FI112377B - Entsymaattinen hydrolyysimenetelmä C-10- ja C-13-asemaan liittyvän hydroksyyliryhmän sisältävien taksaanien valmistamiseksi, entsymaattinen esteröintimenetelmä C-10-asemaan liittyvän asyylioksiryhmänsisältävien taksaanien valmistamiseksi ja mainittujen yhdisteiden käyttö C13-asemaan liittyvän asyylioksiryhmän sisältävien taksaanien valmistamiseksi - Google Patents

Entsymaattinen hydrolyysimenetelmä C-10- ja C-13-asemaan liittyvän hydroksyyliryhmän sisältävien taksaanien valmistamiseksi, entsymaattinen esteröintimenetelmä C-10-asemaan liittyvän asyylioksiryhmänsisältävien taksaanien valmistamiseksi ja mainittujen yhdisteiden käyttö C13-asemaan liittyvän asyylioksiryhmän sisältävien taksaanien valmistamiseksi Download PDF

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Publication number
FI112377B
FI112377B FI942794A FI942794A FI112377B FI 112377 B FI112377 B FI 112377B FI 942794 A FI942794 A FI 942794A FI 942794 A FI942794 A FI 942794A FI 112377 B FI112377 B FI 112377B
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Prior art keywords
nocardioides
microorganism
taxane
group
enzyme
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FI942794A
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English (en)
Finnish (fi)
Swedish (sv)
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FI942794A0 (fi
FI942794A (fi
Inventor
Ronald L Hanson
Ramesh N Patel
Laszlo J Szarka
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Squibb Bristol Myers Co
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Priority claimed from US08/077,979 external-priority patent/US5516676A/en
Priority claimed from US08/077,980 external-priority patent/US5523219A/en
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of FI942794A0 publication Critical patent/FI942794A0/fi
Publication of FI942794A publication Critical patent/FI942794A/fi
Application granted granted Critical
Publication of FI112377B publication Critical patent/FI112377B/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2407/00—Assays, e.g. immunoassays or enzyme assays, involving terpenes
    • G01N2407/02—Taxol; Taxanes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI942794A 1993-06-15 1994-06-13 Entsymaattinen hydrolyysimenetelmä C-10- ja C-13-asemaan liittyvän hydroksyyliryhmän sisältävien taksaanien valmistamiseksi, entsymaattinen esteröintimenetelmä C-10-asemaan liittyvän asyylioksiryhmänsisältävien taksaanien valmistamiseksi ja mainittujen yhdisteiden käyttö C13-asemaan liittyvän asyylioksiryhmän sisältävien taksaanien valmistamiseksi FI112377B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7797993 1993-06-15
US08/077,979 US5516676A (en) 1993-06-15 1993-06-15 Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US7798093 1993-06-15
US08/077,980 US5523219A (en) 1993-06-15 1993-06-15 Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing

Publications (3)

Publication Number Publication Date
FI942794A0 FI942794A0 (fi) 1994-06-13
FI942794A FI942794A (fi) 1994-12-16
FI112377B true FI112377B (fi) 2003-11-28

Family

ID=26759913

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942794A FI112377B (fi) 1993-06-15 1994-06-13 Entsymaattinen hydrolyysimenetelmä C-10- ja C-13-asemaan liittyvän hydroksyyliryhmän sisältävien taksaanien valmistamiseksi, entsymaattinen esteröintimenetelmä C-10-asemaan liittyvän asyylioksiryhmänsisältävien taksaanien valmistamiseksi ja mainittujen yhdisteiden käyttö C13-asemaan liittyvän asyylioksiryhmän sisältävien taksaanien valmistamiseksi

Country Status (18)

