FI104539B - Förfarande för att producera en modifierad grupp B polysacharid av Neisseria meningitidis eller en modifierad E. coli K1-kapsulär polysackarid - Google Patents
Förfarande för att producera en modifierad grupp B polysacharid av Neisseria meningitidis eller en modifierad E. coli K1-kapsulär polysackarid Download PDFInfo
- Publication number
- FI104539B FI104539B FI922737A FI922737A FI104539B FI 104539 B FI104539 B FI 104539B FI 922737 A FI922737 A FI 922737A FI 922737 A FI922737 A FI 922737A FI 104539 B FI104539 B FI 104539B
- Authority
- FI
- Finland
- Prior art keywords
- gbmp
- polysaccharide
- group
- butanoyl
- protein
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Claims (13)
1. Förfarande för att producera en modifierad grupp B polysackarid av Neisseria 10 meningitidis eller en modifierad E. coli Kl-kapsulär polysackarid, kännetecknat av att N-acetylgruppema i sialinsyraresten i den nativa polysackariden ersätts med C4-Cg-acylgrupper och den modifierade polysackariden har en medelmolekylvikt inom omrädet 10 000 tili 50 000 Dalton.
2. Förfarande enligt patentkrav 1, kännetecknat av att C4-C8-acylgruppen är vald 15 ur den grupp som bestär av n-butanoyl, iso-butanoyl, n-pentanoyl, n-hexanoyl, n- heptanoyl och n-oktanoyl.
3. Förfarande enligt patentkrav 2, kännetecknat av att acylgruppen är vald ur den grupp som bestär av n-butanoyl, iso-butanoyl, n-pentanoyl och n-hexanoyl.
4. Förfarande enligt patentkrav 2, kännetecknat av att acylgruppen är n-butano- . 20 yl.
5. Förfarande enligt patentkrav 1, kännetecknat av att ca 27-100 % av N-acetyl-gruppema i sialinsyraresten har ersatts med C4-C8-acylgrupper.
6. Förfarande enligt patentkrav 5, kännetecknat av att ca 90-100 % av N-acetylgruppema i sialinsyraresten har ersatts med C4-C8-acylgrupper. ·> 25
7. Förfarande för att producera ett antigent konjugat, kännetecknat av att en : modifierad grupp B polysackarid av Neisseria meningitidis, vars N-acetylgrupp i sialinsyraresten är ersatt med en N-C4-C8-acylgrupp, konjugeras tili ett immunolo-giskt lämpligt protein. 104539
8. Förfarande enligt patentkrav 7, kännetecknat av att acylgruppen är vald ur den grupp som bestär av n-butanoyl, iso-butanoyl, pentanoyl, hexanoyl, heptanoyl och oktanoyl. r
9. Förfarande enligt patentkrav 7, kännetecknat av att acylgruppen är vald ur 5 den grupp som bestär av n-butanoyl, iso-butanoyl, pentanoyl och hexanoyl.
10. Förfarande enligt patentkrav 6, kännetecknat av att acylgruppen är n-butanoyl·
11. Förfarande enligt patentkrav 7, kännetecknat av att proteinet är valt ur den grupp som bestär av tetanustoxoid, difteritoxoid, ett korsreagerande material (CRM) 10 och en bakteriell proteinbärare.
12. Förfarande enligt patentkrav 7, kännetecknat av att proteinet och polysackari-den är kovalent kopplade genom en -CH2-NH-protein-koppling.
