ES2142890T3 - Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13. - Google Patents

Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13.

Info

Publication number
ES2142890T3
ES2142890T3 ES94108957T ES94108957T ES2142890T3 ES 2142890 T3 ES2142890 T3 ES 2142890T3 ES 94108957 T ES94108957 T ES 94108957T ES 94108957 T ES94108957 T ES 94108957T ES 2142890 T3 ES2142890 T3 ES 2142890T3
Authority
ES
Spain
Prior art keywords
taxanes
preparation
groups
enzymatic
hydroxyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94108957T
Other languages
English (en)
Inventor
Ronald L Hanson
Ramesh N Patel
Laszlo J Szarka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/077,979 external-priority patent/US5516676A/en
Priority claimed from US08/077,980 external-priority patent/US5523219A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2142890T3 publication Critical patent/ES2142890T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2407/00—Assays, e.g. immunoassays or enzyme assays, involving terpenes
    • G01N2407/02—Taxol; Taxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

UN METODO DE HIDROLISIS ENZIMATICA, EN EL QUE UNO O MAS TAXANOS QUE CONTIENEN ACILOXI C-10 CONTACTAN CON UNA ENZIMA O MICROORGANISMO CAPAZ DE HIDROLIZAR LOS CITADOS GRUPOS DE ACILOXI A GRUPOS DE HIDROXILO. TAMBIEN SE PROPORCIONA UN METODO DE ESTERIFICACION ENZIMATICA, DONDE UNO O MAS TAXANOS QUE CONTIENEN HIDROXILO C-10 CONTACTAN CON UN AGENTE DE ACILO Y UNA ENZYMA O MICROORGANISMO CAPAZ DE ESTERIFICAR LOS CITADOS GRUPOS DE HIDROXILO, PARA FORMAR GRUPOS DE ACILOXI. ADEMAS SE PROPORCIONA UN METODO DE HIDROLISIS ENZIMATICA, DONDE UNO O MAS TAXANOS QUE CONTIENEN ACILOXI C-13 CONTACTAN CON UNA ENZYMA O MICROORGANISMO CAPAZ DE HIDROLIZAR LOS CITADOS GRUPOS DE ACILOXI A GRUPOS DE HIDROXIL. LOS METODOS SON ESPECIALMENTE UTILES PARA LA PREPARACION DE COMPUESTOS QUE PUEDEN EMPLEARSE COMO PRODUCTOS INTERMEDIOS EN LA PREPARACION DE TAXANOS TALES COMO TAXOL.
ES94108957T 1993-06-15 1994-06-10 Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13. Expired - Lifetime ES2142890T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/077,979 US5516676A (en) 1993-06-15 1993-06-15 Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US08/077,980 US5523219A (en) 1993-06-15 1993-06-15 Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing

Publications (1)

Publication Number Publication Date
ES2142890T3 true ES2142890T3 (es) 2000-05-01

Family

ID=26759913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94108957T Expired - Lifetime ES2142890T3 (es) 1993-06-15 1994-06-10 Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13.

Country Status (18)

