FI111257B - Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet Download PDF

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Publication number
FI111257B
FI111257B FI934825A FI934825A FI111257B FI 111257 B FI111257 B FI 111257B FI 934825 A FI934825 A FI 934825A FI 934825 A FI934825 A FI 934825A FI 111257 B FI111257 B FI 111257B
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FI
Finland
Prior art keywords
ylmethyl
indol
formula
compound
reaction
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FI934825A
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English (en)
Finnish (fi)
Swedish (sv)
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FI934825L (fi
FI934825A0 (fi
Inventor
John Eugene Macor
Original Assignee
Pfizer
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Publication of FI934825A0 publication Critical patent/FI934825A0/fi
Publication of FI934825L publication Critical patent/FI934825L/fi
Application granted granted Critical
Publication of FI111257B publication Critical patent/FI111257B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
FI934825A 1992-11-02 1993-11-01 Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet FI111257B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
US97075892 1992-11-02

Publications (3)

Publication Number Publication Date
FI934825A0 FI934825A0 (fi) 1993-11-01
FI934825L FI934825L (fi) 1994-05-03
FI111257B true FI111257B (fi) 2003-06-30

Family

ID=25517470

Family Applications (2)

Application Number Title Priority Date Filing Date
FI934825A FI111257B (fi) 1992-11-02 1993-11-01 Menetelmä terapeuttisesti käyttökelpoisten 5-aryyli-indolijohdannaisten valmistamiseksi sekä uudet välituoteyhdisteet
FI20002505A FI20002505L (fi) 1992-11-02 2000-11-15 5-aryyli-indolijohdannaisia

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20002505A FI20002505L (fi) 1992-11-02 2000-11-15 5-aryyli-indolijohdannaisia

Country Status (27)

Country Link
US (1) US5886008A (Direct)
EP (2) EP0666858B1 (Direct)
JP (1) JP2788551B2 (Direct)
KR (1) KR0163371B1 (Direct)
CN (1) CN1051313C (Direct)
AT (1) ATE202102T1 (Direct)
AU (1) AU685066B2 (Direct)
BR (1) BR9307348A (Direct)
CA (2) CA2148380C (Direct)
CZ (1) CZ283001B6 (Direct)
DE (1) DE69330351T2 (Direct)
DK (1) DK0666858T3 (Direct)
EG (1) EG20396A (Direct)
ES (1) ES2157224T3 (Direct)
FI (2) FI111257B (Direct)
GR (1) GR3036579T3 (Direct)
HU (1) HU222235B1 (Direct)
IL (1) IL107386A (Direct)
MY (1) MY109696A (Direct)
NO (1) NO309652B1 (Direct)
NZ (1) NZ257059A (Direct)
PL (1) PL176091B1 (Direct)
PT (1) PT666858E (Direct)
RU (1) RU2134266C1 (Direct)
TW (1) TW251284B (Direct)
WO (1) WO1994010171A1 (Direct)
ZA (1) ZA938137B (Direct)

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US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
CA2501365C (en) 2002-10-30 2011-05-31 Merck & Co., Inc. Inhibitors of akt activity
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
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DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
BRPI0413740A (pt) * 2003-08-21 2006-10-24 Osi Pharm Inc composto ou um seu n-óxido ou seu sal farmaceuticamente aceitável, composição, e, método de tratamento de distúrbio hiperproliferativo
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
KR101130928B1 (ko) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
ES2346157T3 (es) * 2006-03-22 2010-10-11 Janssen Pharmaceutica N.V. Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53.
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
CA2984305C (en) 2015-04-29 2021-12-28 Janssen Pharmaceutica Nv Indolone compounds and their use as ampa receptor modulators
US11312712B2 (en) * 2015-04-29 2022-04-26 Janssen Pharmaceutica Nv Azabenzimidazoles and their use as AMPA receptor modulators
KR20170141767A (ko) 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도
US10513523B2 (en) 2015-04-29 2019-12-24 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
EP3371170B1 (en) 2015-11-06 2019-07-31 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
JP6839184B2 (ja) 2015-11-06 2021-03-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ インドリン−２−オン誘導体
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Also Published As

Publication number Publication date
CA2340999A1 (en) 1994-05-11
IL107386A (en) 1999-03-12
US5886008A (en) 1999-03-23
ATE202102T1 (de) 2001-06-15
JP2788551B2 (ja) 1998-08-20
CN1051313C (zh) 2000-04-12
CA2148380A1 (en) 1994-05-11
FI20002505A7 (fi) 2000-11-15
CN1094727A (zh) 1994-11-09
KR0163371B1 (ko) 1998-12-01
PT666858E (pt) 2001-09-28
AU5329494A (en) 1994-05-24
BR9307348A (pt) 1999-05-11
ZA938137B (en) 1995-05-02
TW251284B (Direct) 1995-07-11
KR950704313A (ko) 1995-11-17
DK0666858T3 (da) 2001-08-27
CA2340999C (en) 2005-01-04
CZ110895A3 (en) 1995-11-15
RU95109927A (ru) 1997-01-10
NO951633L (no) 1995-04-28
JPH07508759A (ja) 1995-09-28
HUT66011A (en) 1994-08-29
CA2148380C (en) 2001-08-14
HU222235B1 (hu) 2003-05-28
EP0666858B1 (en) 2001-06-13
IL107386A0 (en) 1994-01-25
AU685066B2 (en) 1998-01-15
NZ257059A (en) 1997-07-27
MY109696A (en) 1997-04-30
EG20396A (en) 1999-02-28
DE69330351D1 (de) 2001-07-19
FI934825L (fi) 1994-05-03
EP0666858A1 (en) 1995-08-16
WO1994010171A1 (en) 1994-05-11
FI20002505L (fi) 2000-11-15
DE69330351T2 (de) 2001-09-20
PL308669A1 (en) 1995-08-21
CZ283001B6 (cs) 1997-12-17
ES2157224T3 (es) 2001-08-16
RU2134266C1 (ru) 1999-08-10
FI934825A0 (fi) 1993-11-01
NO951633D0 (no) 1995-04-28
NO309652B1 (no) 2001-03-05
EP1094064A1 (en) 2001-04-25
PL176091B1 (pl) 1999-04-30
GR3036579T3 (en) 2001-12-31

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