ES8607949A1 - Un procedimiento para preparar un derivado de dihidropiridazinona - Google Patents

Un procedimiento para preparar un derivado de dihidropiridazinona

Info

Publication number
ES8607949A1
ES8607949A1 ES539446A ES539446A ES8607949A1 ES 8607949 A1 ES8607949 A1 ES 8607949A1 ES 539446 A ES539446 A ES 539446A ES 539446 A ES539446 A ES 539446A ES 8607949 A1 ES8607949 A1 ES 8607949A1
Authority
ES
Spain
Prior art keywords
formula
procedure
reaction
dihydropiridazinone
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539446A
Other languages
English (en)
Spanish (es)
Other versions
ES539446A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8607949A1 publication Critical patent/ES8607949A1/es
Publication of ES539446A0 publication Critical patent/ES539446A0/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22Nitrogen and oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Hydrogenated Pyridines (AREA)
ES539446A 1984-01-13 1985-01-10 Un procedimiento para preparar un derivado de dihidropiridazinona Expired ES8607949A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848400863A GB8400863D0 (en) 1984-01-13 1984-01-13 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8607949A1 true ES8607949A1 (es) 1986-06-01
ES539446A0 ES539446A0 (es) 1986-06-01

Family

ID=10554924

Family Applications (3)

Application Number Title Priority Date Filing Date
ES539446A Expired ES8607949A1 (es) 1984-01-13 1985-01-10 Un procedimiento para preparar un derivado de dihidropiridazinona
ES549629A Expired ES8703846A1 (es) 1984-01-13 1985-12-05 Un procedimiento para preparar derivados de dihidropiridazi-nona
ES554965A Expired ES8706645A1 (es) 1984-01-13 1986-05-14 Un procedimiento para preparar derivados de dihidropiridazinona

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES549629A Expired ES8703846A1 (es) 1984-01-13 1985-12-05 Un procedimiento para preparar derivados de dihidropiridazi-nona
ES554965A Expired ES8706645A1 (es) 1984-01-13 1986-05-14 Un procedimiento para preparar derivados de dihidropiridazinona

Country Status (31)

Country Link
US (1) US4654342A (en:Method)
EP (1) EP0150937B1 (en:Method)
JP (3) JPS60158181A (en:Method)
KR (1) KR920006781B1 (en:Method)
CN (1) CN85101722A (en:Method)
AT (1) ATE37179T1 (en:Method)
AU (1) AU572252B2 (en:Method)
CA (2) CA1251209A (en:Method)
CS (1) CS248731B2 (en:Method)
DD (1) DD231350A5 (en:Method)
DE (1) DE3564941D1 (en:Method)
DK (1) DK162519C (en:Method)
ES (3) ES8607949A1 (en:Method)
FI (1) FI850140L (en:Method)
GB (1) GB8400863D0 (en:Method)
GR (1) GR850068B (en:Method)
HU (1) HU193591B (en:Method)
IE (1) IE57969B1 (en:Method)
IL (1) IL74031A (en:Method)
JO (1) JO1351B1 (en:Method)
MY (1) MY100124A (en:Method)
NO (1) NO850129L (en:Method)
NZ (1) NZ210816A (en:Method)
PH (1) PH22136A (en:Method)
PL (1) PL147123B1 (en:Method)
PT (1) PT79819B (en:Method)
RO (1) RO92607A (en:Method)
SU (1) SU1396963A3 (en:Method)
WO (1) WO1985003076A1 (en:Method)
ZA (1) ZA85251B (en:Method)
ZW (1) ZW385A1 (en:Method)

Families Citing this family (35)