Country Link
EP (1) EP0629701B1 (es)
JP (1) JP3587880B2 (es)
KR (1) KR100342624B1 (es)
CN (1) CN1110565C (es)
AT (1) ATE189001T1 (es)
AU (1) AU679978B2 (es)
CA (1) CA2125726A1 (es)
CY (1) CY2205B1 (es)
DE (1) DE69422662T2 (es)
DK (1) DK0629701T3 (es)
ES (1) ES2142890T3 (es)
FI (1) FI112377B (es)
GR (1) GR3032990T3 (es)
HK (1) HK1014742A1 (es)
HU (1) HU217218B (es)
IL (1) IL109926A (es)
PT (1) PT629701E (es)
SG (1) SG54139A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
SI0875508T1 (en) * 1997-05-02 2004-04-30 Pharmachemie B.V. Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE19962204A1 (de) * 1999-12-22 2001-07-05 Cognis Deutschland Gmbh Enzym-katalysierte Modifizierung von Substanzen in biologischen Gemischen
HUP0200750A3 (en) 2000-02-02 2005-02-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use
EP1165551B1 (en) 2000-02-02 2008-07-16 Florida State University Research Foundation, Inc. C10 carbamoyloxy substituted taxanes as antitumor agents
KR20020002417A (ko) 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ7 카르바모일옥시 치환된 탁산
CZ20013429A3 (cs) 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany substituované v poloze C7 karbonátem jako protinádorová činidla
HUP0200759A3 (en) 2000-02-02 2002-10-28 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
AU776765B2 (en) 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
DE60109165T2 (de) * 2001-09-28 2006-02-16 Council Of Scientific And Industrial Research Verfahren zur Herstellung von 10-Desacetylbaccatin III
US6437154B1 (en) 2001-09-28 2002-08-20 Council Of Scientific And Industrial Research Process for the preparation of 10-deacetylbaccatin III
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
GT200500041A (es) 2004-03-05 2005-10-24 Taxanos con sustituyente lactiloxilo en el c7
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
CN106148471A (zh) * 2015-04-08 2016-11-23 中国科学院大连化学物理研究所 一种纤维单胞菌科作为工业生物催化剂的应用
CN105541763A (zh) * 2016-03-03 2016-05-04 重庆市碚圣医药科技股份有限公司 三尖杉宁碱水解制备10-脱乙酰基巴卡丁iii的方法
CN107164422B (zh) * 2016-03-08 2021-01-22 复旦大学 续随子二萜醇衍生物的转化方法及其在制备抗肿瘤药物中的用途
CN111394270B (zh) * 2018-12-27 2022-04-05 中国农业科学院农业资源与农业区划研究所 一株藤黄类诺卡氏菌及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Also Published As

Publication number Publication date
IL109926A0 (en) 1994-10-07
KR100342624B1 (ko) 2002-11-18
HU9401767D0 (en) 1994-09-28
HK1014742A1 (en) 1999-09-30
KR950000887A (ko) 1995-01-03
EP0629701A1 (en) 1994-12-21
CY2205B1 (en) 2002-11-08
DE69422662T2 (de) 2000-07-20
ATE189001T1 (de) 2000-02-15
CA2125726A1 (en) 1994-12-16
DE69422662D1 (de) 2000-02-24
FI942794A0 (fi) 1994-06-13
AU679978B2 (en) 1997-07-17
CN1110565C (zh) 2003-06-04
JPH0751078A (ja) 1995-02-28
EP0629701B1 (en) 2000-01-19
FI942794A (fi) 1994-12-16
JP3587880B2 (ja) 2004-11-10
CN1101944A (zh) 1995-04-26
AU6467194A (en) 1994-12-22
FI112377B (fi) 2003-11-28
DK0629701T3 (da) 2000-04-17
HUT71191A (en) 1995-11-28
IL109926A (en) 2000-02-29
HU217218B (hu) 1999-12-28
GR3032990T3 (en) 2000-07-31
PT629701E (pt) 2000-06-30
SG54139A1 (en) 1998-11-16

Similar Documents

Publication Publication Date Title
ES2142890T3 (es) Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13.
DE69031732D1 (de) Verfahren zur herstellung von glykosid-estern und zusammensetzungen daraus
ES2130527T3 (es) Procedimiento de hidrolisis enzimatica para la conversion de taxanos con azucar en c-7 en taxanos con hidroxilo en c-7.
ATE144287T1 (de) Verfahren zur optischen auftrennung von corey- lactondiolen
FI921122A0 (fi) Kloning och uttryckning av acetylxylanesteraser av svampursprung.
ATE5726T1 (de) Verfahren zur herstellung von antibiotikum c15003 p3.
ES534117A0 (es) Procedimiento para la obtencion de sarcosin-oxidasa
ATE147435T1 (de) Verfahren zur enzymatischen herstellung von alpha-glykosiden und deren estern
DK161339C (da) Fremgangsmaade til fremstilling af et antibiotisk kompleks, omfattende erythromycin d og estere deraf, eller dets enkelte komponenter og mikroorganismekultur til anvendelse ved fremgangsmaaden
FI894304A0 (fi) Menetelmä organismien entsyymiaktiivisuuksien ja synteesisuorituksen lisäämiseksi
ES2170841T3 (es) Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 629701

Country of ref document: ES