GB2015338A - Pharmaceutical compositions containing ergot alkaloids and heparin - Google Patents

Pharmaceutical compositions containing ergot alkaloids and heparin

Info

Publication number
GB2015338A
GB2015338A GB7907393A GB7907393A GB2015338A GB 2015338 A GB2015338 A GB 2015338A GB 7907393 A GB7907393 A GB 7907393A GB 7907393 A GB7907393 A GB 7907393A GB 2015338 A GB2015338 A GB 2015338A
Authority
GB
United Kingdom
Prior art keywords
heparin
pharmaceutical compositions
compositions containing
ergot alkaloids
mgs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7907393A
Other versions
GB2015338B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB2015338A publication Critical patent/GB2015338A/en
Application granted granted Critical
Publication of GB2015338B publication Critical patent/GB2015338B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A pharmaceutical composition comprises a mixture of a hydrogenated ergot alkaloid of formula (I):- <IMAGE> wherein R is hydrogen or a C1-4 alkyl group other than t-butyl; R1 is methyl, ethyl or isopropyl; R2 is isopropyl, secbutyl, isobutyl or benzyl; and X is hydrogen or methoxy; together with heparin, the proportion of compound (I) in mgs. to heparin in international Units being 1:5000. The composition may be in unit dosage form containing 0.5 mgs. of the alkaloid and 2,500 I.U. of heparin, together with a pharmaceutical carrier or diluent for injection (eg. poly-N- vinyl-2-pyrrolidone).
GB7907393A 1978-03-06 1979-03-02 Pharmaceutical compositions containg ergot alkaloids and heparing Expired GB2015338B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782809618 DE2809618A1 (en) 1978-03-06 1978-03-06 NEW THERAPEUTIC PREPARATION AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
GB2015338A true GB2015338A (en) 1979-09-12
GB2015338B GB2015338B (en) 1982-08-18

Family

ID=6033695

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7907393A Expired GB2015338B (en) 1978-03-06 1979-03-02 Pharmaceutical compositions containg ergot alkaloids and heparing

Country Status (15)

Country Link
JP (1) JPS54126736A (en)
BE (1) BE874626R (en)
CH (1) CH639271A5 (en)
CY (1) CY1298A (en)
DE (1) DE2809618A1 (en)
FR (1) FR2419070A2 (en)
GB (1) GB2015338B (en)
HK (1) HK81085A (en)
IE (1) IE48192B1 (en)
KE (1) KE3548A (en)
NL (1) NL7901702A (en)
NZ (1) NZ189817A (en)
PH (1) PH16800A (en)
SG (1) SG49185G (en)
ZA (1) ZA791032B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028813A2 (en) * 1979-11-12 1981-05-20 Sandoz Ag Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations
FR2537435A1 (en) * 1982-12-10 1984-06-15 Sandoz Sa NEW DRUG ASSOCIATION BASED ON A HYDROGEN ALKALOID OF ERGOT AND HEPARIN

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3343818A1 (en) * 1982-12-10 1984-06-14 Sandoz-Patent-GmbH, 7850 Lörrach Therapeutic product containing hydrogenated ergot alkaloids and heparin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE441142B (en) * 1975-12-04 1985-09-16 Sandoz Ag PROCEDURE FOR PREPARING A THERAPEUTIC PREPARATION WITH ANTITHROMOBOTIC PROPERTIES

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028813A2 (en) * 1979-11-12 1981-05-20 Sandoz Ag Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations
EP0028813A3 (en) * 1979-11-12 1982-08-25 Sandoz Ag Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations
FR2537435A1 (en) * 1982-12-10 1984-06-15 Sandoz Sa NEW DRUG ASSOCIATION BASED ON A HYDROGEN ALKALOID OF ERGOT AND HEPARIN

Also Published As

Publication number Publication date
FR2419070A2 (en) 1979-10-05
ZA791032B (en) 1980-10-29
HK81085A (en) 1985-10-25
KE3548A (en) 1985-08-02
CY1298A (en) 1985-10-18
DE2809618A1 (en) 1979-09-20
SG49185G (en) 1986-01-17
GB2015338B (en) 1982-08-18
CH639271A5 (en) 1983-11-15
NZ189817A (en) 1981-04-24
JPS54126736A (en) 1979-10-02
FR2419070B1 (en) 1982-08-06
PH16800A (en) 1984-03-01
IE790701L (en) 1979-09-06
IE48192B1 (en) 1984-10-31
BE874626R (en) 1979-09-05
NL7901702A (en) 1979-09-10

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee