ES2142890T3 - Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13. - Google Patents
Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13.Info
- Publication number
- ES2142890T3 ES2142890T3 ES94108957T ES94108957T ES2142890T3 ES 2142890 T3 ES2142890 T3 ES 2142890T3 ES 94108957 T ES94108957 T ES 94108957T ES 94108957 T ES94108957 T ES 94108957T ES 2142890 T3 ES2142890 T3 ES 2142890T3
- Authority
- ES
- Spain
- Prior art keywords
- taxanes
- preparation
- groups
- enzymatic
- hydroxyl groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/365—Nocardia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2407/00—Assays, e.g. immunoassays or enzyme assays, involving terpenes
- G01N2407/02—Taxol; Taxanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
UN METODO DE HIDROLISIS ENZIMATICA, EN EL QUE UNO O MAS TAXANOS QUE CONTIENEN ACILOXI C-10 CONTACTAN CON UNA ENZIMA O MICROORGANISMO CAPAZ DE HIDROLIZAR LOS CITADOS GRUPOS DE ACILOXI A GRUPOS DE HIDROXILO. TAMBIEN SE PROPORCIONA UN METODO DE ESTERIFICACION ENZIMATICA, DONDE UNO O MAS TAXANOS QUE CONTIENEN HIDROXILO C-10 CONTACTAN CON UN AGENTE DE ACILO Y UNA ENZYMA O MICROORGANISMO CAPAZ DE ESTERIFICAR LOS CITADOS GRUPOS DE HIDROXILO, PARA FORMAR GRUPOS DE ACILOXI. ADEMAS SE PROPORCIONA UN METODO DE HIDROLISIS ENZIMATICA, DONDE UNO O MAS TAXANOS QUE CONTIENEN ACILOXI C-13 CONTACTAN CON UNA ENZYMA O MICROORGANISMO CAPAZ DE HIDROLIZAR LOS CITADOS GRUPOS DE ACILOXI A GRUPOS DE HIDROXIL. LOS METODOS SON ESPECIALMENTE UTILES PARA LA PREPARACION DE COMPUESTOS QUE PUEDEN EMPLEARSE COMO PRODUCTOS INTERMEDIOS EN LA PREPARACION DE TAXANOS TALES COMO TAXOL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/077,979 US5516676A (en) | 1993-06-15 | 1993-06-15 | Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom |
US08/077,980 US5523219A (en) | 1993-06-15 | 1993-06-15 | Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2142890T3 true ES2142890T3 (es) | 2000-05-01 |
Family
ID=26759913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94108957T Expired - Lifetime ES2142890T3 (es) | 1993-06-15 | 1994-06-10 | Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0629701B1 (es) |
JP (1) | JP3587880B2 (es) |
KR (1) | KR100342624B1 (es) |
CN (1) | CN1110565C (es) |
AT (1) | ATE189001T1 (es) |
AU (1) | AU679978B2 (es) |
CA (1) | CA2125726A1 (es) |
CY (1) | CY2205B1 (es) |
DE (1) | DE69422662T2 (es) |
DK (1) | DK0629701T3 (es) |
ES (1) | ES2142890T3 (es) |
FI (1) | FI112377B (es) |
GR (1) | GR3032990T3 (es) |
HK (1) | HK1014742A1 (es) |
HU (1) | HU217218B (es) |
IL (1) | IL109926A (es) |
PT (1) | PT629701E (es) |
SG (1) | SG54139A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
IT1275936B1 (it) * | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
SI0875508T1 (en) * | 1997-05-02 | 2004-04-30 | Pharmachemie B.V. | Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III |
US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
DE19962204A1 (de) * | 1999-12-22 | 2001-07-05 | Cognis Deutschland Gmbh | Enzym-katalysierte Modifizierung von Substanzen in biologischen Gemischen |
HUP0200750A3 (en) | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
EP1165551B1 (en) | 2000-02-02 | 2008-07-16 | Florida State University Research Foundation, Inc. | C10 carbamoyloxy substituted taxanes as antitumor agents |
KR20020002417A (ko) | 2000-02-02 | 2002-01-09 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 항종양제로서의 c7 카르바모일옥시 치환된 탁산 |
CZ20013429A3 (cs) | 2000-02-02 | 2002-04-17 | Florida State University Research Foundation, Inc. | Taxany substituované v poloze C7 karbonátem jako protinádorová činidla |
HUP0200759A3 (en) | 2000-02-02 | 2002-10-28 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
AU776765B2 (en) | 2000-02-02 | 2004-09-23 | Florida State University Research Foundation, Inc. | C7 heterosubstituted acetate taxanes as antitumor agents |
US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
DE60109165T2 (de) * | 2001-09-28 | 2006-02-16 | Council Of Scientific And Industrial Research | Verfahren zur Herstellung von 10-Desacetylbaccatin III |
US6437154B1 (en) | 2001-09-28 | 2002-08-20 | Council Of Scientific And Industrial Research | Process for the preparation of 10-deacetylbaccatin III |
HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
GT200500041A (es) | 2004-03-05 | 2005-10-24 | Taxanos con sustituyente lactiloxilo en el c7 | |
