FI106379B - Menetelmä valmistaa ihmisen valkosoluelastaasi-inhibiittorina käytettäviä trifluorimetyyliketonijohdoksia - Google Patents
Menetelmä valmistaa ihmisen valkosoluelastaasi-inhibiittorina käytettäviä trifluorimetyyliketonijohdoksia Download PDFInfo
- Publication number
- FI106379B FI106379B FI915996A FI915996A FI106379B FI 106379 B FI106379 B FI 106379B FI 915996 A FI915996 A FI 915996A FI 915996 A FI915996 A FI 915996A FI 106379 B FI106379 B FI 106379B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- valyl
- formula
- amino
- trifluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Hydrogenated Pyridines (AREA)
- Magnetically Actuated Valves (AREA)
- Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9028231 | 1990-12-31 | ||
GB909028231A GB9028231D0 (en) | 1990-12-31 | 1990-12-31 | Trifluoromethylketone derivatives,processes for preparation thereof and use thereof |
GB919119713A GB9119713D0 (en) | 1991-09-16 | 1991-09-16 | Trifluoremethylketone derivatives, processes for preparation thereof and use thereof |
GB9119713 | 1991-09-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI915996A0 FI915996A0 (fi) | 1991-12-19 |
FI915996A FI915996A (fi) | 1992-07-01 |
FI106379B true FI106379B (fi) | 2001-01-31 |
Family
ID=26298196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI915996A FI106379B (fi) | 1990-12-31 | 1991-12-19 | Menetelmä valmistaa ihmisen valkosoluelastaasi-inhibiittorina käytettäviä trifluorimetyyliketonijohdoksia |
Country Status (19)
Country | Link |
---|---|
US (2) | US5296591A (hu) |
EP (1) | EP0494071B1 (hu) |
JP (1) | JPH0699378B2 (hu) |
KR (1) | KR100192991B1 (hu) |
CN (1) | CN1040003C (hu) |
AT (1) | ATE151775T1 (hu) |
AU (1) | AU641577B2 (hu) |
CA (1) | CA2058560C (hu) |
DE (1) | DE69218977T2 (hu) |
DK (1) | DK0494071T3 (hu) |
ES (1) | ES2099755T3 (hu) |
FI (1) | FI106379B (hu) |
GR (1) | GR3023719T3 (hu) |
HU (2) | HU210263B (hu) |
IE (1) | IE914360A1 (hu) |
MX (1) | MX9102612A (hu) |
NO (1) | NO309274B1 (hu) |
RU (1) | RU2073684C1 (hu) |
SG (1) | SG50457A1 (hu) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296591A (en) * | 1990-12-31 | 1994-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Trifluoromethylketone derivatives, processes for preparation thereof and use thereof |
US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
US5714470A (en) | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
FR2694295B1 (fr) * | 1992-07-28 | 1994-09-02 | Adir | Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent. |
FR2719589B1 (fr) * | 1994-05-05 | 1996-06-14 | Adir | Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
CN1152048C (zh) * | 1994-06-02 | 2004-06-02 | 默里尔药物公司 | 弹性蛋白酶的全氟烷基酮抑制剂及其制备方法 |
ES2161293T3 (es) * | 1994-06-02 | 2001-12-01 | Merrell Pharma Inc | Derivados de enol acilados como profarmacos de inhibidores de la elastasa. |
US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
JP2002161051A (ja) * | 1996-12-24 | 2002-06-04 | Fujisawa Pharmaceut Co Ltd | 脳虚血性疾患等の治療剤 |
US6610748B1 (en) * | 1998-02-24 | 2003-08-26 | Fujisawa Pharmaceutical Co., Ltd. | Preventives/remedies for skin aging |
