 2004-01-08 | 치환된 이미다졸 유도체를 제조하기 위한 방법 및 공정에서사용된 중간체 |
BR0406676-6A BRPI0406676A (pt) | 2003-01-08 | 2004-01-08 | Processo para preparar derivados de imidazol substituìdo, para preparar um composto e composto resultante |
JP2006500148A JP4592680B2 (ja) | 2003-01-08 | 2004-01-08 | 置換イミダゾール誘導体の製造方法およびその製造方法で使用される中間体 |
PT04700707T PT1581504E (pt) | 2003-01-08 | 2004-01-08 | Processo de preparação de derivados de imidazole substituídos e intermediários utilizados no processo |
NZ539831A NZ539831A (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
CA2511969A CA2511969C (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
CNB2004800019799A CN100339368C (zh) | 2003-01-08 | 2004-01-08 | 取代的咪唑衍生物的制备方法及该方法中使用的中间体 |
PCT/FI2004/000004 WO2004063168A1 (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
US10/537,177 US7223871B2 (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
EP04700707A EP1581504B1 (en) | 2003-01-08 | 2004-01-08 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
ES04700707T ES2322463T3 (es) | 2003-01-08 | 2004-01-08 | Preocedimiento para preparar derivados de imidazol sustituidos y productos intermedios utilizados en el procedimiento. |
DK04700707T DK1581504T3 (da) | 2003-01-08 | 2004-01-08 | Fremgangsmåde til fremstilling af subsituterede imidazolderivater og intermediater anvendt i fremgangsmåden |
IL168452A IL168452A (en) | 2003-01-08 | 2005-05-05 | Process for preparing substituted imidazole derivatives and intermediates used in the process |
NO20053712A NO330965B1 (no) | 2003-01-08 | 2005-08-01 | Fremgangsmate for fremstilling av substituerte imidazolderivater, mellomprodukter anvendt i fremgangsmaten samt fremgangsmate for fremstilling av mellomprodukt |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20030026 | 2003-01-08 | ||
FI20030026A FI116292B (fi) | 2003-01-08 | 2003-01-08 | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
Publications (3)
Publication Number | Publication Date |
---|---|
FI20030026A0 FI20030026A0 (fi) | 2003-01-08 |
FI20030026A FI20030026A (fi) | 2004-07-09 |
FI116292B true FI116292B (fi) | 2005-10-31 |
Family
ID=8565279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20030026A FI116292B (fi) | 2003-01-08 | 2003-01-08 | Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita |
Country Status (21)
Country | Link |
---|---|
US (1) | US7223871B2 (zh) |
EP (1) | EP1581504B1 (zh) |
JP (1) | JP4592680B2 (zh) |
KR (1) | KR101079065B1 (zh) |
CN (1) | CN100339368C (zh) |
AT (1) | ATE425972T1 (zh) |
AU (1) | AU2004203941B2 (zh) |
BR (1) | BRPI0406676A (zh) |
CA (1) | CA2511969C (zh) |
DE (1) | DE602004020050D1 (zh) |
DK (1) | DK1581504T3 (zh) |
ES (1) | ES2322463T3 (zh) |
FI (1) | FI116292B (zh) |
IL (1) | IL168452A (zh) |
MX (1) | MXPA05007217A (zh) |
NO (1) | NO330965B1 (zh) |
NZ (1) | NZ539831A (zh) |
PL (1) | PL213564B1 (zh) |
PT (1) | PT1581504E (zh) |
RU (1) | RU2329253C2 (zh) |
WO (1) | WO2004063168A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
CN102548951A (zh) * | 2009-07-24 | 2012-07-04 | 帝斯曼医药化学雷根斯堡技术有限公司 | 作为中间体的二氢化茚衍生物 |
JP2013500983A (ja) * | 2009-07-31 | 2013-01-10 | ドクター・レディーズ・ラボラトリーズ・リミテッド | フィパメゾールの調製 |
