FI82696C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla pteridiner. - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla pteridiner. Download PDF

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Publication number
FI82696C
FI82696C FI854862A FI854862A FI82696C FI 82696 C FI82696 C FI 82696C FI 854862 A FI854862 A FI 854862A FI 854862 A FI854862 A FI 854862A FI 82696 C FI82696 C FI 82696C
Authority
FI
Finland
Prior art keywords
group
phenyl
pteridine
yield
melting point
Prior art date
Application number
FI854862A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI82696B (fi
FI854862A0 (fi
FI854862A (fi
Inventor
Berthold Narr
Erich Mueller
Josef Nickl
Armin Heckel
Josef Roch
Rainer Zimmermann
Johannes Weisenberger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI854862A0 publication Critical patent/FI854862A0/fi
Publication of FI854862A publication Critical patent/FI854862A/fi
Application granted granted Critical
Publication of FI82696B publication Critical patent/FI82696B/fi
Publication of FI82696C publication Critical patent/FI82696C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI854862A 1984-12-12 1985-12-10 Foerfarande foer framstaellning av farmakologiskt vaerdefulla pteridiner. FI82696C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3445298 1984-12-12
DE19843445298 DE3445298A1 (de) 1984-12-12 1984-12-12 Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel

Publications (4)

Publication Number Publication Date
FI854862A0 FI854862A0 (fi) 1985-12-10
FI854862A FI854862A (fi) 1986-06-13
FI82696B FI82696B (fi) 1990-12-31
FI82696C true FI82696C (fi) 1991-04-10

Family

ID=6252576

Family Applications (1)

Application Number Title Priority Date Filing Date
FI854862A FI82696C (fi) 1984-12-12 1985-12-10 Foerfarande foer framstaellning av farmakologiskt vaerdefulla pteridiner.

Country Status (15)

Country Link
EP (1) EP0185259A3 (es)
JP (1) JPS61140585A (es)
AU (1) AU576924B2 (es)
CA (1) CA1252783A (es)
DE (1) DE3445298A1 (es)
DK (1) DK161327C (es)
ES (1) ES8707238A1 (es)
FI (1) FI82696C (es)
GR (1) GR852996B (es)
IL (1) IL77294A (es)
NO (1) NO161373C (es)
NZ (1) NZ214522A (es)
PH (1) PH24451A (es)
PT (1) PT81650B (es)
ZA (1) ZA859462B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
PL374259A1 (en) * 2001-06-28 2005-10-03 Pliva D.D. Novel heterocyclic compounds as selective bacterial dhfr inhibitors and their uses thereof
DE10202468A1 (de) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridinderivate, Verfahren zu deren Herstellung und ihre Verwendung
CA2534151A1 (en) * 2003-08-29 2005-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
EP1673092B1 (en) * 2003-10-17 2007-08-15 4 Aza Ip Nv Heterocycle-substituted pteridine derivatives and their use in therapy
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
JP2007526323A (ja) * 2004-03-04 2007-09-13 ニューロジェン・コーポレーション アリールアルキルアミノ置換キナゾリン類縁体
DE102004057594A1 (de) * 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057645A1 (de) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057618A1 (de) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
DE102004057595A1 (de) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen
WO2007060404A1 (en) * 2005-11-22 2007-05-31 Kudos Pharmaceuticals Limited PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
RU2445315C2 (ru) * 2005-11-22 2012-03-20 Кудос Фармасьютиклз Лимитед ПРОИЗВОДНЫЕ ПИРИДО-, ПИРАЗО- И ПИРИМИДО-ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
WO2007135026A2 (de) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituierte pteridine als therapeutika
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
EP2057156B1 (en) 2006-08-23 2017-02-01 KuDOS Pharmaceuticals Limited 2-methylmorpholine pyrido-,pyrazo- and pyrimido-pyrimidine derivatives as mtor inhibitors
BRPI0914912A2 (pt) 2008-06-20 2017-06-20 Astrazeneca Ab processo para a preparação de um composto, e de um inibidor de mtor quinase, sal de fumarato, composição farmacêutica, uso de um sal de fumarato, e, métodos para produzir um efeito inibitório mtor, e para produzir um efeito anti-câncer em um animal de sangue quente
DK3321265T3 (da) 2015-03-04 2020-06-08 Gilead Sciences Inc 4,6-diamino-pyrido[3,2-d]pyrimidinforbindelser og deres udnyttelse som modulatorer af toll-lignende receptorer
MA46093A (fr) 2016-09-02 2021-05-19 Gilead Sciences Inc Composés modulateurs du recepteur de type toll
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3159628A (en) * 1962-05-28 1964-12-01 Smith Kline French Lab Pteridine-5-oxide derivatives
DE3323932A1 (de) * 1983-07-02 1985-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-piperazino-pteridine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0185259A3 (de) 1989-03-01
ES549806A0 (es) 1987-07-16
AU5123285A (en) 1986-06-19
DK161327C (da) 1991-12-09
PH24451A (en) 1990-06-25
CA1252783A (en) 1989-04-18
ZA859462B (en) 1987-07-29
PT81650B (pt) 1988-04-21
IL77294A (en) 1989-02-28
DK161327B (da) 1991-06-24
NO854965L (no) 1986-06-13
NZ214522A (en) 1988-07-28
AU576924B2 (en) 1988-09-08
GR852996B (es) 1986-04-16
DK572685D0 (da) 1985-12-11
FI82696B (fi) 1990-12-31
NO161373B (no) 1989-05-02
DE3445298A1 (de) 1986-06-12
EP0185259A2 (de) 1986-06-25
PT81650A (de) 1986-01-01
FI854862A0 (fi) 1985-12-10
JPS61140585A (ja) 1986-06-27
ES8707238A1 (es) 1987-07-16
NO161373C (no) 1989-08-09
FI854862A (fi) 1986-06-13
DK572685A (da) 1986-06-13

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Owner name: DR. KARL THOMAE GESELLSCHAFT MIT