ES8407033A1 - Un procedimiento para la preparacion de derivados de benzotiazolina. - Google Patents

Un procedimiento para la preparacion de derivados de benzotiazolina.

Info

Publication number
ES8407033A1
ES8407033A1 ES522386A ES522386A ES8407033A1 ES 8407033 A1 ES8407033 A1 ES 8407033A1 ES 522386 A ES522386 A ES 522386A ES 522386 A ES522386 A ES 522386A ES 8407033 A1 ES8407033 A1 ES 8407033A1
Authority
ES
Spain
Prior art keywords
group
alkyl group
substituted
lower alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522386A
Other languages
English (en)
Other versions
ES522386A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of ES8407033A1 publication Critical patent/ES8407033A1/es
Publication of ES522386A0 publication Critical patent/ES522386A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZOTIAZOLINA, DE FORMULA GENERAL (I), Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO AMINICO. LOS COMPUESTOS OBTENIDOS SE PUEDEN CONVERTIR EN SALES DE ACIDOS ORGANICOS O INORGANICOS, TALES COMO HIDROCLORUROS, SULFATOS, FOSFATOS, LACTADOS, MALEATOS O FUMARATOS.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES.
ES522386A 1981-09-12 1983-05-13 Un procedimiento para la preparacion de derivados de benzotiazolina. Granted ES522386A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56144148A JPS5846079A (ja) 1981-09-12 1981-09-12 ベンゾチアゾリン環を有するエ−テル類

Publications (2)

Publication Number Publication Date
ES8407033A1 true ES8407033A1 (es) 1984-08-16
ES522386A0 ES522386A0 (es) 1984-08-16

Family

ID=15355326

Family Applications (2)

Application Number Title Priority Date Filing Date
ES515655A Expired ES8308552A1 (es) 1981-09-12 1982-09-10 Un procedimiento para la preparacion de derivados de benzotiazolina.
ES522386A Granted ES522386A0 (es) 1981-09-12 1983-05-13 Un procedimiento para la preparacion de derivados de benzotiazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES515655A Expired ES8308552A1 (es) 1981-09-12 1982-09-10 Un procedimiento para la preparacion de derivados de benzotiazolina.

Country Status (18)

Country Link
US (3) US4479949A (es)
JP (1) JPS5846079A (es)
AT (1) AT379592B (es)
AU (1) AU541223B2 (es)
BE (1) BE894358A (es)
CA (1) CA1169860A (es)
CH (1) CH654001A5 (es)
DE (1) DE3248957T1 (es)
DK (1) DK164403C (es)
ES (2) ES8308552A1 (es)
FI (1) FI68232C (es)
FR (1) FR2512820B1 (es)
GB (1) GB2115815B (es)
IT (1) IT1196423B (es)
NL (1) NL8220310A (es)
NO (1) NO831653L (es)
SE (1) SE444681B (es)
WO (1) WO1983000865A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56164877A (en) * 1980-05-23 1981-12-18 Fujitsu Ltd Manufacture of head for thermal printer
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
DK143684A (da) * 1983-03-12 1984-09-13 Bayer Ag Anvendelse af pyrazolonderivater som lipoxygenasehaemmer ved terapi af isaer ischaemi og hjerterytmeforstyrrelser
JPS60139679A (ja) * 1983-12-27 1985-07-24 Santen Pharmaceut Co Ltd ２−アリ−ルベンゾチアゾリン誘導体
JPS60207396A (ja) * 1984-03-31 1985-10-18 ロ−ム株式会社 配線基板
JPS61110568A (ja) * 1984-10-31 1986-05-28 アルカテル・エヌ・ブイ プリンタ装置
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
JPS62221679A (ja) * 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
EP2042173A3 (en) * 2002-03-29 2010-02-24 Santen Pharmaceutical Co., Ltd. Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
JP6275517B2 (ja) * 2013-03-22 2018-02-07 あゆみ製薬株式会社 Ｉｌ−２産生抑制

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2996512A (en) * 1961-08-15 Therapeutic derivatives of aryl-
US3117124A (en) * 1957-03-20 1964-01-07 Olin Mathieson Benzothiazole, benzothiazine, and benzothiazepine compounds
FR1255312A (fr) * 1957-10-31 1961-03-10 Crookes Lab Ltd Dérivés des aryl-benzothiazoles et leur mode de préparation
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
GB1047927A (en) * 1964-03-09 1966-11-09 Ici Ltd Alkanolamine derivatives
BE754245A (fr) * 1969-08-01 1970-12-31 Sumitomo Chemical Co Derives d'acides phenoxy carboxyliques
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
US3720683A (en) * 1970-09-02 1973-03-13 Squibb & Sons Inc 2-phenyl-3-acylbenzothiazolines and their oxides
JPS5371071A (en) * 1976-12-08 1978-06-24 Teijin Ltd Alpha-phenoxyacetic acid derivs.
JPS57179175A (en) * 1981-04-30 1982-11-04 Shinzo Kano Preparation of 2-benzothiazolinone derivative or salt thereof
JPS5846079A (ja) * 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類

Also Published As

Publication number Publication date
JPS5846079A (ja) 1983-03-17
DK164403B (da) 1992-06-22
SE8302352L (sv) 1983-04-26
FR2512820A1 (fr) 1983-03-18
DK211283A (da) 1983-05-11
IT1196423B (it) 1988-11-16
CA1169860A (en) 1984-06-26
FI831431L (fi) 1983-04-27
ES515655A0 (es) 1983-09-16
DE3248957C2 (es) 1989-09-21
FI831431A0 (fi) 1983-04-27
US4558125A (en) 1985-12-10
US4479949A (en) 1984-10-30
NO831653L (no) 1983-05-10
SE444681B (sv) 1986-04-28
DK164403C (da) 1992-11-16
CH654001A5 (de) 1986-01-31
ATA904882A (de) 1985-06-15
AU541223B2 (en) 1984-12-20
FI68232B (fi) 1985-04-30
WO1983000865A1 (en) 1983-03-17
GB2115815A (en) 1983-09-14
FI68232C (fi) 1985-08-12
DK211283D0 (da) 1983-05-11
BE894358A (fr) 1983-01-03
ES522386A0 (es) 1984-08-16
DE3248957T1 (de) 1983-10-20
GB8311096D0 (en) 1983-05-25
FR2512820B1 (fr) 1986-11-21
AU8902682A (en) 1983-03-28
AT379592B (de) 1986-01-27
US4552969A (en) 1985-11-12
SE8302352D0 (sv) 1983-04-26
ES8308552A1 (es) 1983-09-16
NL8220310A (nl) 1983-08-01
GB2115815B (en) 1985-06-19
IT8223146A0 (it) 1982-09-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000403