US20020045231A1 (en) * | 1999-02-02 | 2002-04-18 | Napper Andrew D. | Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies |
WO2001026685A1 (fr) * | 1999-10-12 | 2001-04-19 | Fujisawa Pharmaceutical Co., Ltd. | Remedes pour plaies chroniques |
IL148924A (en) * | 2002-03-26 | 2015-06-30 | Mor Research Applic Ltd | Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases |
DE10219464A1 (de) | 2002-04-30 | 2003-11-13 | Focke & Co | Zigarettenpackung |
SE0202462D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel use |
CA2651043A1 (en) * | 2006-05-23 | 2007-12-06 | David C. Tully | Compounds and compositions as channel activating protease inhibitors |
JP4101276B2 (ja) * | 2006-08-25 | 2008-06-18 | 株式会社ステリック再生医科学研究所 | 慢性閉塞性肺疾患改善剤 |
EP2099454A4 (en) * | 2006-11-17 | 2010-11-10 | Abbott Lab | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS |
CN102656141B (zh) | 2009-10-13 | 2016-04-06 | 利亘制药公司 | 模拟造血生长因子的小分子化合物及其用途 |
MX362192B (es) * | 2013-05-08 | 2019-01-08 | Kissei Pharmaceutical | Derivado de glicinamida alfa-sustituida. |
CN104650016A (zh) * | 2015-01-29 | 2015-05-27 | 武汉大学 | 拟三肽类化合物及其制备方法 |
ES2905761T3 (es) * | 2016-06-24 | 2022-04-12 | Pola Chem Ind Inc | Preparación externa para la piel para la mejora de las arrugas |
IL274690B2 (en) | 2017-11-15 | 2023-12-01 | Pola Chem Ind Inc | An oil-based preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
EP0276101A3 (en) * | 1987-01-19 | 1989-11-23 | Ici Americas Inc. | Substituted peptide derivatives |
EP0369391A3 (en) | 1988-11-15 | 1991-09-25 | Boehringer Ingelheim Pharmaceuticals Inc. | N-substituted amides |
US5221665A (en) * | 1989-10-27 | 1993-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | N-substituted amides |
US5296591A (en) * | 1990-12-31 | 1994-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Trifluoromethylketone derivatives, processes for preparation thereof and use thereof |
-
1991
- 1991-12-12 US US07/805,610 patent/US5296591A/en not_active Expired - Lifetime
- 1991-12-13 IE IE436091A patent/IE914360A1/en unknown
- 1991-12-17 MX MX9102612A patent/MX9102612A/es unknown
- 1991-12-19 JP JP3361134A patent/JPH0699378B2/ja not_active Expired - Lifetime
- 1991-12-19 FI FI915996A patent/FI106379B/fi active
- 1991-12-19 AU AU89853/91A patent/AU641577B2/en not_active Expired
- 1991-12-27 KR KR1019910024710A patent/KR100192991B1/ko not_active IP Right Cessation
- 1991-12-28 RU SU5010583/04A patent/RU2073684C1/ru active
- 1991-12-30 HU HU914153A patent/HU210263B/hu unknown
- 1991-12-30 CA CA002058560A patent/CA2058560C/en not_active Expired - Lifetime
- 1991-12-30 CN CN91112615A patent/CN1040003C/zh not_active Expired - Lifetime
-
1992
- 1992-01-02 ES ES92100014T patent/ES2099755T3/es not_active Expired - Lifetime
- 1992-01-02 SG SG1996001866A patent/SG50457A1/en unknown
- 1992-01-02 DE DE69218977T patent/DE69218977T2/de not_active Expired - Lifetime
- 1992-01-02 DK DK92100014.7T patent/DK0494071T3/da active
- 1992-01-02 AT AT92100014T patent/ATE151775T1/de not_active IP Right Cessation
- 1992-01-02 EP EP92100014A patent/EP0494071B1/en not_active Expired - Lifetime
- 1992-01-02 NO NO19920035A patent/NO309274B1/no not_active IP Right Cessation
