ES8204994A1 - Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles - Google Patents
Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatiblesInfo
- Publication number
- ES8204994A1 ES8204994A1 ES503486A ES503486A ES8204994A1 ES 8204994 A1 ES8204994 A1 ES 8204994A1 ES 503486 A ES503486 A ES 503486A ES 503486 A ES503486 A ES 503486A ES 8204994 A1 ES8204994 A1 ES 8204994A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- atoms
- pharmaceutical compositions
- preparation
- purine bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE NITRATOS DE 1. 4; 3. 6-DIANHIDRO-HEXITO, SUSTITUIDOS POR BASES PURINICAS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 PUEEN SER VARIOS TIPOS DE RADICALES, Y LA BASE PRUINICA PUEDE SER TAMBIEN DEL TIPO TEOFILINA. CONSISTE EN LA REACCION DEL 6-ISOIDIDO, D-ISOMANNIDO CON UN CLORURO DE ACIDO SULFONICO, SEGUIDA DE LA REACCION CON UNA SAL ALCALINA DE LA ADENINA O DE UNA ADENINA SUSTIUIDA CON N EN POSICION 6, DE LA 6-METILMERCAPTOPURINA O 6-CLOROPURINA; POSTERIOR REACCION EVENTUAL DEL GRUPO 6-METILMERCAPTO O DEL ATOMO DE CLORO EN POSICION 6 CON UNA ALQUILAMINA PRIMARIA O SECUNDARIA ADECUSADAS, DE CLORO EN POSICION 6 CON UNA ALQUILAMINA PRIMARIA O SECUNDARIA ADECUADAS, ESTERIFICACION DEL GRUPO HIDROXILO LIBRE FORMDO CON ACIDO NITRICO O MEZCLAS NITRICOSULFURICAS O NITRICOACETICAS Y, FINALMENTE, EVENTUAL ACILACION DEL GRUPO 6-AMINO O 6-AMINOMONOSUSTITUIDO DEL RADICAL ADENINO, POR REACCION CON UN ACIDO CARBOXILICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803028273 DE3028273A1 (de) | 1980-07-25 | 1980-07-25 | Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES503486A0 ES503486A0 (es) | 1982-05-16 |
ES8204994A1 true ES8204994A1 (es) | 1982-05-16 |
Family
ID=6108126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503486A Expired ES8204994A1 (es) | 1980-07-25 | 1981-06-29 | Procedimiento de preparacion de nitratos de 1.4,3.6-dian- hidro-hexito,sustituidos por bases purinicas,asi como de sussales de adicion acidas fisiologicamente compatibles |
Country Status (7)
Country | Link |
---|---|
US (2) | US4479951A (es) |
EP (1) | EP0044928B1 (es) |
JP (1) | JPS5764700A (es) |
AT (1) | ATE12117T1 (es) |
CA (1) | CA1190544A (es) |
DE (1) | DE3028273A1 (es) |
ES (1) | ES8204994A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3028288A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung |
JPS6094992A (ja) * | 1983-10-28 | 1985-05-28 | Sankyo Co Ltd | グリゼオ−ル酸誘導体 |
DE3421072A1 (de) * | 1984-06-06 | 1985-12-12 | Heinrich Mack Nachf., 7918 Illertissen | 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE8817122U1 (es) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
CA2014520C (en) * | 1989-04-17 | 1996-07-16 | Fumio Suzuki | Hexitol derivatives |
EP0538194B1 (de) * | 1991-10-17 | 1997-06-04 | Novartis AG | Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte |
WO1994002497A1 (en) * | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
EP0710239B1 (en) | 1993-07-23 | 1999-02-10 | Merrell Pharmaceuticals Inc. | Novel 9-n-bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines |
US6110923A (en) * | 1994-06-22 | 2000-08-29 | Biochem Pharma Inc. | Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity |
US5786360A (en) * | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
JP2006518390A (ja) | 2003-02-19 | 2006-08-10 | エンダシア,インコーポレイテッド | A1アデノシンレセプターアンタゴニスト |
EP1636229A4 (en) * | 2003-06-06 | 2008-07-30 | Endacea Inc | ADENOSINE A1 RECEPTOR ANTAGONISTS |
CA2528367A1 (en) * | 2003-06-09 | 2004-12-23 | Endacea, Inc. | A1 adenosine receptor antagonists |
US8127691B2 (en) * | 2004-03-03 | 2012-03-06 | Fitzpatrick Technologies, Llc | SMC pallet |
US20060081158A1 (en) * | 2004-10-19 | 2006-04-20 | Fitzpatrick Technologies, L.L.C. | Pultrusion pallet |
US20070017422A1 (en) * | 2005-07-19 | 2007-01-25 | Fitzpatrick Technologies, Llc | Pallet with composite components |
US20070017423A1 (en) * | 2005-07-19 | 2007-01-25 | Ingham Terry L | Pallet With Recycled Components |
WO2009042872A1 (en) * | 2007-09-26 | 2009-04-02 | Fitzpatrick Technologies | Pallet with lead board |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2852506A (en) * | 1955-10-31 | 1958-09-16 | American Cyanamid Co | Method of preparing aminodeoxyglycosidopurines |
US3886186A (en) * | 1971-04-29 | 1975-05-27 | American Home Prod | Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol |
US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
US4087603A (en) * | 1976-09-27 | 1978-05-02 | Eli Lilly And Company | Antifungal antibiotics |
US4065488A (en) * | 1977-02-24 | 1977-12-27 | American Home Products Corporation | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate |
JPS55113786A (en) * | 1979-02-23 | 1980-09-02 | Toyo Jozo Co Ltd | Novel substance, nepranosin b or f and its preparation |
IL59664A0 (en) * | 1979-04-05 | 1980-06-30 | Wuelfing J Kg | Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions |
DE3028272A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung |
-
1980
- 1980-07-25 DE DE19803028273 patent/DE3028273A1/de active Granted
-
1981
- 1981-06-11 AT AT81104476T patent/ATE12117T1/de not_active IP Right Cessation
- 1981-06-11 EP EP81104476A patent/EP0044928B1/de not_active Expired
- 1981-06-29 ES ES503486A patent/ES8204994A1/es not_active Expired
- 1981-07-08 CA CA000381368A patent/CA1190544A/en not_active Expired
- 1981-07-20 US US06/285,406 patent/US4479951A/en not_active Expired - Fee Related
- 1981-07-24 JP JP56116321A patent/JPS5764700A/ja active Granted
-
1984
- 1984-08-17 US US06/642,140 patent/US4622324A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3028273A1 (de) | 1982-02-25 |
CA1190544A (en) | 1985-07-16 |
DE3028273C2 (es) | 1989-12-14 |
US4622324A (en) | 1986-11-11 |
EP0044928B1 (de) | 1985-03-13 |
ES503486A0 (es) | 1982-05-16 |
US4479951A (en) | 1984-10-30 |
JPH0247476B2 (es) | 1990-10-19 |
ATE12117T1 (de) | 1985-03-15 |
EP0044928A1 (de) | 1982-02-03 |
JPS5764700A (en) | 1982-04-19 |
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