NO309891B1 - Transdermalt terapeutisk system og fremgangsmÕte for fremstilling derav - Google Patents
Transdermalt terapeutisk system og fremgangsmÕte for fremstilling derav Download PDFInfo
- Publication number
- NO309891B1 NO309891B1 NO954413A NO954413A NO309891B1 NO 309891 B1 NO309891 B1 NO 309891B1 NO 954413 A NO954413 A NO 954413A NO 954413 A NO954413 A NO 954413A NO 309891 B1 NO309891 B1 NO 309891B1
- Authority
- NO
- Norway
- Prior art keywords
- transdermal therapeutic
- therapeutic system
- estradiol
- weight
- layer
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title description 7
- 238000000034 method Methods 0.000 title description 5
- 239000013543 active substance Substances 0.000 claims abstract description 45
- 239000010410 layer Substances 0.000 claims abstract description 38
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract description 37
- 229960005309 estradiol Drugs 0.000 claims abstract description 34
- 229930182833 estradiol Natural products 0.000 claims abstract description 33
- 239000000583 progesterone congener Substances 0.000 claims abstract description 14
- 239000011241 protective layer Substances 0.000 claims abstract description 7
- 238000013270 controlled release Methods 0.000 claims abstract description 5
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 23
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 23
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 23
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- 229960004400 levonorgestrel Drugs 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 11
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 claims description 11
- 229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
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- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 3
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- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
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- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4314970 | 1993-05-06 | ||
| DE4336557A DE4336557C2 (de) | 1993-05-06 | 1993-10-27 | Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
| PCT/EP1994/001279 WO1994026257A1 (de) | 1993-05-06 | 1994-04-25 | Estradiolhaltiges transdermales therapeutisches system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO954413L NO954413L (no) | 1995-11-03 |
| NO954413D0 NO954413D0 (no) | 1995-11-03 |
| NO309891B1 true NO309891B1 (no) | 2001-04-17 |
Family
ID=25925640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO954413A NO309891B1 (no) | 1993-05-06 | 1995-11-03 | Transdermalt terapeutisk system og fremgangsmÕte for fremstilling derav |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6143319A (cs) |
| EP (1) | EP0697860B1 (cs) |
| JP (1) | JP3885233B2 (cs) |
| KR (1) | KR100343877B1 (cs) |
| CN (1) | CN1136843C (cs) |
| AT (1) | ATE196843T1 (cs) |
| AU (1) | AU696816B2 (cs) |
| CA (1) | CA2160775C (cs) |
| CZ (1) | CZ291656B6 (cs) |
| DE (2) | DE4336557C2 (cs) |
| DK (1) | DK0697860T3 (cs) |
| ES (1) | ES2152979T3 (cs) |
| FI (1) | FI115034B (cs) |
| GR (1) | GR3035200T3 (cs) |
| HU (1) | HU221166B1 (cs) |
| IL (1) | IL109508A (cs) |
| MX (1) | MXPA94003365A (cs) |
| MY (1) | MY111515A (cs) |
| NO (1) | NO309891B1 (cs) |
| NZ (1) | NZ266140A (cs) |
| PL (1) | PL179962B1 (cs) |
| PT (1) | PT697860E (cs) |
| RU (1) | RU2140784C1 (cs) |
| SI (1) | SI0697860T1 (cs) |
| SK (1) | SK282230B6 (cs) |
| TW (1) | TW382599B (cs) |
| UA (1) | UA29476C2 (cs) |
| WO (1) | WO1994026257A1 (cs) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR1002079B (en) * | 1994-07-26 | 1995-12-05 | Lavipharm A E | System of a special structure and composition for the rapid transdermal administration of oestrogens. |
| FR2728463A1 (fr) * | 1994-12-21 | 1996-06-28 | Lhd Lab Hygiene Dietetique | Systeme transdermique d'administration simultanee de plusieurs principes actifs |
| DE19500662C2 (de) * | 1995-01-12 | 2001-04-26 | Lohmann Therapie Syst Lts | Estradiolhaltiges Pflaster und seine Verwendung |
| AU719171B2 (en) * | 1995-01-14 | 2000-05-04 | Abbott Laboratories | A transdermal therapeutic system for the administration of (s)-3-methyl-5-(1-methyl-2-pyrrolidinyl)-isoxazole or one of its pharmaceutically acceptable salts |
| DE19501022C1 (de) * | 1995-01-14 | 1996-06-05 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Verabreichung von (s)-3-Methyl-5-(1-methyl-2-pyrrolidenyl)-isoxazol oder einem seiner pharmazeutisch akzeptablen Salze und Verfahren zu seiner Herstellung |
| DE19713141A1 (de) * | 1996-03-29 | 1997-10-30 | Labtec Gmbh | Transdermales System mit Melatonin |
| SE9602226D0 (sv) * | 1996-06-05 | 1996-06-05 | Astra Ab | Biocompatible glue |
| DE19828273B4 (de) | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
| DE19830651A1 (de) * | 1998-07-09 | 2000-01-13 | Lohmann Therapie Syst Lts | Steroidhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung |
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1993
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1994
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- 1994-04-25 DE DE59409548T patent/DE59409548D1/de not_active Expired - Lifetime
- 1994-04-25 SI SI9430354T patent/SI0697860T1/xx unknown
- 1994-04-25 KR KR1019950705046A patent/KR100343877B1/ko not_active Expired - Lifetime
- 1994-04-25 WO PCT/EP1994/001279 patent/WO1994026257A1/de active IP Right Grant
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- 1994-04-25 CZ CZ19952892A patent/CZ291656B6/cs not_active IP Right Cessation
- 1994-04-25 PL PL94311590A patent/PL179962B1/pl unknown
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- 1994-04-25 NZ NZ266140A patent/NZ266140A/en not_active IP Right Cessation
- 1994-04-25 EP EP94915533A patent/EP0697860B1/de not_active Expired - Lifetime
- 1994-04-25 DK DK94915533T patent/DK0697860T3/da active
- 1994-04-25 AT AT94915533T patent/ATE196843T1/de active
- 1994-04-25 UA UA95114785A patent/UA29476C2/uk unknown
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- 1995-11-03 NO NO954413A patent/NO309891B1/no not_active IP Right Cessation
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