ZA859462B - New pteridines,processes for preparing them and their use as intermediate products or as pharmaceutical compositions - Google Patents

New pteridines,processes for preparing them and their use as intermediate products or as pharmaceutical compositions

Info

Publication number
ZA859462B
ZA859462B ZA859462A ZA859462A ZA859462B ZA 859462 B ZA859462 B ZA 859462B ZA 859462 A ZA859462 A ZA 859462A ZA 859462 A ZA859462 A ZA 859462A ZA 859462 B ZA859462 B ZA 859462B
Authority
ZA
South Africa
Prior art keywords
preparing
processes
pharmaceutical compositions
intermediate products
pteridines
Prior art date
Application number
ZA859462A
Inventor
Josef Roch
Armin Heckel
Josef Nickl
Erich Mueller
Berthold Narr
Rainer Zimmermann
Hans Weisenberger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA859462B publication Critical patent/ZA859462B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/06Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA859462A 1984-12-12 1985-12-11 New pteridines,processes for preparing them and their use as intermediate products or as pharmaceutical compositions ZA859462B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843445298 DE3445298A1 (en) 1984-12-12 1984-12-12 NEW PTERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS OR AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
ZA859462B true ZA859462B (en) 1987-07-29

Family

ID=6252576

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA859462A ZA859462B (en) 1984-12-12 1985-12-11 New pteridines,processes for preparing them and their use as intermediate products or as pharmaceutical compositions

Country Status (15)

Country Link
EP (1) EP0185259A3 (en)
JP (1) JPS61140585A (en)
AU (1) AU576924B2 (en)
CA (1) CA1252783A (en)
DE (1) DE3445298A1 (en)
DK (1) DK161327C (en)
ES (1) ES8707238A1 (en)
FI (1) FI82696C (en)
GR (1) GR852996B (en)
IL (1) IL77294A (en)
NO (1) NO161373C (en)
NZ (1) NZ214522A (en)
PH (1) PH24451A (en)
PT (1) PT81650B (en)
ZA (1) ZA859462B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
WO2003002064A2 (en) * 2001-06-28 2003-01-09 Essential Therapeutics, Inc. Fused pyrimidine dhfr inhibitors as antibacterials
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
DE602004009696T2 (en) * 2003-08-29 2008-08-28 4 Aza Ip Nv IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES
EP1673092B1 (en) * 2003-10-17 2007-08-15 4 Aza Ip Nv Heterocycle-substituted pteridine derivatives and their use in therapy
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
EP1720542A4 (en) * 2004-03-04 2007-11-28 Neurogen Corp Arylalkylamino-substituted quinazoline analogues
DE102004057595A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057618A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057645A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
PL1954699T3 (en) * 2005-11-22 2013-01-31 Kudos Pharm Ltd PYRIDO-, PYRAZO- AND PYRIMIDOPYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
RU2445315C2 (en) * 2005-11-22 2012-03-20 Кудос Фармасьютиклз Лимитед PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AND USE THEREOF AS mTOR INHIBITORS
WO2007135026A2 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines as therapeutic agents
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
SI2057156T1 (en) 2006-08-23 2017-06-30 Kudos Pharmaceuticals Limited 2-methylmorpholine pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors
CN102137860B (en) 2008-06-20 2013-08-28 阿斯利康(瑞典)有限公司 Pyrimidines composition and method for preparing same
SI3321265T1 (en) 2015-03-04 2020-07-31 Gilead Sciences, Inc. 4,6-diamino-pyrido(3,2-d)pyrimidine compounds and their utilisation as modulators of toll-like receptors
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
MA46093A (en) 2016-09-02 2021-05-19 Gilead Sciences Inc TOLL-TYPE RECEIVER MODULATING COMPOUNDS
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159628A (en) * 1962-05-28 1964-12-01 Smith Kline French Lab Pteridine-5-oxide derivatives
DE3323932A1 (en) * 1983-07-02 1985-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND

Also Published As

Publication number Publication date
NO161373C (en) 1989-08-09
PH24451A (en) 1990-06-25
PT81650B (en) 1988-04-21
CA1252783A (en) 1989-04-18
NZ214522A (en) 1988-07-28
DE3445298A1 (en) 1986-06-12
JPS61140585A (en) 1986-06-27
IL77294A (en) 1989-02-28
DK572685D0 (en) 1985-12-11
DK161327C (en) 1991-12-09
FI82696C (en) 1991-04-10
ES549806A0 (en) 1987-07-16
GR852996B (en) 1986-04-16
AU576924B2 (en) 1988-09-08
FI854862A0 (en) 1985-12-10
NO854965L (en) 1986-06-13
DK161327B (en) 1991-06-24
NO161373B (en) 1989-05-02
AU5123285A (en) 1986-06-19
FI854862A (en) 1986-06-13
PT81650A (en) 1986-01-01
EP0185259A2 (en) 1986-06-25
DK572685A (en) 1986-06-13
ES8707238A1 (en) 1987-07-16
FI82696B (en) 1990-12-31
EP0185259A3 (en) 1989-03-01

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