-
1993
- 1993-11-30 US US08/158,981 patent/US5430025A/en not_active Expired - Lifetime
-
1995
- 1995-06-22 HU HU95P/P00355P patent/HU211943A9/hu unknown
-
1997
- 1997-06-10 GR GR970401361T patent/GR3023719T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR100192991B1 (ko) | 1999-06-15 |
NO920035L (no) | 1992-07-01 |
HU211943A9 (en) | 1996-01-29 |
DK0494071T3 (hu) | 1997-05-12 |
KR920011988A (ko) | 1992-07-25 |
DE69218977T2 (de) | 1997-08-07 |
FI915996A0 (fi) | 1991-12-19 |
JPH04297446A (ja) | 1992-10-21 |
HU210263B (en) | 1995-03-28 |
IE914360A1 (en) | 1992-07-01 |
DE69218977D1 (de) | 1997-05-22 |
JPH0699378B2 (ja) | 1994-12-07 |
CN1040003C (zh) | 1998-09-30 |
FI915996A (fi) | 1992-07-01 |
EP0494071B1 (en) | 1997-04-16 |
NO309274B1 (no) | 2001-01-08 |
CA2058560C (en) | 2000-12-12 |
EP0494071A3 (en) | 1993-05-05 |
US5296591A (en) | 1994-03-22 |
EP0494071A2 (en) | 1992-07-08 |
ATE151775T1 (de) | 1997-05-15 |
GR3023719T3 (en) | 1997-09-30 |
HU914153D0 (en) | 1992-03-30 |
CA2058560A1 (en) | 1992-07-01 |
CN1063108A (zh) | 1992-07-29 |
AU8985391A (en) | 1992-07-02 |
SG50457A1 (en) | 1998-07-20 |
NO920035D0 (no) | 1992-01-02 |
RU2073684C1 (ru) | 1997-02-20 |
AU641577B2 (en) | 1993-09-23 |
ES2099755T3 (es) | 1997-06-01 |
US5430025A (en) | 1995-07-04 |
MX9102612A (es) | 1992-06-01 |
HUT60507A (en) | 1992-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI106379B (fi) | Menetelmä valmistaa ihmisen valkosoluelastaasi-inhibiittorina käytettäviä trifluorimetyyliketonijohdoksia | |
US5254558A (en) | Substituted 1,3-diazines as leukocyte elastase inhibitors | |
JP5558710B2 (ja) | Hdac阻害剤としてのfk228誘導体 | |
RU2266901C2 (ru) | 4-пиримидинил-n-ацил-l-фенилаланины и фармацевтическая композиция | |
EP0822931B1 (en) | Piperazinones useful as inhibitors of platelet aggregation | |
JPH0437070B2 (hu) | ||
RU2270193C2 (ru) | 4-пиридинил-n-ацил-l-фенилаланины | |
WO1995000535A1 (en) | Optically pure calpain inhibitor compounds | |
JP2002535394A (ja) | トリプターゼインヒビターとして有用なペプチジル複素環式ケトン | |
SK280292A3 (en) | New derivatives of 5-amino-4-hydroxyhexane acid effecting as therapeutic agents | |
JPH02279661A (ja) | アミノ酸誘導体 | |
ES2228472T3 (es) | Derivados de beta-alanina. | |
AU709088B2 (en) | Thrombin inhibitors | |
IE45095B1 (en) | Dipeptide derivatives | |
US6417161B1 (en) | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors | |
CA2043603A1 (en) | Hiv protease inhibitors and processes for their preparation | |
FR2540866A1 (fr) | Acides aminocetone carboxyliques utilisables comme intermediaires pour la preparation de peptides substitues | |
JPS595150A (ja) | 抗微生物性ジスルフイドプロドラツグ | |
EP0055846B1 (en) | New peptide, process for preparation thereof and pharmaceutical composition containing it | |
EP2054402B1 (en) | An aminoisoquinoline thrombin inhibitor with improved bioavailability | |
JP2017518290A (ja) | β−アレスチンエフェクターの合成 | |
AU658426B2 (en) | Substituted heterocycles | |
JPH07316056A (ja) | エラスターゼ阻害用医薬組成物 | |
JPH029863A (ja) | トリ置換−1,2,3,4−テトラヒドロイソキノリン | |
JP2001518466A (ja) | トロンビン阻害薬 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: ASTELLAS PHARMA INC. Free format text: ASTELLAS PHARMA INC. |