DK2080764T3 (da) | 2008-01-18 | 2012-09-24 | Indena Spa | Faste former af ortataxel |
WO2009145981A1 (en) | 2008-03-31 | 2009-12-03 | Florida State University Research Foundation, Inc. | C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes |
CN106148471A (zh) * | 2015-04-08 | 2016-11-23 | 中国科学院大连化学物理研究所 | 一种纤维单胞菌科作为工业生物催化剂的应用 |
CN105541763A (zh) * | 2016-03-03 | 2016-05-04 | 重庆市碚圣医药科技股份有限公司 | 三尖杉宁碱水解制备10-脱乙酰基巴卡丁iii的方法 |
CN107164422B (zh) * | 2016-03-08 | 2021-01-22 | 复旦大学 | 续随子二萜醇衍生物的转化方法及其在制备抗肿瘤药物中的用途 |
CN111394270B (zh) * | 2018-12-27 | 2022-04-05 | 中国农业科学院农业资源与农业区划研究所 | 一株藤黄类诺卡氏菌及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
-
1994
- 1994-06-07 IL IL10992694A patent/IL109926A/xx not_active IP Right Cessation
- 1994-06-10 DK DK94108957T patent/DK0629701T3/da active
- 1994-06-10 DE DE69422662T patent/DE69422662T2/de not_active Expired - Fee Related
- 1994-06-10 PT PT94108957T patent/PT629701E/pt unknown
- 1994-06-10 ES ES94108957T patent/ES2142890T3/es not_active Expired - Lifetime
- 1994-06-10 CN CN94106430A patent/CN1110565C/zh not_active Expired - Fee Related
- 1994-06-10 AT AT94108957T patent/ATE189001T1/de not_active IP Right Cessation
- 1994-06-10 EP EP94108957A patent/EP0629701B1/en not_active Expired - Lifetime
- 1994-06-10 SG SG1996001983A patent/SG54139A1/en unknown
- 1994-06-13 JP JP13041094A patent/JP3587880B2/ja not_active Expired - Fee Related
- 1994-06-13 FI FI942794A patent/FI112377B/fi active
- 1994-06-13 HU HU9401767A patent/HU217218B/hu not_active IP Right Cessation
- 1994-06-13 CA CA002125726A patent/CA2125726A1/en not_active Abandoned
- 1994-06-14 KR KR1019940013317A patent/KR100342624B1/ko not_active IP Right Cessation
- 1994-06-14 AU AU64671/94A patent/AU679978B2/en not_active Ceased
-
1998
- 1998-12-28 HK HK98116044A patent/HK1014742A1/xx not_active IP Right Cessation
-
2000
- 2000-03-17 GR GR20000400690T patent/GR3032990T3/el not_active IP Right Cessation
- 2000-12-19 CY CY0000060A patent/CY2205B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL109926A0 (en) | 1994-10-07 |
KR100342624B1 (ko) | 2002-11-18 |
HU9401767D0 (en) | 1994-09-28 |
HK1014742A1 (en) | 1999-09-30 |
KR950000887A (ko) | 1995-01-03 |
EP0629701A1 (en) | 1994-12-21 |
CY2205B1 (en) | 2002-11-08 |
DE69422662T2 (de) | 2000-07-20 |
ATE189001T1 (de) | 2000-02-15 |
CA2125726A1 (en) | 1994-12-16 |
DE69422662D1 (de) | 2000-02-24 |
FI942794A0 (fi) | 1994-06-13 |
AU679978B2 (en) | 1997-07-17 |
CN1110565C (zh) | 2003-06-04 |
JPH0751078A (ja) | 1995-02-28 |
EP0629701B1 (en) | 2000-01-19 |
FI942794A (fi) | 1994-12-16 |
JP3587880B2 (ja) | 2004-11-10 |
CN1101944A (zh) | 1995-04-26 |
AU6467194A (en) | 1994-12-22 |
FI112377B (fi) | 2003-11-28 |
DK0629701T3 (da) | 2000-04-17 |
HUT71191A (en) | 1995-11-28 |
IL109926A (en) | 2000-02-29 |
HU217218B (hu) | 1999-12-28 |
GR3032990T3 (en) | 2000-07-31 |
PT629701E (pt) | 2000-06-30 |
SG54139A1 (en) | 1998-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2142890T3 (es) | Procedimientos de hidrolisis enzimatica para la preparacion de taxanos con grupos hidroxilo en c-10 y c-13, procedimiento de esterificacion enzimatica para la preparacion de taxanos con grupos aciloxi en c-10 y su uso en la preparacion de taxanos con grupos aciloxi en c-13. | |
DE69031732D1 (de) | Verfahren zur herstellung von glykosid-estern und zusammensetzungen daraus | |
ES2130527T3 (es) | Procedimiento de hidrolisis enzimatica para la conversion de taxanos con azucar en c-7 en taxanos con hidroxilo en c-7. | |
ATE144287T1 (de) | Verfahren zur optischen auftrennung von corey- lactondiolen | |
FI921122A0 (fi) | Kloning och uttryckning av acetylxylanesteraser av svampursprung. | |
ATE5726T1 (de) | Verfahren zur herstellung von antibiotikum c15003 p3. | |
ES534117A0 (es) | Procedimiento para la obtencion de sarcosin-oxidasa | |
ATE147435T1 (de) | Verfahren zur enzymatischen herstellung von alpha-glykosiden und deren estern | |
DK161339C (da) | Fremgangsmaade til fremstilling af et antibiotisk kompleks, omfattende erythromycin d og estere deraf, eller dets enkelte komponenter og mikroorganismekultur til anvendelse ved fremgangsmaaden | |
FI894304A0 (fi) | Menetelmä organismien entsyymiaktiivisuuksien ja synteesisuorituksen lisäämiseksi | |
ES2170841T3 (es) | Procedimiento para la preparacion del 4,4,4-trifluoro-3(r)-hidroxi-butanoato de etilo. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 629701 Country of ref document: ES |