ES8200108A1 - Un procedimiento para la preparacion de derivados de tioxan tina. - Google Patents

Un procedimiento para la preparacion de derivados de tioxan tina.

Info

Publication number
ES8200108A1
ES8200108A1 ES490290A ES490290A ES8200108A1 ES 8200108 A1 ES8200108 A1 ES 8200108A1 ES 490290 A ES490290 A ES 490290A ES 490290 A ES490290 A ES 490290A ES 8200108 A1 ES8200108 A1 ES 8200108A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
carbon atoms
alkyl group
xanthine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490290A
Other languages
English (en)
Other versions
ES490290A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WUELFING JOHANN A KG
Original Assignee
WUELFING JOHANN A KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WUELFING JOHANN A KG filed Critical WUELFING JOHANN A KG
Publication of ES8200108A1 publication Critical patent/ES8200108A1/es
Publication of ES490290A0 publication Critical patent/ES490290A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TIOXANTINA. SE HACE REACCIONAR UNA SAL DE UN COMPUESTO DE FORMULA (I), EN DONDE X E Y SON AZUFRE, O BIEN UNO ES OXIGENO Y EL OTRO AZUFRE; R1 Y R2 SON GRUPOS ALQUILO DE HASTA 6 ATOMOS DE CARBONO, CON UN COMPUESTO DE FORMULA (II) O EN UN EQUIVALENTE QUIMICO DEL MISMO, DONDE "M" ES 0 O 1 Y "N" VALE DE 0 A 6, PARA DAR UN COMPUESTO DE FORMULA (III). LA REACCION SE LLEVA A CABO A TEMPERATURA AMBIENTE O ELEVADA, 20-80 C, Y EN UN DISOLVENTE TAL COMO METANOL, ETANOL O SIMILARES. SE UTILIZAN COMO FAVORECEDORES DEL FLUJO SANGUINEO.
ES490290A 1979-04-05 1980-04-02 Un procedimiento para la preparacion de derivados de tioxan tina. Granted ES490290A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7912052 1979-04-05
GB7919505 1979-06-05

Publications (2)

Publication Number Publication Date
ES8200108A1 true ES8200108A1 (es) 1981-10-16
ES490290A0 ES490290A0 (es) 1981-10-16

Family

ID=26271144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490290A Granted ES490290A0 (es) 1979-04-05 1980-04-02 Un procedimiento para la preparacion de derivados de tioxan tina.

Country Status (10)

Country Link
US (1) US4454138A (es)
EP (1) EP0018136B1 (es)
AU (1) AU531481B2 (es)
CA (1) CA1128509A (es)
DE (1) DE3065580D1 (es)
DK (1) DK147795C (es)
ES (1) ES490290A0 (es)
IE (1) IE49662B1 (es)
IL (1) IL59665A0 (es)
NZ (1) NZ193286A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment
GB8621869D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Treatment
US4965271A (en) * 1986-12-31 1990-10-23 Hoechst Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5096906A (en) * 1986-12-31 1992-03-17 University Of Virginia Alumni Patents Foundation Method of inhibiting the activity of leukocyte derived cytokines
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
DE69531555T2 (de) 1994-12-13 2004-06-17 Euroceltique S.A. Dreifachsubstituierte thioxanthine
EP0814809B1 (en) 1994-12-13 2003-08-13 Euroceltique S.A. Aryl thioxanthines
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5919474A (en) * 1997-10-28 1999-07-06 Vivus, Inc. Transurethral administration of vasoactive agents to treat peripheral vascular disease, related vascular diseases, and vascular impotence associated therewith

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2756229A (en) * 1956-07-24 Xanthine derivatives
GB759174A (en) * 1952-11-07 1956-10-17 Geigy Ag J R Improvements in diuretic acting xanthine derivatives
US3737433A (en) * 1964-09-05 1973-06-05 Albert Ag Chem Werke Certain oxoalkyldimethylxanthines
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH608236A5 (es) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4225607A (en) * 1979-05-14 1980-09-30 Johann A. Wulfing Pharmaceutical composition containing a xanthine derivative

Also Published As

Publication number Publication date
IE49662B1 (en) 1985-11-13
US4454138A (en) 1984-06-12
EP0018136B1 (en) 1983-11-16
NZ193286A (en) 1982-05-25
DK148580A (da) 1980-10-06
DK147795C (da) 1985-08-19
EP0018136A1 (en) 1980-10-29
DE3065580D1 (en) 1983-12-22
AU531481B2 (en) 1983-08-25
AU5719080A (en) 1981-01-15
IL59665A0 (en) 1980-06-30
CA1128509A (en) 1982-07-27
ES490290A0 (es) 1981-10-16
IE800688L (en) 1980-10-05
DK147795B (da) 1984-12-10

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