ES8707238A1 - Procedimiento para preparar pteridinas - Google Patents

Procedimiento para preparar pteridinas

Info

Publication number
ES8707238A1
ES8707238A1 ES549806A ES549806A ES8707238A1 ES 8707238 A1 ES8707238 A1 ES 8707238A1 ES 549806 A ES549806 A ES 549806A ES 549806 A ES549806 A ES 549806A ES 8707238 A1 ES8707238 A1 ES 8707238A1
Authority
ES
Spain
Prior art keywords
group
denotes
pteridines
piperazino
alkylphenylalkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549806A
Other languages
English (en)
Other versions
ES549806A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8707238A1 publication Critical patent/ES8707238A1/es
Publication of ES549806A0 publication Critical patent/ES549806A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PTERIDINAS, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDOS. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN EXCESO DE UNA AMINA DE FORMULA H-X, PARA OBTENER UN COMPUESTO DE FORMULA (I) EN LAS QUE X, Z2, Z7, R2, R4, R6 Y R7 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES TROMBO-EMBOLICAS, ARTERIOESCLEROSIS, METASTASIS Y PARA INHIBIR EL CRECIMIENTO DE TUMORES.
ES549806A 1984-12-12 1985-12-11 Procedimiento para preparar pteridinas Expired ES8707238A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843445298 DE3445298A1 (de) 1984-12-12 1984-12-12 Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel

Publications (2)

Publication Number Publication Date
ES8707238A1 true ES8707238A1 (es) 1987-07-16
ES549806A0 ES549806A0 (es) 1987-07-16

Family

ID=6252576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549806A Expired ES8707238A1 (es) 1984-12-12 1985-12-11 Procedimiento para preparar pteridinas

Country Status (15)

Country Link
EP (1) EP0185259A3 (es)
JP (1) JPS61140585A (es)
AU (1) AU576924B2 (es)
CA (1) CA1252783A (es)
DE (1) DE3445298A1 (es)
DK (1) DK161327C (es)
ES (1) ES8707238A1 (es)
FI (1) FI82696C (es)
GR (1) GR852996B (es)
IL (1) IL77294A (es)
NO (1) NO161373C (es)
NZ (1) NZ214522A (es)
PH (1) PH24451A (es)
PT (1) PT81650B (es)
ZA (1) ZA859462B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
IL159540A0 (en) * 2001-06-28 2004-06-01 Pliva D D Heterocyclic compounds as selective bacterial dhfr inhibitors and the uses thereof
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
ES2295897T3 (es) * 2003-08-29 2008-04-16 4 Aza Ip Nv Efectos inmunodepresores de derivados de pteridina.
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
PL1673092T3 (pl) * 2003-10-17 2008-01-31 4 Aza Ip Nv Pochodne pterydyny podstawione heterocyklem i ich zastosowanie w leczeniu
CN1950081A (zh) * 2004-03-04 2007-04-18 神经能质公司 芳烷氨基取代的喹唑啉类似物
DE102004057618A1 (de) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057594A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
RU2445315C2 (ru) * 2005-11-22 2012-03-20 Кудос Фармасьютиклз Лимитед ПРОИЗВОДНЫЕ ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
JP5161102B2 (ja) * 2005-11-22 2013-03-13 クドス ファーマシューティカルズ リミテッド ｍＴＯＲ阻害剤としてのピリドピリミジン、ピラゾピリミジンおよびピリミドピリミジン誘導体
WO2007135026A2 (de) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituierte pteridine als therapeutika
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
JP5227321B2 (ja) 2006-08-23 2013-07-03 クドス ファーマシューティカルズ リミテッド Ｍｔｏｒ阻害剤としての２−メチルモルホリンピリド−、ピラゾ−及びピリミド−ピリミジン誘導体
WO2009153597A2 (en) 2008-06-20 2009-12-23 Astrazeneca Ab Composition and process - 356
SI3097102T1 (en) 2015-03-04 2018-02-28 Gilead Sciences, Inc. A TOOL RECEPTOR MODULING 4,6-DIAMINO-PYRIDO (3,2-D) PYRIMIDINE COMPOUNDS
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159628A (en) * 1962-05-28 1964-12-01 Smith Kline French Lab Pteridine-5-oxide derivatives
DE3323932A1 (de) * 1983-07-02 1985-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Also Published As

Publication number Publication date
FI854862A (fi) 1986-06-13
ZA859462B (en) 1987-07-29
NO161373C (no) 1989-08-09
DK572685A (da) 1986-06-13
FI82696C (fi) 1991-04-10
FI82696B (fi) 1990-12-31
JPS61140585A (ja) 1986-06-27
EP0185259A3 (de) 1989-03-01
GR852996B (es) 1986-04-16
CA1252783A (en) 1989-04-18
AU5123285A (en) 1986-06-19
NO161373B (no) 1989-05-02
DK572685D0 (da) 1985-12-11
AU576924B2 (en) 1988-09-08
DE3445298A1 (de) 1986-06-12
NO854965L (no) 1986-06-13
DK161327B (da) 1991-06-24
PT81650A (de) 1986-01-01
EP0185259A2 (de) 1986-06-25
PT81650B (pt) 1988-04-21
DK161327C (da) 1991-12-09
NZ214522A (en) 1988-07-28
ES549806A0 (es) 1987-07-16
FI854862A0 (fi) 1985-12-10
IL77294A (en) 1989-02-28
PH24451A (en) 1990-06-25

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506