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CA1251448A (en) * 1985-03-27 1989-03-21 William J. Coates Pyridazinone derivatives
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
GB8722776D0 (en) * 1987-09-28 1987-11-04 Smith Kline French Lab Chemical compounds
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
EP1377282B1 (en) * 2001-02-27 2006-08-16 MIGENIX Corp. Aryl-n-cyanoguanidines and methods related thereto
JP5116940B2 (ja) * 2001-11-05 2013-01-09 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒドラゾノ−マロニトリル類
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102004011512B4 (de) 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en) * 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) * 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
CN101309685A (zh) * 2005-11-14 2008-11-19 贝林格尔·英格海姆维特梅迪卡有限公司 磷酸二酯酶ⅲ型抑制剂或者钙增敏剂用于治疗无症状(潜隐性)心力衰竭的用途
EP1920785A1 (en) * 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
HRP20131150T1 (hr) 2008-11-25 2014-01-03 Boehringer Ingelheim Vetmedica Gmbh Pimobendan za uporabu u lijeäśenju hipertrofiäśne kardiomiopatije kod maäśaka
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
ES2924478T3 (es) 2012-03-15 2022-10-07 Boehringer Ingelheim Vetmedica Gmbh Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
HK1218629A1 (zh) 2013-02-25 2017-03-03 Bausch Health Ireland Limited 用於结肠清洁的鸟苷酸环化酶受体激动剂
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
ES2860526T3 (es) 2013-07-19 2021-10-05 Boehringer Ingelheim Vetmedica Gmbh Derivados de ciclodextrina eterificada conservados que contienen una composición farmacéutica acuosa líquida
MX375926B (es) 2013-08-09 2025-03-07 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
PL3106150T3 (pl) 2013-12-04 2022-01-03 Boehringer Ingelheim Vetmedica Gmbh Ulepszone kompozycje farmaceutyczne pimobendanu
CN104987310A (zh) * 2015-06-03 2015-10-21 青岛农业大学 左西孟旦的合成工艺
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
BE791539A (fr) * 1971-11-19 1973-05-17 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
DE3063196D1 (en) * 1979-12-05 1983-06-16 Morishita Pharma Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them
DE3263497D1 (en) * 1981-03-04 1985-06-20 Ciba Geigy Ag Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58140076A (ja) * 1982-02-09 1983-08-19 Mitsubishi Chem Ind Ltd ピリダジノン誘導体又はその塩類
DE3204375C2 (de) * 1982-02-09 1983-12-01 J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle Verfahren zur Herabsetzung der Saugfähigkeit von Holz
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones

Also Published As

Publication number Publication date
PL251516A1 (en) 1985-12-17
SU1396963A3 (ru) 1988-05-15
CN85101722A (zh) 1987-01-31
FI850140A0 (fi) 1985-01-11
FI850140A7 (fi) 1985-07-14
JPS63313776A (ja) 1988-12-21
MY100124A (en) 1989-12-18
FI850140L (fi) 1985-07-14
GR850068B (en:Method) 1985-05-03
JPS60158181A (ja) 1985-08-19
EP0150937A3 (en) 1985-08-21
WO1985003076A1 (en) 1985-07-18
CA1251209A (en) 1989-03-14
IE850069L (en) 1985-07-13
RO92607A (ro) 1987-11-30
ZA85251B (en) 1986-08-27
NZ210816A (en) 1987-06-30
KR920006781B1 (ko) 1992-08-17
ZW385A1 (en) 1985-08-07
PL147123B1 (en) 1989-04-29
NO850129L (no) 1985-07-15
ES8703846A1 (es) 1987-03-01
IE57969B1 (en) 1993-06-02
AU572252B2 (en) 1988-05-05
PT79819B (en) 1987-01-07
DD231350A5 (de) 1985-12-24
IL74031A (en) 1988-07-31
AU3761185A (en) 1985-07-18
EP0150937B1 (en) 1988-09-14
GB8400863D0 (en) 1984-02-15
KR850005417A (ko) 1985-08-26
IL74031A0 (en) 1985-04-30
CS248731B2 (en) 1987-02-12
DK162519C (da) 1992-03-30
DK162519B (da) 1991-11-11
ATE37179T1 (de) 1988-09-15
ES539446A0 (es) 1986-06-01
ES554965A0 (es) 1987-07-01
ES8706645A1 (es) 1987-07-01
PH22136A (en) 1988-06-01
DE3564941D1 (en) 1988-10-20
JO1351B1 (en) 1986-11-30
US4654342A (en) 1987-03-31
CA1260471C (en:Method) 1989-09-26
CA1260471A (en) 1989-09-26
EP0150937A2 (en) 1985-08-07
DK9185A (da) 1985-07-14
HU193591B (en) 1987-11-30
ES549629A0 (es) 1987-03-01
DK9185D0 (da) 1985-01-08
JPS63313775A (ja) 1988-12-21
PT79819A (en) 1985-02-01
HUT37128A (en) 1985-11-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401