EP2502917A1 (en) * | 2011-03-17 | 2012-09-26 | Santhera Pharmaceuticals (Schweiz) AG | Solid state crystalline forms of 4-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI833794A0 (fi) * | 1983-10-18 | 1983-10-18 | Farmos Oy | Substituerade 2-merkapto-imidazoler |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
CA2382861A1 (en) | 1999-09-06 | 2001-03-15 | Sung-Kee Kim | Process for preparing a 1-substituted 5-hydroxymethyl imidazole |
US7091232B2 (en) * | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
-
2003
- 2003-01-08 FI FI20030026A patent/FI116292B/fi not_active IP Right Cessation
-
2004
- 2004-01-08 NZ NZ539831A patent/NZ539831A/en not_active IP Right Cessation
- 2004-01-08 BR BR0406676-6A patent/BRPI0406676A/pt not_active IP Right Cessation
- 2004-01-08 MX MXPA05007217A patent/MXPA05007217A/es active IP Right Grant
- 2004-01-08 CN CNB2004800019799A patent/CN100339368C/zh not_active Expired - Fee Related
- 2004-01-08 AT AT04700707T patent/ATE425972T1/de active
- 2004-01-08 CA CA2511969A patent/CA2511969C/en not_active Expired - Fee Related
- 2004-01-08 JP JP2006500148A patent/JP4592680B2/ja not_active Expired - Fee Related
- 2004-01-08 ES ES04700707T patent/ES2322463T3/es not_active Expired - Lifetime
- 2004-01-08 DK DK04700707T patent/DK1581504T3/da active
- 2004-01-08 WO PCT/FI2004/000004 patent/WO2004063168A1/en active Application Filing
- 2004-01-08 US US10/537,177 patent/US7223871B2/en not_active Expired - Fee Related
- 2004-01-08 AU AU2004203941A patent/AU2004203941B2/en not_active Ceased
- 2004-01-08 PT PT04700707T patent/PT1581504E/pt unknown
- 2004-01-08 EP EP04700707A patent/EP1581504B1/en not_active Expired - Lifetime
- 2004-01-08 KR KR1020057012682A patent/KR101079065B1/ko not_active IP Right Cessation
- 2004-01-08 PL PL378179A patent/PL213564B1/pl not_active IP Right Cessation
- 2004-01-08 DE DE602004020050T patent/DE602004020050D1/de not_active Expired - Lifetime
- 2004-01-08 RU RU2005125044/04A patent/RU2329253C2/ru not_active IP Right Cessation
-
2005
- 2005-05-05 IL IL168452A patent/IL168452A/en not_active IP Right Cessation
- 2005-08-01 NO NO20053712A patent/NO330965B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE425972T1 (de) | 2009-04-15 |
IL168452A (en) | 2009-07-20 |
CN1723202A (zh) | 2006-01-18 |
KR20050091065A (ko) | 2005-09-14 |
US7223871B2 (en) | 2007-05-29 |
NO20053712L (no) | 2005-08-01 |
WO2004063168A1 (en) | 2004-07-29 |
MXPA05007217A (es) | 2005-09-12 |
DK1581504T3 (da) | 2009-06-29 |
RU2005125044A (ru) | 2006-01-20 |
DE602004020050D1 (de) | 2009-04-30 |
AU2004203941A1 (en) | 2004-07-29 |
AU2004203941B2 (en) | 2009-08-06 |
CA2511969A1 (en) | 2004-07-29 |
FI20030026A (fi) | 2004-07-09 |
PL378179A1 (pl) | 2006-03-06 |
NZ539831A (en) | 2007-11-30 |
ES2322463T3 (es) | 2009-06-22 |
PT1581504E (pt) | 2009-05-26 |
KR101079065B1 (ko) | 2011-11-02 |
RU2329253C2 (ru) | 2008-07-20 |
JP4592680B2 (ja) | 2010-12-01 |
EP1581504B1 (en) | 2009-03-18 |
US20060025465A1 (en) | 2006-02-02 |
CN100339368C (zh) | 2007-09-26 |
CA2511969C (en) | 2011-10-11 |
FI20030026A0 (fi) | 2003-01-08 |
EP1581504A1 (en) | 2005-10-05 |
BRPI0406676A (pt) | 2005-12-20 |
JP2006515349A (ja) | 2006-05-25 |
PL213564B1 (pl) | 2013-03-29 |
NO330965B1 (no) | 2011-08-29 |
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