FI109810B - Menetelmä rekombinanttiproteiinien entsymaattiseksi pilkkomiseksi käyttämällä IgA-proteaaseja - Google Patents

Menetelmä rekombinanttiproteiinien entsymaattiseksi pilkkomiseksi käyttämällä IgA-proteaaseja Download PDF

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Publication number
FI109810B
FI109810B FI923463A FI923463A FI109810B FI 109810 B FI109810 B FI 109810B FI 923463 A FI923463 A FI 923463A FI 923463 A FI923463 A FI 923463A FI 109810 B FI109810 B FI 109810B
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Finland
Prior art keywords
pro
protein
amino acid
proteins
fused
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FI923463A
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English (en)
Finnish (fi)
Swedish (sv)
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FI923463A (fi
FI923463A0 (fi
Inventor
Thomas F Meyer
Johannes Pohlner
Carola Dony
Guenter Schumacher
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Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4015922A external-priority patent/DE4015922A1/de
Priority claimed from DE4039415A external-priority patent/DE4039415A1/de
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of FI923463A publication Critical patent/FI923463A/fi
Publication of FI923463A0 publication Critical patent/FI923463A0/fi
Application granted granted Critical
Publication of FI109810B publication Critical patent/FI109810B/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5403IL-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5409IL-5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI923463A 1990-02-03 1992-07-31 Menetelmä rekombinanttiproteiinien entsymaattiseksi pilkkomiseksi käyttämällä IgA-proteaaseja FI109810B (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE4003149 1990-02-03
DE4003149 1990-02-03
DE4015922A DE4015922A1 (de) 1990-05-17 1990-05-17 Verfahren zur enzymatischen prozessierung von proteinen unter verwendung von iga-proteasen (igase)
DE4015922 1990-05-17
DE4015921 1990-05-17
DE4015921 1990-05-17
DE4039415 1990-12-10
DE4039415A DE4039415A1 (de) 1990-02-03 1990-12-10 Verfahren zur herstellung rekombinanter proteine ohne n-terminalen methioninrest
PCT/EP1991/000192 WO1991011520A1 (fr) 1990-02-03 1991-02-01 PROCEDE DE CLIVAGE ENZYMATIQUE DE PROTEINES RECOMBINANTES AU MOYEN DE PROTEASES D'IgA
EP9100192 1991-02-01

Publications (3)

Publication Number Publication Date
FI923463A FI923463A (fi) 1992-07-31
FI923463A0 FI923463A0 (fi) 1992-07-31
FI109810B true FI109810B (fi) 2002-10-15

Family

ID=27434868

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923463A FI109810B (fi) 1990-02-03 1992-07-31 Menetelmä rekombinanttiproteiinien entsymaattiseksi pilkkomiseksi käyttämällä IgA-proteaaseja

Country Status (19)

Country Link
US (1) US5427927A (fr)
EP (2) EP0602688B1 (fr)
JP (2) JPH0789952B2 (fr)
KR (1) KR960011919B1 (fr)
AT (2) ATE219518T1 (fr)
AU (1) AU638309B2 (fr)
CA (1) CA2074943C (fr)
CZ (1) CZ284774B6 (fr)
DK (1) DK0513073T3 (fr)
ES (2) ES2177536T3 (fr)
FI (1) FI109810B (fr)
HU (1) HU217103B (fr)
IE (1) IE64938B1 (fr)
IL (1) IL97119A0 (fr)
LV (1) LV10309B (fr)
NO (1) NO311142B1 (fr)
NZ (1) NZ236819A (fr)
PT (1) PT96658B (fr)
WO (1) WO1991011520A1 (fr)

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US20030190740A1 (en) * 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
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KR100356140B1 (ko) * 1999-07-08 2002-10-19 한미약품공업 주식회사 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법
US7668658B2 (en) * 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
JP4786904B2 (ja) * 2002-11-27 2011-10-05 セクエノム,インコーポレイティド 配列変化検出及び発見用の断片化をベースとする方法及びシステム
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US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
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UA95446C2 (ru) 2005-05-04 2011-08-10 Іллюміджен Байосайєнсіз, Інк. Мутаци в генах oas1
BRPI0715754A2 (pt) 2006-08-31 2013-07-09 Hoffmann La Roche mÉtodo para a produÇço de fator do crescimento similar Á insulina i
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Also Published As

Publication number Publication date
NZ236819A (en) 1993-07-27
CA2074943A1 (fr) 1991-08-04
JPH0789952B2 (ja) 1995-10-04
PT96658B (pt) 1998-09-30
FI923463A (fi) 1992-07-31
HU217103B (hu) 1999-11-29
CA2074943C (fr) 1999-12-07
EP0602688A1 (fr) 1994-06-22
AU7149691A (en) 1991-08-21
DK0513073T3 (da) 1995-10-30
FI923463A0 (fi) 1992-07-31
PT96658A (pt) 1991-10-31
ES2177536T3 (es) 2002-12-16
KR960011919B1 (ko) 1996-09-04
CZ284774B6 (cs) 1999-02-17
ES2076521T3 (es) 1995-11-01
NO923010L (no) 1992-09-14
ATE124456T1 (de) 1995-07-15
HU9202511D0 (en) 1992-10-28
JP2766621B2 (ja) 1998-06-18
EP0513073A1 (fr) 1992-11-19
JPH07278195A (ja) 1995-10-24
IE910358A1 (en) 1991-08-14
IL97119A0 (en) 1992-03-29
EP0602688B1 (fr) 2002-06-19
EP0513073B1 (fr) 1995-06-28
US5427927A (en) 1995-06-27
LV10309A (lv) 1994-10-20
LV10309B (en) 1995-12-20
NO923010D0 (no) 1992-07-30
JPH05501360A (ja) 1993-03-18
WO1991011520A1 (fr) 1991-08-08
NO311142B1 (no) 2001-10-15
CS9100241A2 (en) 1991-08-13
IE64938B1 (en) 1995-09-20
ATE219518T1 (de) 2002-07-15
AU638309B2 (en) 1993-06-24
HUT63195A (en) 1993-07-28

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