FI115034B - Menetelmä uudelleenkiteytymättömän estradiolia sisältävän laastarin valmistamiseksi - Google Patents
Menetelmä uudelleenkiteytymättömän estradiolia sisältävän laastarin valmistamiseksi Download PDFInfo
- Publication number
- FI115034B FI115034B FI955259A FI955259A FI115034B FI 115034 B FI115034 B FI 115034B FI 955259 A FI955259 A FI 955259A FI 955259 A FI955259 A FI 955259A FI 115034 B FI115034 B FI 115034B
- Authority
- FI
- Finland
- Prior art keywords
- estradiol
- weight
- esters
- added
- layer
- Prior art date
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims abstract description 43
- 229930182833 estradiol Natural products 0.000 title claims abstract description 39
- 229960005309 estradiol Drugs 0.000 title claims abstract description 39
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000010410 layer Substances 0.000 claims abstract description 32
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 24
- 239000000583 progesterone congener Substances 0.000 claims abstract description 19
- 239000013543 active substance Substances 0.000 claims abstract description 17
- 239000011241 protective layer Substances 0.000 claims abstract description 6
- 238000013270 controlled release Methods 0.000 claims abstract description 5
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- 150000002148 esters Chemical class 0.000 claims description 19
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 18
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- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 18
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- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 13
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4314970 | 1993-05-06 | ||
| DE4314970 | 1993-05-06 | ||
| DE4336557 | 1993-10-27 | ||
| DE4336557A DE4336557C2 (de) | 1993-05-06 | 1993-10-27 | Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
| EP9401279 | 1994-04-25 | ||
| PCT/EP1994/001279 WO1994026257A1 (de) | 1993-05-06 | 1994-04-25 | Estradiolhaltiges transdermales therapeutisches system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955259A0 FI955259A0 (fi) | 1995-11-02 |
| FI955259L FI955259L (fi) | 1995-11-30 |
| FI115034B true FI115034B (fi) | 2005-02-28 |
Family
ID=25925640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955259A FI115034B (fi) | 1993-05-06 | 1995-11-02 | Menetelmä uudelleenkiteytymättömän estradiolia sisältävän laastarin valmistamiseksi |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6143319A (cs) |
| EP (1) | EP0697860B1 (cs) |
| JP (1) | JP3885233B2 (cs) |
| KR (1) | KR100343877B1 (cs) |
| CN (1) | CN1136843C (cs) |
| AT (1) | ATE196843T1 (cs) |
| AU (1) | AU696816B2 (cs) |
| CA (1) | CA2160775C (cs) |
| CZ (1) | CZ291656B6 (cs) |
| DE (2) | DE4336557C2 (cs) |
| DK (1) | DK0697860T3 (cs) |
| ES (1) | ES2152979T3 (cs) |
| FI (1) | FI115034B (cs) |
| GR (1) | GR3035200T3 (cs) |
| HU (1) | HU221166B1 (cs) |
| IL (1) | IL109508A (cs) |
| MX (1) | MXPA94003365A (cs) |
| MY (1) | MY111515A (cs) |
| NO (1) | NO309891B1 (cs) |
| NZ (1) | NZ266140A (cs) |
| PL (1) | PL179962B1 (cs) |
| PT (1) | PT697860E (cs) |
| RU (1) | RU2140784C1 (cs) |
| SI (1) | SI0697860T1 (cs) |
| SK (1) | SK282230B6 (cs) |
| TW (1) | TW382599B (cs) |
| UA (1) | UA29476C2 (cs) |
| WO (1) | WO1994026257A1 (cs) |
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-
1993
- 1993-10-27 DE DE4336557A patent/DE4336557C2/de not_active Expired - Lifetime
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1994
- 1994-04-22 MY MYPI94000991A patent/MY111515A/en unknown
- 1994-04-25 JP JP52486094A patent/JP3885233B2/ja not_active Expired - Lifetime
- 1994-04-25 DK DK94915533T patent/DK0697860T3/da active
- 1994-04-25 HU HU9503168A patent/HU221166B1/hu unknown
- 1994-04-25 PL PL94311590A patent/PL179962B1/pl unknown
- 1994-04-25 ES ES94915533T patent/ES2152979T3/es not_active Expired - Lifetime
- 1994-04-25 SI SI9430354T patent/SI0697860T1/xx unknown
- 1994-04-25 EP EP94915533A patent/EP0697860B1/de not_active Expired - Lifetime
- 1994-04-25 AT AT94915533T patent/ATE196843T1/de active
- 1994-04-25 NZ NZ266140A patent/NZ266140A/en not_active IP Right Cessation
- 1994-04-25 DE DE59409548T patent/DE59409548D1/de not_active Expired - Lifetime
- 1994-04-25 CA CA002160775A patent/CA2160775C/en not_active Expired - Lifetime
- 1994-04-25 KR KR1019950705046A patent/KR100343877B1/ko not_active Expired - Lifetime
- 1994-04-25 UA UA95114785A patent/UA29476C2/uk unknown
- 1994-04-25 SK SK1379-95A patent/SK282230B6/sk not_active IP Right Cessation
- 1994-04-25 CZ CZ19952892A patent/CZ291656B6/cs not_active IP Right Cessation
- 1994-04-25 PT PT94915533T patent/PT697860E/pt unknown
- 1994-04-25 WO PCT/EP1994/001279 patent/WO1994026257A1/de active IP Right Grant
- 1994-04-25 RU RU95122633A patent/RU2140784C1/ru active
- 1994-04-25 AU AU67213/94A patent/AU696816B2/en not_active Expired
- 1994-04-25 CN CNB941920070A patent/CN1136843C/zh not_active Expired - Lifetime
- 1994-05-02 IL IL10950894A patent/IL109508A/en not_active IP Right Cessation
- 1994-05-06 MX MXPA94003365A patent/MXPA94003365A/es active IP Right Grant
- 1994-06-17 TW TW083105530A patent/TW382599B/zh not_active IP Right Cessation
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1995
- 1995-11-02 FI FI955259A patent/FI115034B/fi not_active IP Right Cessation
- 1995-11-03 NO NO954413A patent/NO309891B1/no not_active IP Right Cessation
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1997
- 1997-10-30 US US08/961,039 patent/US6143319A/en not_active Expired - Lifetime
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2000
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2001
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