13. Förfarande enligt patentkrav 11, kännetecknat av att CRM är CRMi97. • ♦ « t ?
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44819589A | 1989-12-14 | 1989-12-14 | |
| US44819589 | 1989-12-14 | ||
| PCT/CA1990/000437 WO1991008772A1 (en) | 1989-12-14 | 1990-12-13 | Improved meningococcal polysaccharide conjugate vaccine |
| CA9000437 | 1990-12-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI922737A0 FI922737A0 (fi) | 1992-06-12 |
| FI104539B true FI104539B (sv) | 2000-02-29 |
Family
ID=23779371
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI922737A FI104539B (sv) | 1989-12-14 | 1992-06-12 | Förfarande för att producera en modifierad grupp B polysacharid av Neisseria meningitidis eller en modifierad E. coli K1-kapsulär polysackarid |
| FI991917A FI19991917A (sv) | 1989-12-14 | 1999-09-09 | Förbättrat meningokock-polysackaridkonjugatvaccin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI991917A FI19991917A (sv) | 1989-12-14 | 1999-09-09 | Förbättrat meningokock-polysackaridkonjugatvaccin |
Country Status (30)
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| JP (1) | JP2637845B2 (sv) |
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| CN (4) | CN1049223C (sv) |
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| AT (1) | ATE121947T1 (sv) |
| AU (1) | AU641715B2 (sv) |
| BR (1) | BR9007917A (sv) |
| CA (1) | CA2071811C (sv) |
| CZ (1) | CZ283530B6 (sv) |
| DE (1) | DE69019164T2 (sv) |
| DK (1) | DK0504202T3 (sv) |
| ES (1) | ES2071288T3 (sv) |
| FI (2) | FI104539B (sv) |
| HR (1) | HRP920872A2 (sv) |
| HU (2) | HU218146B (sv) |
| IE (1) | IE68414B1 (sv) |
| IL (1) | IL96676A (sv) |
| IN (1) | IN171747B (sv) |
| NO (2) | NO305275B1 (sv) |
| NZ (1) | NZ236471A (sv) |
| PH (1) | PH30305A (sv) |
| PL (2) | PL166035B1 (sv) |
| RO (1) | RO111416B1 (sv) |
| RU (1) | RU2105568C1 (sv) |
| SI (1) | SI20008B (sv) |
| WO (1) | WO1991008772A1 (sv) |
| YU (1) | YU24391A (sv) |
| ZA (1) | ZA9010065B (sv) |
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| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
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| US6284884B1 (en) | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
| ZA97248B (en) * | 1996-01-18 | 1997-07-18 | Rohm & Haas | Method for identifying and quantifying polymers utilizing immunoassay techniques |
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| US6518037B2 (en) * | 1999-11-12 | 2003-02-11 | University Of Iowa Research Foundation | Two-component system that controls bacterial membrane synthesis |
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-
1990
- 1990-12-13 DK DK91900142.0T patent/DK0504202T3/da active
- 1990-12-13 RO RO92-0789A patent/RO111416B1/ro unknown
- 1990-12-13 AU AU68987/91A patent/AU641715B2/en not_active Ceased
- 1990-12-13 HU HU9201966A patent/HU218146B/hu unknown
- 1990-12-13 ES ES91900142T patent/ES2071288T3/es not_active Expired - Lifetime
- 1990-12-13 AT AT91900142T patent/ATE121947T1/de not_active IP Right Cessation
- 1990-12-13 EP EP91900142A patent/EP0504202B1/en not_active Expired - Lifetime
- 1990-12-13 KR KR1019920701403A patent/KR0158436B1/ko not_active IP Right Cessation
- 1990-12-13 DE DE69019164T patent/DE69019164T2/de not_active Expired - Fee Related
- 1990-12-13 CA CA002071811A patent/CA2071811C/en not_active Expired - Fee Related
- 1990-12-13 RU SU5052391A patent/RU2105568C1/ru active
- 1990-12-13 JP JP3500908A patent/JP2637845B2/ja not_active Expired - Fee Related
- 1990-12-13 BR BR909007917A patent/BR9007917A/pt not_active Application Discontinuation
- 1990-12-13 HU HU9201966A patent/HU9201966D0/hu unknown
- 1990-12-13 WO PCT/CA1990/000437 patent/WO1991008772A1/en active IP Right Grant
- 1990-12-14 IE IE451390A patent/IE68414B1/en not_active IP Right Cessation
- 1990-12-14 SI SI9110243A patent/SI20008B/sl not_active IP Right Cessation
- 1990-12-14 AR AR90318627A patent/AR243934A1/es active
- 1990-12-14 ZA ZA9010065A patent/ZA9010065B/xx unknown
- 1990-12-14 IL IL9667690A patent/IL96676A/en not_active IP Right Cessation
- 1990-12-14 IN IN1033/CAL/90A patent/IN171747B/en unknown
- 1990-12-14 NZ NZ236471A patent/NZ236471A/en unknown
- 1990-12-14 CZ CS906284A patent/CZ283530B6/cs unknown
- 1990-12-14 PL PL90288271A patent/PL166035B1/pl not_active IP Right Cessation
- 1990-12-14 PL PL90302476A patent/PL166659B1/pl not_active IP Right Cessation
- 1990-12-14 CN CN90110444A patent/CN1049223C/zh not_active Expired - Fee Related
- 1990-12-14 YU YU24391A patent/YU24391A/sh unknown
- 1990-12-14 PH PH41724A patent/PH30305A/en unknown
-
1992
- 1992-06-12 FI FI922737A patent/FI104539B/sv active
- 1992-06-12 NO NO922316A patent/NO305275B1/no unknown
- 1992-10-02 HR HRP-243/91A patent/HRP920872A2/hr not_active Application Discontinuation
-
1993
- 1993-11-22 CN CN93119467A patent/CN1036504C/zh not_active Expired - Fee Related
- 1993-11-22 CN CN93114764A patent/CN1072506C/zh not_active Expired - Fee Related
- 1993-11-22 CN CN93114763A patent/CN1036522C/zh not_active Expired - Fee Related
-
1994
- 1994-05-05 US US08/238,600 patent/US5576002A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/485,623 patent/US5683699A/en not_active Expired - Lifetime
-
1997
- 1997-07-17 NO NO973311A patent/NO307835B1/no unknown
- 1997-10-17 US US08/953,771 patent/US5902586A/en not_active Expired - Fee Related
-
1999
- 1999-09-09 FI FI991917A patent/FI19991917A/sv unknown
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