Country Link
EP (1) EP0629701B1 (ja)
JP (1) JP3587880B2 (ja)
KR (1) KR100342624B1 (ja)
CN (1) CN1110565C (ja)
AT (1) ATE189001T1 (ja)
AU (1) AU679978B2 (ja)
CA (1) CA2125726A1 (ja)
CY (1) CY2205B1 (ja)
DE (1) DE69422662T2 (ja)
DK (1) DK0629701T3 (ja)
ES (1) ES2142890T3 (ja)
FI (1) FI112377B (ja)
GR (1) GR3032990T3 (ja)
HK (1) HK1014742A1 (ja)
HU (1) HU217218B (ja)
IL (1) IL109926A (ja)
PT (1) PT629701E (ja)
SG (1) SG54139A1 (ja)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
DK0875508T3 (da) * 1997-05-02 2004-01-26 Pharmachemie Bv Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE19962204A1 (de) * 1999-12-22 2001-07-05 Cognis Deutschland Gmbh Enzym-katalysierte Modifizierung von Substanzen in biologischen Gemischen
RU2265019C2 (ru) 2000-02-02 2005-11-27 Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. Таксаны, фармацевтические композиции, способы ингибирования
IL145640A (en) 2000-02-02 2007-02-11 Univ Florida State Res Found Texans are converted to C10 in myamloxy as anti-cancer agents
DE60133600T2 (de) 2000-02-02 2009-06-10 Florida State University Research Foundation, Inc., Tallahassee C7-carbamoyloxysubstituierte taxane als antitumormittel
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
JP2003521514A (ja) 2000-02-02 2003-07-15 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０ヘテロ置換アセテートタキサン
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
WO2001057029A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
EP1298128B1 (en) * 2001-09-28 2005-03-02 Council Of Scientific And Industrial Research Process for the preparation of 10-deacetylbaccatin III
US6437154B1 (en) 2001-09-28 2002-08-20 Council Of Scientific And Industrial Research Process for the preparation of 10-deacetylbaccatin III
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
JP2007527432A (ja) 2004-03-05 2007-09-27 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ７ラクチルオキシ置換タキサン
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
US8242166B2 (en) 2008-03-31 2012-08-14 Florida State University Research Foundation, Inc. C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes
CN106148471A (zh) * 2015-04-08 2016-11-23 中国科学院大连化学物理研究所 一种纤维单胞菌科作为工业生物催化剂的应用
CN105541763A (zh) * 2016-03-03 2016-05-04 重庆市碚圣医药科技股份有限公司 三尖杉宁碱水解制备10-脱乙酰基巴卡丁iii的方法
CN107164422B (zh) * 2016-03-08 2021-01-22 复旦大学 续随子二萜醇衍生物的转化方法及其在制备抗肿瘤药物中的用途
CN111394270B (zh) * 2018-12-27 2022-04-05 中国农业科学院农业资源与农业区划研究所 一株藤黄类诺卡氏菌及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Also Published As

Publication number Publication date
IL109926A (en) 2000-02-29
EP0629701A1 (en) 1994-12-21
JP3587880B2 (ja) 2004-11-10
KR950000887A (ko) 1995-01-03
PT629701E (pt) 2000-06-30
HU9401767D0 (en) 1994-09-28
DE69422662D1 (de) 2000-02-24
GR3032990T3 (en) 2000-07-31
ATE189001T1 (de) 2000-02-15
HK1014742A1 (en) 1999-09-30
SG54139A1 (en) 1998-11-16
CN1110565C (zh) 2003-06-04
FI942794A0 (fi) 1994-06-13
AU679978B2 (en) 1997-07-17
HUT71191A (en) 1995-11-28
EP0629701B1 (en) 2000-01-19
IL109926A0 (en) 1994-10-07
CA2125726A1 (en) 1994-12-16
CY2205B1 (en) 2002-11-08
DE69422662T2 (de) 2000-07-20
FI942794A (fi) 1994-12-16
DK0629701T3 (da) 2000-04-17
AU6467194A (en) 1994-12-22
KR100342624B1 (ko) 2002-11-18
HU217218B (hu) 1999-12-28
JPH0751078A (ja) 1995-02-28
CN1101944A (zh) 1995-04-26
ES2142890T3 (es) 2000-05-01

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