ES8301239A1 - Procedimiento para la preparacion de nitratos de alquilami- nodesoxi-1.4,3.6-dianhidro-hexito sustituidos con bases pu- rinicas - Google Patents

Procedimiento para la preparacion de nitratos de alquilami- nodesoxi-1.4,3.6-dianhidro-hexito sustituidos con bases pu- rinicas

Info

Publication number
ES8301239A1
ES8301239A1 ES503485A ES503485A ES8301239A1 ES 8301239 A1 ES8301239 A1 ES 8301239A1 ES 503485 A ES503485 A ES 503485A ES 503485 A ES503485 A ES 503485A ES 8301239 A1 ES8301239 A1 ES 8301239A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
group
purine bases
hexite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503485A
Other languages
English (en)
Other versions
ES503485A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of ES503485A0 publication Critical patent/ES503485A0/es
Publication of ES8301239A1 publication Critical patent/ES8301239A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NITRATOS DE ALQUILAMINO-DESOXI-1.4;3.6-DIANHIDRO-HEXITO SUSTITUIDOS CON BASES PURINICAS. PARA OBTENER COMPUESTOS DE FORMULA (I) DONDE R ES HIDROGENO O UN GRUPO ALQUILO INFERIOR DE C -C , X ES UN GRUPO ALQUILO O HIDROXIALQUILO DE C -C E Y ES UN GRUPO 1.3-DIALQUILXANTIN-7-ILO O UN GRUPO 3.7-DIALQUILXANTIN-1-ILO, CADA UNO CON GRUPOS ALQUILO DE C -C , O UN GRUPO ADENIN-9-ILO, ASI COMO SUS SALES DE ADICION ACIDA FISIOLOGICAMENTE COMPATIBLES, SE TRATA L-ISOIDIDO, D-ISOSORBID O D-ISOMANNIDO CON UN CLORURO DE ACIDO SULFONICO. EL PRODUCTO OBTENIDO SE HACE REACCIONAR MEDIANTE AMINOLISIS CON SOLUCION ACUOSA D AMONIACO O UNA ALQUILAMINA PRIMARIA DE C -C . SE ESTERIFICA EL GRUPO HIDROXILO LIBRE DEL AMINO-DESOXI-1.4;3.6-DIANHIDRO-BOXITO ASI FORMADO POR EJEMPLO CON ACIDO NITRICO, EN PRESENCIA DE UREA. SE HACE REACCIONAR, POR ULTIMO, EL NITRATO OBTENIDO CON EL CORRESPONDIENTE DERIVADO DE W-HALOGENO-ALQUILO, EPOXIALQUILO U W-ACILOXIALQUILXANTINO O ADENINA. >SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIAS Y ANGINA D PECHO.
ES503485A 1980-07-25 1981-06-29 Procedimiento para la preparacion de nitratos de alquilami- nodesoxi-1.4,3.6-dianhidro-hexito sustituidos con bases pu- rinicas Expired ES8301239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803028272 DE3028272A1 (de) 1980-07-25 1980-07-25 Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung

Publications (2)

Publication Number Publication Date
ES503485A0 ES503485A0 (es) 1982-11-16
ES8301239A1 true ES8301239A1 (es) 1982-11-16

Family

ID=6108125

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503485A Expired ES8301239A1 (es) 1980-07-25 1981-06-29 Procedimiento para la preparacion de nitratos de alquilami- nodesoxi-1.4,3.6-dianhidro-hexito sustituidos con bases pu- rinicas

Country Status (9)

Country Link
US (1) US4542137A (es)
EP (1) EP0044927B1 (es)
JP (1) JPS5758692A (es)
AR (1) AR231141A1 (es)
AT (1) ATE10498T1 (es)
CA (1) CA1186687A (es)
DE (1) DE3028272A1 (es)
ES (1) ES8301239A1 (es)
MX (1) MX157614A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
DE3704604A1 (de) * 1987-02-13 1988-08-25 Mack Chem Pharm Oximether von 2,6-dioxabicyclo(3.3.0)octanonen, herstellungsverfahren und anwendung als arzneimittel
CA2014520C (en) * 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852507A (en) * 1955-02-23 1958-09-16 Eastman Kodak Co Method of preparing powdered salt-free cellulose acetate-dicarboxylates
DE1100640B (de) * 1956-09-25 1961-03-02 Chemiewerk Homburg Verfahren zur Herstellung von basisch substituierten Alkylxanthin-Derivaten
DE1221641B (de) * 1962-03-30 1966-07-28 Degussa Verfahren zur Herstellung von basisch substituierten Theophyllinderivaten
DE1545634A1 (de) * 1965-10-15 1969-08-07 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Ketalen
DE1545635A1 (de) * 1965-10-16 1969-08-07 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Derivaten
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US4000137A (en) * 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4087603A (en) * 1976-09-27 1978-05-02 Eli Lilly And Company Antifungal antibiotics
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
JPS55113786A (en) * 1979-02-23 1980-09-02 Toyo Jozo Co Ltd Novel substance, nepranosin b or f and its preparation
DE3028288A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung

Also Published As

Publication number Publication date
DE3028272C2 (es) 1990-09-13
JPS5758692A (en) 1982-04-08
ATE10498T1 (de) 1984-12-15
AR231141A1 (es) 1984-09-28
ES503485A0 (es) 1982-11-16
EP0044927A1 (de) 1982-02-03
CA1186687A (en) 1985-05-07
MX157614A (es) 1988-12-06
JPS6248674B2 (es) 1987-10-15
US4542137A (en) 1985-09-17
EP0044927B1 (de) 1984-11-28
DE3028272A1 (de) 1982-02-25

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