FI114283B - Förfarande för stabilisering av aerosollösningspreparat - Google Patents
Förfarande för stabilisering av aerosollösningspreparat Download PDFInfo
- Publication number
- FI114283B FI114283B FI952842A FI952842A FI114283B FI 114283 B FI114283 B FI 114283B FI 952842 A FI952842 A FI 952842A FI 952842 A FI952842 A FI 952842A FI 114283 B FI114283 B FI 114283B
- Authority
- FI
- Finland
- Prior art keywords
- acid
- hfc
- aerosol
- process according
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (10)
1. Förfarande för stabilisering av ett aerosollösningspreparat, som innehälfer ett läkeämne valt ur gruppen ipratropiumbromid, oxitropiumbromid, albuterol, tiotropi- 5 umbromid och fenoterol, en HFC-propellant och ett organiskt hjälplösningsmedel, vilket läkeämne kemiskt spjälks eller sönderfaller tili följd av interaktion med hjälp-lösningsmedlet eller vatten eller nlgon annan mekanism, kännetecknat därav, att denna kemiska spjälkning reduceras tili godtagbar nivä genom att tillsätta oorganisk eller organisk syra tili aerosollösningspreparatet, vilken oorganiska eller organiska 10 syra tillsätts i en mängd, som är tillräcklig för att reducera den kemiska spjälkningen tili godtagbar nivä.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att HFC-propellanten är 1,1,1,2-tetrafluoretan. 15
3. Förfarande enligt patentkravet 1, kännetecknat därav, att HFC-propellanten är 1,1,1,2,3,3,3-heptafluorpropan.
4. Förfarande enligt patentkravet 2 eller 3, kännetecknat därav, att det organiska 20 hjälplösningsmedlet är etylalkohol. • I I · I t
· • ;· 5. Förfarande enligt patentkravet 4, kännetecknat därav, att etylalkohol förefinns i : V: intervallet ca 1,0 - 50,0 vikt-% av preparatets vikt. * I » » ♦ • ;25
6. Förfarande enligt patentkravet 4, kännetecknat därav, att den oorganiska syran :' är vald ur en grupp, vilken inbegriper svavelsyra, saltsyra, salpetersyra och fosforsy- ra.
:"7. Förfarande enligt patentkravet 4, kännetecknat därav, att den organiska syran y 30 är vald ur en grupp, vilken inbegriper askorbinsyra och citronsyra. * » · y
8. Förfarande enligt patentkravet 4, kännetecknat därav, att aerosollösningspre- : ‘ ’ paratet innehäller vatten tili en mängd av högst ca 5,0 vikt-%/vikt. 114282
9. Förfarande enligt patentkravet 6, kännetecknat därav, att den oorganiska syran förefinns i intervallet ca 0,00002-0,01 normaler.
10. Förfarande enligt patentkravet 7, kännetecknat därav, att den organiska syran 5 är askorbinsyra och förefinns i intervallet ca 0,0045-5,0 mg/ml eller att den är ci- tronsyra och förefinns i intervallet ca 0,0039-27,7 mg/ml. » I » * * I ‘ f * • * » ' I
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98785292A | 1992-12-09 | 1992-12-09 | |
US98785292 | 1992-12-09 | ||
US15354993A | 1993-11-22 | 1993-11-22 | |
US15354993 | 1993-11-22 | ||
US9311801 | 1993-12-06 | ||
PCT/US1993/011801 WO1994013262A1 (en) | 1992-12-09 | 1993-12-06 | Stabilized medicinal aerosol solution formulations |
Publications (3)
Publication Number | Publication Date |
---|---|
FI952842A0 FI952842A0 (sv) | 1995-06-09 |
FI952842A FI952842A (sv) | 1995-06-09 |
FI114283B true FI114283B (sv) | 2004-09-30 |
Family
ID=26850651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI952842A FI114283B (sv) | 1992-12-09 | 1995-06-09 | Förfarande för stabilisering av aerosollösningspreparat |
Country Status (28)
Country | Link |
---|---|
US (3) | US5676930A (sv) |
EP (1) | EP0673240B1 (sv) |
JP (1) | JP3009924B2 (sv) |
KR (1) | KR100312357B1 (sv) |
AT (1) | ATE177941T1 (sv) |
AU (2) | AU6048694A (sv) |
BG (1) | BG62382B1 (sv) |
BR (1) | BR9307627A (sv) |
CA (1) | CA2151383C (sv) |
