FI113861B - Parannettu menetelmä 6,9-bis[(2-aminoetyyli)amino]bentso[g]-isokinoliini-5,10-dionin ja sen dimaleaattisuolan syntetisoimiseksi - Google Patents

Parannettu menetelmä 6,9-bis[(2-aminoetyyli)amino]bentso[g]-isokinoliini-5,10-dionin ja sen dimaleaattisuolan syntetisoimiseksi Download PDF

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Publication number
FI113861B
FI113861B FI963864A FI963864A FI113861B FI 113861 B FI113861 B FI 113861B FI 963864 A FI963864 A FI 963864A FI 963864 A FI963864 A FI 963864A FI 113861 B FI113861 B FI 113861B
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FI
Finland
Prior art keywords
dione
isoquinoline
amino
bis
benzo
Prior art date
Application number
FI963864A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963864A0 (fi
FI963864A (fi
Inventor
Silvano Spinelli
Roberto Didomenico
Original Assignee
Novuspharma Spa
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Publication date
Application filed by Novuspharma Spa filed Critical Novuspharma Spa
Publication of FI963864A0 publication Critical patent/FI963864A0/fi
Publication of FI963864A publication Critical patent/FI963864A/fi
Application granted granted Critical
Publication of FI113861B publication Critical patent/FI113861B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
FI963864A 1994-03-28 1996-09-27 Parannettu menetelmä 6,9-bis[(2-aminoetyyli)amino]bentso[g]-isokinoliini-5,10-dionin ja sen dimaleaattisuolan syntetisoimiseksi FI113861B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/220,007 US5506232A (en) 1994-03-28 1994-03-28 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
US22000794 1994-03-28
IB9500230 1995-03-27
PCT/IB1995/000230 WO1995026189A1 (en) 1994-03-28 1995-03-27 AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT

Publications (3)

Publication Number Publication Date
FI963864A0 FI963864A0 (fi) 1996-09-27
FI963864A FI963864A (fi) 1996-09-27
FI113861B true FI113861B (fi) 2004-06-30

Family

ID=22821665

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963864A FI113861B (fi) 1994-03-28 1996-09-27 Parannettu menetelmä 6,9-bis[(2-aminoetyyli)amino]bentso[g]-isokinoliini-5,10-dionin ja sen dimaleaattisuolan syntetisoimiseksi

Country Status (24)

Country Link
US (3) US5506232A (zh)
EP (1) EP0752857B1 (zh)
JP (2) JP3151462B2 (zh)
KR (1) KR100224153B1 (zh)
CN (2) CN1130199C (zh)
AT (1) ATE203408T1 (zh)
AU (1) AU679627B2 (zh)
BR (1) BR9507257A (zh)
CA (1) CA2186485C (zh)
CZ (2) CZ598A3 (zh)
DE (1) DE69521887T2 (zh)
DK (1) DK0752857T3 (zh)
ES (1) ES2159313T3 (zh)
FI (1) FI113861B (zh)
GR (1) GR3037014T3 (zh)
HU (1) HU223311B1 (zh)
LU (1) LU92089I2 (zh)
NO (2) NO307564B1 (zh)
NZ (1) NZ282480A (zh)
PT (1) PT752857E (zh)
RU (1) RU2144028C1 (zh)
TW (1) TW397826B (zh)
WO (1) WO1995026189A1 (zh)
ZA (1) ZA952477B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
NZ286951A (en) * 1995-07-13 1998-02-26 Anormed Inc Substituted Under N-n-diethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
IT1315253B1 (it) * 1999-10-22 2003-02-03 Novuspharma Spa Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino|benzog|isochinolin-5,10-dione dimaleato
US20050222190A1 (en) * 2004-03-30 2005-10-06 Curd John G 1,4-bis-N-oxide azaanthracenediones and the use thereof
WO2008042611A2 (en) * 2006-09-29 2008-04-10 Centocor, Inc. Method of using il6 antagonists with mitoxantrone for prostate cancer
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) * 2018-09-04 2022-05-17 北京凯莱天成医药科技有限公司 一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920754A1 (en) * 1991-03-08 1992-09-09 Univ Vermont 6,9 BIS(SUBSTITUTED-AMINO) BENZO[g]-ISOQUINOLINE-5,10-DIONES
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

Also Published As

Publication number Publication date
CZ276796A3 (en) 1997-02-12
JP3151462B2 (ja) 2001-04-03
HU223311B1 (hu) 2004-05-28
CN1130199C (zh) 2003-12-10
MX9603994A (es) 1997-12-31
AU679627B2 (en) 1997-07-03
CA2186485C (en) 1999-12-14
CZ285139B6 (cs) 1999-05-12
US5506232A (en) 1996-04-09
CN1282738A (zh) 2001-02-07
PT752857E (pt) 2001-11-30
HUT75654A (en) 1997-05-28
AU1958995A (en) 1995-10-17
CZ598A3 (cs) 1999-05-12
ES2159313T3 (es) 2001-10-01
DK0752857T3 (da) 2001-09-24
CA2186485A1 (en) 1995-10-05
WO1995026189A1 (en) 1995-10-05
NO307564B1 (no) 2000-04-25
EP0752857A1 (en) 1997-01-15
JP2001089454A (ja) 2001-04-03
GR3037014T3 (en) 2002-01-31
EP0752857B1 (en) 2001-07-25
ATE203408T1 (de) 2001-08-15
KR100224153B1 (ko) 1999-10-15
ZA952477B (en) 1996-09-27
RU2144028C1 (ru) 2000-01-10
LU92089I2 (fr) 2012-12-27
US5717099A (en) 1998-02-10
BR9507257A (pt) 1997-10-07
FI963864A0 (fi) 1996-09-27
NO2012020I1 (no) 2012-12-27
NZ282480A (en) 1997-04-24
JPH09507674A (ja) 1997-08-05
JP3548099B2 (ja) 2004-07-28
CZ284937B6 (cs) 1999-04-14
DE69521887T2 (de) 2001-11-22
DE69521887D1 (de) 2001-08-30
NO964082D0 (no) 1996-09-27
CN1145028A (zh) 1997-03-12
NO2012020I2 (no) 2013-11-11
US5616709A (en) 1997-04-01
TW397826B (en) 2000-07-11
FI963864A (fi) 1996-09-27
NO964082L (no) 1996-09-27
HU9602655D0 (en) 1996-11-28

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