FI113050B - 2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä - Google Patents

2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä Download PDF

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Publication number
FI113050B
FI113050B FI971854A FI971854A FI113050B FI 113050 B FI113050 B FI 113050B FI 971854 A FI971854 A FI 971854A FI 971854 A FI971854 A FI 971854A FI 113050 B FI113050 B FI 113050B
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Finland
Prior art keywords
alkyl
eller
methyl
hydrogen
formula
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Application number
FI971854A
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English (en)
Finnish (fi)
Swedish (sv)
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FI971854A (fi
FI971854A0 (fi
Inventor
Francisco Javi Fernandez-Gadea
Victor Karel Sipido
Jose Ignacio Andres-Gil
Theo Frans Meert
Pilar Gil-Lopetegui
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Janssen Pharmaceutica Nv
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Publication of FI971854A publication Critical patent/FI971854A/fi
Publication of FI971854A0 publication Critical patent/FI971854A0/fi
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Publication of FI113050B publication Critical patent/FI113050B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI971854A 1994-11-02 1997-04-30 2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä FI113050B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP94203178 1994-11-02
EP94203178 1994-11-02
US08/457,968 US5552399A (en) 1994-11-02 1995-05-31 Substituted tetracyclic azepine derivatives
US45796895 1995-05-31
EP9504196 1995-10-25
PCT/EP1995/004196 WO1996014320A1 (en) 1994-11-02 1995-10-25 Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors

Publications (3)

Publication Number Publication Date
FI971854A FI971854A (fi) 1997-04-30
FI971854A0 FI971854A0 (fi) 1997-04-30
FI113050B true FI113050B (fi) 2004-02-27

Family

ID=8217337

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971854A FI113050B (fi) 1994-11-02 1997-04-30 2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä

Country Status (30)

Country Link
US (1) US5552399A (ko)
EP (1) EP0789701B1 (ko)
JP (1) JP3818541B2 (ko)
KR (1) KR100392060B1 (ko)
CN (1) CN1085667C (ko)
AR (1) AR002238A1 (ko)
AT (1) ATE199087T1 (ko)
AU (1) AU704285B2 (ko)
BR (1) BR9509552A (ko)
CA (1) CA2203661A1 (ko)
CZ (1) CZ286945B6 (ko)
DE (1) DE69520070T2 (ko)
DK (1) DK0789701T3 (ko)
ES (1) ES2155898T3 (ko)
FI (1) FI113050B (ko)
GR (1) GR3035680T3 (ko)
HR (1) HRP950537A2 (ko)
HU (1) HUT77408A (ko)
IL (1) IL115819A (ko)
MY (1) MY113325A (ko)
NO (1) NO308035B1 (ko)
NZ (1) NZ295656A (ko)
PL (1) PL183686B1 (ko)
PT (1) PT789701E (ko)
RU (1) RU2163240C2 (ko)
SI (1) SI0789701T1 (ko)
TR (1) TR199501356A2 (ko)
TW (1) TW349950B (ko)
WO (1) WO1996014320A1 (ko)
ZA (1) ZA959215B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ329954A (en) * 1996-04-12 1999-07-29 Janssen Pharmaceutica Nv Isoxazolidine tetracyclic and tricyclic ring system derivatives and medicaments
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
CA3069699A1 (en) * 2017-07-13 2019-01-17 Tonix Pharmaceuticals Holding Corp. Analogs of cyclobenzaprine and amitryptilene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (de) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) * 1975-10-21 1977-05-05 Hans Fickler Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine
RU2048469C1 (ru) * 1989-10-05 1995-11-20 Санкио Компани Лимитед Способ получения азетидинового производного или его фармацевтически приемлемой соли
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
GR3035680T3 (en) 2001-06-29
CA2203661A1 (en) 1996-05-17
ZA959215B (en) 1997-04-30
MY113325A (en) 2002-01-31
CZ286945B6 (en) 2000-08-16
KR100392060B1 (ko) 2003-11-28
NO308035B1 (no) 2000-07-10
ATE199087T1 (de) 2001-02-15
EP0789701B1 (en) 2001-02-07
DK0789701T3 (da) 2001-06-18
HRP950537A2 (en) 1997-08-31
US5552399A (en) 1996-09-03
WO1996014320A1 (en) 1996-05-17
IL115819A0 (en) 1996-01-19
FI971854A (fi) 1997-04-30
AR002238A1 (es) 1998-03-11
RU2163240C2 (ru) 2001-02-20
AU704285B2 (en) 1999-04-15
CN1085667C (zh) 2002-05-29
PL183686B1 (pl) 2002-06-28
PT789701E (pt) 2001-07-31
JP3818541B2 (ja) 2006-09-06
DE69520070D1 (de) 2001-03-15
CN1162313A (zh) 1997-10-15
TR199501356A2 (tr) 1996-06-21
JPH10508308A (ja) 1998-08-18
ES2155898T3 (es) 2001-06-01
HUT77408A (hu) 1998-04-28
TW349950B (en) 1999-01-11
PL319939A1 (en) 1997-09-01
NO972017L (no) 1997-04-30
IL115819A (en) 1998-10-30
CZ132397A3 (cs) 1998-01-14
MX9703255A (es) 1997-07-31
NZ295656A (en) 1998-10-28
NO972017D0 (no) 1997-04-30
BR9509552A (pt) 1997-09-16
EP0789701A1 (en) 1997-08-20
AU3924995A (en) 1996-05-31
SI0789701T1 (en) 2001-08-31
DE69520070T2 (de) 2001-09-13
FI971854A0 (fi) 1997-04-30

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