CZ (1) | CZ284203B6 (sv) |
DE (1) | DE69324161T2 (sv) |
DK (1) | DK0673240T3 (sv) |
ES (1) | ES2129117T3 (sv) |
FI (1) | FI114283B (sv) |
GB (1) | GB2288978B (sv) |
GR (1) | GR3030529T3 (sv) |
HK (1) | HK1011620A1 (sv) |
HU (1) | HU221163B1 (sv) |
LV (1) | LV10911B (sv) |
NO (1) | NO311487B1 (sv) |
NZ (1) | NZ259192A (sv) |
PL (1) | PL177078B1 (sv) |
RO (1) | RO117414B1 (sv) |
RU (1) | RU2126248C1 (sv) |
SG (1) | SG52459A1 (sv) |
SK (1) | SK280911B6 (sv) |
UA (1) | UA27143C2 (sv) |
WO (2) | WO1994013262A1 (sv) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994013262A1 (en) * | 1992-12-09 | 1994-06-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stabilized medicinal aerosol solution formulations |
AU4655596A (en) * | 1995-01-17 | 1996-08-07 | Omega Pharmaceutical, Incorporated | Liquid stable vitamin c compositions and delivery systems, and methods of making and uses thereof |
US5653961A (en) * | 1995-03-31 | 1997-08-05 | Minnesota Mining And Manufacturing Company | Butixocort aerosol formulations in hydrofluorocarbon propellant |
TR199701167T1 (xx) * | 1995-04-14 | 1998-03-21 | Glaxo Wellcome Inc. | Albuterol i�in �l��lm�� doz inhaleri. |
KR100392280B1 (ko) * | 1995-06-27 | 2003-11-19 | 베링거 인겔하임 카게 | 추진제비함유흡입성에어로졸을제조하기위한안정한추진제비함유약제학적용액 |
DE19528145A1 (de) * | 1995-08-01 | 1997-02-06 | Boehringer Ingelheim Kg | Neue Arzneimittel und ihre Verwendung |
US6054488A (en) * | 1996-06-11 | 2000-04-25 | 3M Innovative Properties Company | Medicinal aerosol formulations of formoterol |
GB9616237D0 (en) | 1996-08-01 | 1996-09-11 | Norton Healthcare Ltd | Aerosol formulations |
DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
US20030215396A1 (en) | 1999-09-15 | 2003-11-20 | Boehringer Ingelheim Pharma Kg | Method for the production of propellant gas-free aerosols from aqueous medicament preparations |
CA2628857C (en) | 1996-12-30 | 2011-09-13 | Batelle Memorial Institute | Formulation and method for treating neoplasms by inhalation |
CZ296966B6 (cs) * | 1997-02-24 | 2006-08-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Farmaceutický prostredek |
US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
GB2326334A (en) * | 1997-06-13 | 1998-12-23 | Chiesi Farma Spa | Pharmaceutical aerosol compositions |
AU3065999A (en) * | 1998-03-10 | 1999-09-27 | Children's Hospital Of Philadelphia, The | Compositions and methods for treatment of asthma |
NZ509418A (en) * | 1998-06-18 | 2003-06-30 | Boehringer Ingelheim Pharma | Pharmaceutical formulations for aerosols with two or more active substances |
DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
DZ2947A1 (fr) | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
US20100197719A1 (en) * | 1999-05-12 | 2010-08-05 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
DE60031504T2 (de) | 1999-09-11 | 2007-04-05 | Glaxo Group Ltd., Greenford | Fluticasonpropionat arzneizubereitung |
ES2238334T3 (es) * | 1999-12-24 | 2005-09-01 | Glaxo Group Limited | Formulacion farmaceutica en aerosol de salmeterol y propionato de fluticasona. |
IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
SK286694B6 (sk) * | 2000-05-22 | 2009-03-05 | Chiesi Farmaceutici S.P.A. | Aerosólový farmaceutický prostriedok |
MEP40008A (en) * | 2000-10-12 | 2011-02-10 | Boehringer Ingelheim Pharma | Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament |
US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
DE10063957A1 (de) * | 2000-12-20 | 2002-06-27 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Dopamin-Agonisten |
US6620438B2 (en) * | 2001-03-08 | 2003-09-16 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists |
US20020085978A1 (en) * | 2000-11-10 | 2002-07-04 | Mina Buenafe | Degradation-resistant glucocorticosteroid formulations |
US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
EP1241113A1 (en) | 2001-03-12 | 2002-09-18 | CHIESI FARMACEUTICI S.p.A. | Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein |
DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
US6455028B1 (en) | 2001-04-23 | 2002-09-24 | Pharmascience | Ipratropium formulation for pulmonary inhalation |
AU2002303425A1 (en) * | 2001-04-24 | 2002-11-05 | Epigenesis Pharmaceuticals, Inc. | Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent |
ES2222294T3 (es) | 2001-07-02 | 2005-02-01 | Chiesi Farmaceutici S.P.A. | Formulacion optimizada de tobramicina para administracion en forma de aerosol. |
DE10135355C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
EP1661570A3 (en) * | 2001-09-18 | 2012-10-24 | Nycomed Danmark ApS | Compositions comprising ipatropium and xylometazoline for treatment of the common cold |
US20030191151A1 (en) * | 2001-10-26 | 2003-10-09 | Imtiaz Chaudry | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
WO2003037317A1 (en) * | 2001-10-26 | 2003-05-08 | Dey, L.P. | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma |
US8084461B2 (en) | 2001-10-26 | 2011-12-27 | Dey, L.P. | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
JP2003221335A (ja) | 2001-10-26 | 2003-08-05 | Dey Lp | 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法 |
AU3297402A (en) * | 2001-10-26 | 2003-10-30 | Dey, L.P. | An albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
US6702997B2 (en) | 2001-10-26 | 2004-03-09 | Dey, L.P. | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma |
US20030140920A1 (en) * | 2001-10-26 | 2003-07-31 | Dey L.P. | Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma |
US20030203930A1 (en) * | 2001-10-26 | 2003-10-30 | Imtiaz Chaudry | Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease |
DE10161368A1 (de) * | 2001-12-14 | 2003-07-10 | Messer Griesheim Gmbh | Vorrichtung und Verfahren zum kryogenen Abfüllen von Aerosol-Produktansätzen |
AU2002361850A1 (en) * | 2001-12-21 | 2003-07-30 | 3M Innovative Properties Company | Medicinal aerosol formulations comprising ion pair complexes |
CA2470520A1 (en) | 2001-12-21 | 2003-07-24 | 3M Innovative Properties Company | Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient |
ATE406152T1 (de) | 2001-12-21 | 2008-09-15 | 3M Innovative Properties Co | Medizinische aerosolzusammensetzungen mit einer eine amid- und/oder estergruppe enthaltenden exzipientenverbindung |
PT3536344T (pt) * | 2002-03-01 | 2020-03-26 | Chiesi Farm Spa | Formulação superfina de formoterol |
US20040126325A1 (en) * | 2002-03-12 | 2004-07-01 | David Lewis | Medicinal aerosol solution formulation products with improved chemical stability |
US7311894B2 (en) * | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
AU2003233583A1 (en) * | 2002-05-24 | 2003-12-12 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
CN1674918A (zh) * | 2002-06-12 | 2005-09-28 | 埃匹吉尼斯医药有限公司 | 利用脱氢表雄酮甾体及抗毒蕈碱药物治疗呼吸道疾病及肺病的组合物、制剂和试剂盒 |
US7056916B2 (en) * | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
KR20050085650A (ko) * | 2002-12-16 | 2005-08-29 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 타이오트로피움 함유 hfc 용액 제형 |
US20050058606A1 (en) * | 2002-12-16 | 2005-03-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing HFC solution formulations |
EP1915985A1 (en) * | 2003-03-20 | 2008-04-30 | Boehringer Ingelheim Pharmaceuticals Inc. | Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants |
ME00420B (me) * | 2003-03-20 | 2011-12-20 | Boehringer Ingelheim Pharmaceuticals Inc | Formulacija, za inhalator u kojem se odmjerava doza, u kojoj se kao propelenti koriste hidro-fluoro-alkani |
US7273603B2 (en) | 2003-07-11 | 2007-09-25 | Boehringer Ingelheim International Gmbh | HFC solution formulations containing an anticholinergic |
US20050026948A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
US20050101545A1 (en) * | 2003-07-31 | 2005-05-12 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
US20050026882A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
US20090317476A1 (en) * | 2003-07-31 | 2009-12-24 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease |
AR041873A1 (es) * | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante |
EP1595531A1 (en) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
KR20070000476A (ko) * | 2004-02-27 | 2007-01-02 | 키에시 파르마슈티시 엣스. 피. 에이. | 압축화 계량된 도스흡입용 안정된 약제용액 제제 |
US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
DK1809243T4 (da) * | 2004-07-02 | 2022-09-05 | Boehringer Ingelheim Int | Aerosolsuspensionsformuleringer med tg 227 ea som drivmiddel |
GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
MX2007010396A (es) * | 2005-02-25 | 2007-10-19 | Chiesi Farma Spa | Formulaciones farmaceuticas en aerosol para inhaladores presurizados de dosis medida que comprenden un agente secuestrante. |
CA2607391A1 (en) * | 2005-04-23 | 2006-11-02 | Boehringer Ingelheim International Gmbh | Combination of medicaments to be inhaled, containing a betamimetic agent and a steroid in addition to an anticholinergic agent |
AU2006243238B2 (en) | 2005-05-02 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
ES2530991T3 (es) * | 2005-08-15 | 2015-03-09 | Boehringer Ingelheim Int | Procedimiento para la obtención de betamiméticos |
WO2007034207A2 (en) * | 2005-09-25 | 2007-03-29 | Cipla Limited | Troventol formulation |
TWI396541B (zh) * | 2005-10-10 | 2013-05-21 | Boehringer Ingelheim Int | 用於治療呼吸疾病之新穎藥物組合 |
US20070088030A1 (en) * | 2005-10-10 | 2007-04-19 | Barbara Niklaus-Humke | Aerosol formulations for the inhalation of beta-agonists |
DE102006017320A1 (de) | 2006-04-11 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel |
DE102006023770A1 (de) * | 2006-05-20 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treibgasfreie Aerosolformulierung für die Inhalation |
WO2008008494A2 (en) * | 2006-07-13 | 2008-01-17 | Accentia Biopharmaceuticals, Inc. | Methods and compositions for treating mucosal inflammation |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2201934A1 (en) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
EP3508239B1 (de) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
KR20120109504A (ko) | 2009-11-17 | 2012-10-08 | 시플라 리미티드 | 흡입 용액 |
UA107097C2 (en) | 2009-11-25 | 2014-11-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Dispenser |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
EP3020393B1 (en) | 2009-12-16 | 2020-10-07 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
WO2011076842A2 (en) | 2009-12-23 | 2011-06-30 | Chiesi Farmaceutici S.P.A. | Aerosol formulation for copd |
EP2515855B3 (en) * | 2009-12-23 | 2023-05-03 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
JP5409594B2 (ja) * | 2010-12-22 | 2014-02-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
US20120204871A1 (en) * | 2011-02-10 | 2012-08-16 | Julio Cesar Vega | Stable, non-corrosive formulations for pressurized metered dose inhalers |
EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
GB201200504D0 (en) | 2011-12-19 | 2012-02-22 | Teva Branded Pharmaceutical Prod R & D Inc | An inhaler |
WO2013127738A1 (de) * | 2012-02-28 | 2013-09-06 | Boehringer Ingelheim International Gmbh | Neue treibgashaltige tiotropium-formulierung |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
RU2496477C1 (ru) * | 2012-09-20 | 2013-10-27 | Шолекс Девелопмент Гмбх | Раствор ипратропия бромида |
EP3030298B1 (en) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nebulizer |
ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
RU2536253C1 (ru) * | 2013-10-09 | 2014-12-20 | Шолекс Девелопмент Гмбх | Комбинированный аэрозольный препарат для лечения болезней органов дыхания |
EA201691067A1 (ru) * | 2013-11-22 | 2016-09-30 | Тева Брэндид Фармасьютикал Продактс Ар Энд Ди, Инк. | Ингалируемое лекарственное средство |
DK2897589T3 (en) * | 2013-11-22 | 2018-03-12 | Teva Branded Pharmaceutical Prod R & D Inc | Inhalable drug |
ES2954961T3 (es) | 2014-05-07 | 2023-11-27 | Boehringer Ingelheim Int | Unidad, nebulizador y método |
UA121114C2 (uk) | 2014-05-07 | 2020-04-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Небулайзер, індикаторний пристрій і контейнер |
ES2874029T3 (es) | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizador |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
RU2577289C1 (ru) * | 2015-03-26 | 2016-03-10 | Шолекс Девелопмент Гмбх | Аэрозольный препарат на основе фенотерола гидробромида для лечения заболеваний органов дыхания |
JP6781831B2 (ja) * | 2016-09-19 | 2020-11-04 | メキシケム フロー エセ・ア・デ・セ・ヴェ | 医薬組成物 |
EP3569221A1 (en) * | 2018-05-17 | 2019-11-20 | Notoxins IP B.V. | Aqueous formulations comprising ipratropium for topical treatment of hyperhidrosis |
WO2020152548A1 (en) * | 2019-01-24 | 2020-07-30 | Glenmark Pharmaceuticals Limited | Stable aerosol inhalation compositions of formoterol |
GB2584686A (en) * | 2019-06-11 | 2020-12-16 | Mexichem Fluor Sa De Cv | Methods |
CN111297835B (zh) * | 2019-12-20 | 2022-11-25 | 上海方予健康医药科技有限公司 | 含抗胆碱能药物的吸入气雾剂及其制备工艺和使用方法 |
PE20240629A1 (es) * | 2020-10-09 | 2024-03-26 | Chiesi Farm Spa | Formulacion farmaceutica para inhalador presurizado de dosis medidas |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE555319A (sv) * | 1956-03-21 | 1900-01-01 | ||
US3282781A (en) * | 1960-11-25 | 1966-11-01 | Merck & Co Inc | Inhalant compositions |
CA1178889A (en) * | 1980-08-28 | 1984-12-04 | Kenneth S. Su | Intranasal formulation |
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
GB8900267D0 (en) * | 1989-01-06 | 1989-03-08 | Riker Laboratories Inc | Narcotic analgesic formulations and apparatus containing same |
US5439670A (en) * | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
DE4003272A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
US5118494A (en) * | 1990-03-23 | 1992-06-02 | Minnesota Mining And Manufacturing Company | Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
US5190029A (en) * | 1991-02-14 | 1993-03-02 | Virginia Commonwealth University | Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
PT656207E (pt) * | 1991-06-10 | 2001-11-30 | Schering Corp | Formulacoes de aerossois sem clorofluorocarbonetos |
IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
WO1994013262A1 (en) * | 1992-12-09 | 1994-06-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stabilized medicinal aerosol solution formulations |
US5837699A (en) * | 1994-01-27 | 1998-11-17 | Schering Corporation | Use of mometasone furoate for treating upper airway passage diseases |
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1993
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- 1993-12-06 WO PCT/US1993/011856 patent/WO1994013263A1/en active Application Filing
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