IL109926A - Methods for the preparation of taxanes and microorganisms and enzymes utilized therein - Google Patents

Methods for the preparation of taxanes and microorganisms and enzymes utilized therein

Info

Publication number
IL109926A
IL109926A IL10992694A IL10992694A IL109926A IL 109926 A IL109926 A IL 109926A IL 10992694 A IL10992694 A IL 10992694A IL 10992694 A IL10992694 A IL 10992694A IL 109926 A IL109926 A IL 109926A
Authority
IL
Israel
Prior art keywords
taxanes
preparation
acyloxy
methods
groups
Prior art date
Application number
IL10992694A
Other languages
English (en)
Other versions
IL109926A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/077,979 external-priority patent/US5516676A/en
Priority claimed from US08/077,980 external-priority patent/US5523219A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to IL13062394A priority Critical patent/IL130623A/en
Priority to IL13062194A priority patent/IL130621A/en
Priority to IL13062094A priority patent/IL130620A/xx
Publication of IL109926A0 publication Critical patent/IL109926A0/xx
Publication of IL109926A publication Critical patent/IL109926A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2407/00—Assays, e.g. immunoassays or enzyme assays, involving terpenes
    • G01N2407/02—Taxol; Taxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL10992694A 1993-06-15 1994-06-07 Methods for the preparation of taxanes and microorganisms and enzymes utilized therein IL109926A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL13062394A IL130623A (en) 1993-06-15 1994-06-07 Methods for preparation of taxanes and microorganisms and enzymes utilized therein
IL13062194A IL130621A (en) 1993-06-15 1994-06-07 Methods for preparation of taxanes and microorganisms and enzymes utilized therein
IL13062094A IL130620A (en) 1993-06-15 1994-06-07 Method for selecting microorganisms and enzymes isolated therefrom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/077,979 US5516676A (en) 1993-06-15 1993-06-15 Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US08/077,980 US5523219A (en) 1993-06-15 1993-06-15 Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing

Publications (2)

Publication Number Publication Date
IL109926A0 IL109926A0 (en) 1994-10-07
IL109926A true IL109926A (en) 2000-02-29

Family

ID=26759913

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10992694A IL109926A (en) 1993-06-15 1994-06-07 Methods for the preparation of taxanes and microorganisms and enzymes utilized therein

Country Status (18)

Country Link
EP (1) EP0629701B1 (xx)
JP (1) JP3587880B2 (xx)
KR (1) KR100342624B1 (xx)
CN (1) CN1110565C (xx)
AT (1) ATE189001T1 (xx)
AU (1) AU679978B2 (xx)
CA (1) CA2125726A1 (xx)
CY (1) CY2205B1 (xx)
DE (1) DE69422662T2 (xx)
DK (1) DK0629701T3 (xx)
ES (1) ES2142890T3 (xx)
FI (1) FI112377B (xx)
GR (1) GR3032990T3 (xx)
HK (1) HK1014742A1 (xx)
HU (1) HU217218B (xx)
IL (1) IL109926A (xx)
PT (1) PT629701E (xx)
SG (1) SG54139A1 (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
DK0875508T3 (da) * 1997-05-02 2004-01-26 Pharmachemie Bv Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE19962204A1 (de) * 1999-12-22 2001-07-05 Cognis Deutschland Gmbh Enzym-katalysierte Modifizierung von Substanzen in biologischen Gemischen
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
AU776122B2 (en) 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
CN1186340C (zh) 2000-02-02 2005-01-26 佛罗里达州立大学研究基金有限公司 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷
KR20020002488A (ko) 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서 ｃ10 헤테로치환된 아세테이트 탁산
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
DK1165549T3 (da) 2000-02-02 2008-08-11 Univ Florida State Res Found C7 carbamoyloxy-substituerede taxaner som antitumormidler
AU776765B2 (en) 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
AU783422B2 (en) 2000-02-02 2005-10-27 Florida State University Research Foundation, Inc. C10 carbamoyloxy substituted taxanes as antitumor agents
EP1298128B1 (en) * 2001-09-28 2005-03-02 Council Of Scientific And Industrial Research Process for the preparation of 10-deacetylbaccatin III
US6437154B1 (en) 2001-09-28 2002-08-20 Council Of Scientific And Industrial Research Process for the preparation of 10-deacetylbaccatin III
PE20050693A1 (es) 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
CN106148471A (zh) * 2015-04-08 2016-11-23 中国科学院大连化学物理研究所 一种纤维单胞菌科作为工业生物催化剂的应用
CN105541763A (zh) * 2016-03-03 2016-05-04 重庆市碚圣医药科技股份有限公司 三尖杉宁碱水解制备10-脱乙酰基巴卡丁iii的方法
CN107164422B (zh) * 2016-03-08 2021-01-22 复旦大学 续随子二萜醇衍生物的转化方法及其在制备抗肿瘤药物中的用途
CN111394270B (zh) * 2018-12-27 2022-04-05 中国农业科学院农业资源与农业区划研究所 一株藤黄类诺卡氏菌及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Also Published As

Publication number Publication date
ES2142890T3 (es) 2000-05-01
CY2205B1 (en) 2002-11-08
HUT71191A (en) 1995-11-28
KR950000887A (ko) 1995-01-03
PT629701E (pt) 2000-06-30
AU6467194A (en) 1994-12-22
FI112377B (fi) 2003-11-28
HU217218B (hu) 1999-12-28
DE69422662D1 (de) 2000-02-24
SG54139A1 (en) 1998-11-16
GR3032990T3 (en) 2000-07-31
FI942794A (fi) 1994-12-16
JP3587880B2 (ja) 2004-11-10
DK0629701T3 (da) 2000-04-17
EP0629701A1 (en) 1994-12-21
ATE189001T1 (de) 2000-02-15
HK1014742A1 (en) 1999-09-30
KR100342624B1 (ko) 2002-11-18
AU679978B2 (en) 1997-07-17
EP0629701B1 (en) 2000-01-19
IL109926A0 (en) 1994-10-07
DE69422662T2 (de) 2000-07-20
CN1110565C (zh) 2003-06-04
HU9401767D0 (en) 1994-09-28
CN1101944A (zh) 1995-04-26
FI942794A0 (fi) 1994-06-13
CA2125726A1 (en) 1994-12-16
JPH0751078A (ja) 1995-02-28

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