ES8204994A1 - Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles - Google Patents

Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles

Info

Publication number
ES8204994A1
ES8204994A1 ES503486A ES503486A ES8204994A1 ES 8204994 A1 ES8204994 A1 ES 8204994A1 ES 503486 A ES503486 A ES 503486A ES 503486 A ES503486 A ES 503486A ES 8204994 A1 ES8204994 A1 ES 8204994A1
Authority
ES
Spain
Prior art keywords
substituted
atoms
pharmaceutical compositions
preparation
purine bases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503486A
Other languages
English (en)
Other versions
ES503486A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of ES503486A0 publication Critical patent/ES503486A0/es
Publication of ES8204994A1 publication Critical patent/ES8204994A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NITRATOS DE 1. 4; 3. 6-DIANHIDRO-HEXITO, SUSTITUIDOS POR BASES PURINICAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 PUEEN SER VARIOS TIPOS DE RADICALES, Y LA BASE PRUINICA PUEDE SER TAMBIEN DEL TIPO TEOFILINA. CONSISTE EN LA REACCION DEL 6-ISOIDIDO, D-ISOMANNIDO CON UN CLORURO DE ACIDO SULFONICO, SEGUIDA DE LA REACCION CON UNA SAL ALCALINA DE LA ADENINA O DE UNA ADENINA SUSTIUIDA CON N EN POSICION 6, DE LA 6-METILMERCAPTOPURINA O 6-CLOROPURINA; POSTERIOR REACCION EVENTUAL DEL GRUPO 6-METILMERCAPTO O DEL ATOMO DE CLORO EN POSICION 6 CON UNA ALQUILAMINA PRIMARIA O SECUNDARIA ADECUSADAS, DE CLORO EN POSICION 6 CON UNA ALQUILAMINA PRIMARIA O SECUNDARIA ADECUADAS, ESTERIFICACION DEL GRUPO HIDROXILO LIBRE FORMDO CON ACIDO NITRICO O MEZCLAS NITRICOSULFURICAS O NITRICOACETICAS Y, FINALMENTE, EVENTUAL ACILACION DEL GRUPO 6-AMINO O 6-AMINOMONOSUSTITUIDO DEL RADICAL ADENINO, POR REACCION CON UN ACIDO CARBOXILICO.
ES503486A 1980-07-25 1981-06-29 Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles Expired ES8204994A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803028273 DE3028273A1 (de) 1980-07-25 1980-07-25 Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate

Publications (2)

Publication Number Publication Date
ES503486A0 ES503486A0 (es) 1982-05-16
ES8204994A1 true ES8204994A1 (es) 1982-05-16

Family

ID=6108126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503486A Expired ES8204994A1 (es) 1980-07-25 1981-06-29 Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles

Country Status (7)

Country Link
US (2) US4479951A (es)
EP (1) EP0044928B1 (es)
JP (1) JPS5764700A (es)
AT (1) ATE12117T1 (es)
CA (1) CA1190544A (es)
DE (1) DE3028273A1 (es)
ES (1) ES8204994A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028288A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
CA2014520C (en) * 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
ES2103918T3 (es) * 1991-10-17 1997-10-01 Ciba Geigy Ag Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios.
AU4772493A (en) * 1992-07-15 1994-02-14 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Sulfo-derivatives of adenosine
ES2132419T3 (es) 1993-07-23 1999-08-16 Merrell Pharma Inc Nuevos agentes de nucleosidos 9-n-biciclicos utiles como inhibidores selectivos de citocinas proinflamatorias.
US6110923A (en) * 1994-06-22 2000-08-29 Biochem Pharma Inc. Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
US5786360A (en) 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
US7202252B2 (en) 2003-02-19 2007-04-10 Endacea, Inc. A1 adenosine receptor antagonists
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
US20090068101A9 (en) * 2003-06-09 2009-03-12 Endacea, Inc. A1 Adenosine Receptor Antagonists
US8127691B2 (en) * 2004-03-03 2012-03-06 Fitzpatrick Technologies, Llc SMC pallet
US20060081158A1 (en) * 2004-10-19 2006-04-20 Fitzpatrick Technologies, L.L.C. Pultrusion pallet
US20070017423A1 (en) * 2005-07-19 2007-01-25 Ingham Terry L Pallet With Recycled Components
US20070017422A1 (en) * 2005-07-19 2007-01-25 Fitzpatrick Technologies, Llc Pallet with composite components
US8261673B2 (en) * 2007-09-26 2012-09-11 Fitzpatrick Technologies Pallet with lead board

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852506A (en) * 1955-10-31 1958-09-16 American Cyanamid Co Method of preparing aminodeoxyglycosidopurines
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
US4000137A (en) * 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4087603A (en) * 1976-09-27 1978-05-02 Eli Lilly And Company Antifungal antibiotics
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
JPS55113786A (en) * 1979-02-23 1980-09-02 Toyo Jozo Co Ltd Novel substance, nepranosin b or f and its preparation
IL59664A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
DE3028272A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung

Also Published As

Publication number Publication date
EP0044928B1 (de) 1985-03-13
CA1190544A (en) 1985-07-16
US4479951A (en) 1984-10-30
ES503486A0 (es) 1982-05-16
JPH0247476B2 (es) 1990-10-19
EP0044928A1 (de) 1982-02-03
DE3028273C2 (es) 1989-12-14
US4622324A (en) 1986-11-11
JPS5764700A (en) 1982-04-19
DE3028273A1 (de) 1982-02-25
ATE12117T1 (de) 1985-03-15

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