ES8206537A1 - Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina - Google Patents

Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina

Info

Publication number
ES8206537A1
ES8206537A1 ES504259A ES504259A ES8206537A1 ES 8206537 A1 ES8206537 A1 ES 8206537A1 ES 504259 A ES504259 A ES 504259A ES 504259 A ES504259 A ES 504259A ES 8206537 A1 ES8206537 A1 ES 8206537A1
Authority
ES
Spain
Prior art keywords
carbon atoms
represent
unsubstituted alkyl
thiazolo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504259A
Other languages
English (en)
Other versions
ES504259A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8016319A external-priority patent/FR2487355A1/fr
Priority claimed from FR8109724A external-priority patent/FR2505842A1/fr
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES8206537A1 publication Critical patent/ES8206537A1/es
Publication of ES504259A0 publication Critical patent/ES504259A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA TIAZOLO (382-A) PIRIMIDINA DE FORMULA (I), EN LA QUE R, R1,R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN HALOGENURO DE FORMULA (II) CON UNA AMINO-2-TIAZOLINA-2, EN EQUILIBRIO CON SU FORMA IMINA DE FORMULA (III), EN LAS QUE X ES UN ATOMO DE HALOGENO Y R, R1, R2, Y R3 SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE 20 C. Y LA DE REFLUJO DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES FAMACOLOGICAS POR SU ACTIVIDAD ANALGESICA Y ANTIALERGICA.
ES504259A 1980-07-24 1981-07-24 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina Granted ES504259A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8016319A FR2487355A1 (fr) 1980-07-24 1980-07-24 Nouveaux derives de la thiazolo (3,2-a) pyrimidine, leur preparation et les medicaments qui les contiennent
FR8109724A FR2505842A1 (fr) 1981-05-15 1981-05-15 Nouveaux derives de la tetrahydro-2,3,6,7 thiazolo (3,2-a) pyrimidinone-5, leur preparation et les medicaments qui les contiennent

Publications (2)

Publication Number Publication Date
ES8206537A1 true ES8206537A1 (es) 1982-08-16
ES504259A0 ES504259A0 (es) 1982-08-16

Family

ID=26221908

Family Applications (3)

Application Number Title Priority Date Filing Date
ES504259A Granted ES504259A0 (es) 1980-07-24 1981-07-24 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a) pirimidina
ES505896A Granted ES505896A0 (es) 1980-07-24 1981-09-30 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
ES505897A Granted ES505897A0 (es) 1980-07-24 1981-09-30 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES505896A Granted ES505896A0 (es) 1980-07-24 1981-09-30 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
ES505897A Granted ES505897A0 (es) 1980-07-24 1981-09-30 Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina

Country Status (17)

Country Link
US (1) US4419356A (es)
EP (1) EP0045251B1 (es)
KR (1) KR850000013B1 (es)
AT (1) ATE5480T1 (es)
AU (1) AU542548B2 (es)
CA (1) CA1162923A (es)
DE (1) DE3161553D1 (es)
DK (1) DK329081A (es)
ES (3) ES504259A0 (es)
GR (1) GR74920B (es)
HU (1) HU181814B (es)
IE (1) IE51420B1 (es)
NO (1) NO812527L (es)
NZ (1) NZ197800A (es)
PH (1) PH16523A (es)
PL (2) PL129375B1 (es)
SU (2) SU1091859A3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530636A1 (fr) * 1982-07-23 1984-01-27 Rhone Poulenc Agrochimie Nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo (3,2-a) pyrimidine, leur preparation et leur utilisation comme herbicides
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
FR2574408B1 (fr) * 1984-12-12 1987-01-30 Rhone Poulenc Sante Procede de preparation d'isomeres optiques de thiazolo(3,2-a) pyrimidines, les nouveaux isomeres ainsi obtenus, les compositions pharmaceutiques qui les contiennent et les intermediaires pour mettre en oeuvre ce procede
NO941135L (no) * 1993-04-01 1994-10-03 Daiichi Seiyaku Co Tiazolpyrimidin derivater
DOP2002000334A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888983A (en) * 1970-08-14 1975-06-10 Seperic Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia
GB1306558A (en) * 1970-08-14 1973-02-14 Seperic Derivatives of thiazolino-pyrimidin-5-ones their preparation and applications
BE778911R (en) * 1972-02-03 1972-05-30 Seperic 7-substd-2,3-dihydrothiazolo(3,2,a) pyrimidin-5-ones - - analgesics
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines

Also Published As

Publication number Publication date
PL129612B1 (en) 1984-05-31
SU1145932A3 (ru) 1985-03-15
ES504259A0 (es) 1982-08-16
IE811653L (en) 1982-01-24
PL235882A1 (es) 1982-12-20
ES8300116A1 (es) 1982-10-01
EP0045251A1 (fr) 1982-02-03
KR830006316A (ko) 1983-09-20
PL232302A1 (es) 1982-08-16
AU7318181A (en) 1982-01-28
ES8300776A1 (es) 1982-11-01
KR850000013B1 (ko) 1985-02-08
US4419356A (en) 1983-12-06
EP0045251B1 (fr) 1983-11-30
PL129375B1 (en) 1984-05-31
NO812527L (no) 1982-01-25
CA1162923A (fr) 1984-02-28
AU542548B2 (en) 1985-02-28
HU181814B (en) 1983-11-28
PH16523A (en) 1983-11-10
GR74920B (es) 1984-07-12
DE3161553D1 (en) 1984-01-05
ES505897A0 (es) 1982-11-01
DK329081A (da) 1982-01-25
IE51420B1 (en) 1986-12-24
ATE5480T1 (de) 1983-12-15
NZ197800A (en) 1983-05-31
ES505896A0 (es) 1982-10-01
SU1091859A3 (ru) 1984-05-07

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