ES8500325A1 - Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana. - Google Patents

Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.

Info

Publication number
ES8500325A1
ES8500325A1 ES521418A ES521418A ES8500325A1 ES 8500325 A1 ES8500325 A1 ES 8500325A1 ES 521418 A ES521418 A ES 521418A ES 521418 A ES521418 A ES 521418A ES 8500325 A1 ES8500325 A1 ES 8500325A1
Authority
ES
Spain
Prior art keywords
human urokinase
polypeptides
polypeptide
human
urokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521418A
Other languages
English (en)
Spanish (es)
Other versions
ES521418A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES521418A0 publication Critical patent/ES521418A0/es
Publication of ES8500325A1 publication Critical patent/ES8500325A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
ES521418A 1982-04-15 1983-04-13 Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana. Expired ES8500325A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (2)

Publication Number Publication Date
ES521418A0 ES521418A0 (es) 1984-11-01
ES8500325A1 true ES8500325A1 (es) 1984-11-01

Family

ID=27004326

Family Applications (3)

Application Number Title Priority Date Filing Date
ES521418A Expired ES8500325A1 (es) 1982-04-15 1983-04-13 Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.
ES533924A Granted ES533924A0 (es) 1982-04-15 1984-07-02 Procedimiento para preparar proteina de uroquinasa humana bioactiva
ES533925A Expired ES8602121A1 (es) 1982-04-15 1984-07-02 Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES533924A Granted ES533924A0 (es) 1982-04-15 1984-07-02 Procedimiento para preparar proteina de uroquinasa humana bioactiva
ES533925A Expired ES8602121A1 (es) 1982-04-15 1984-07-02 Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana

Country Status (20)

Country Link
EP (2) EP0092182B1 (enExample)
JP (3) JPH0655145B2 (enExample)
AT (2) ATE232237T1 (enExample)
AU (1) AU573523B2 (enExample)
BR (1) BR8301918A (enExample)
CA (1) CA1341301C (enExample)
DE (2) DE3382760T2 (enExample)
DK (1) DK173910B1 (enExample)
ES (3) ES8500325A1 (enExample)
FI (1) FI88932C (enExample)
GR (1) GR78180B (enExample)
HK (1) HK38297A (enExample)
IE (1) IE64536B1 (enExample)
IL (2) IL68366A (enExample)
MY (1) MY102472A (enExample)
NO (1) NO831317L (enExample)
NZ (1) NZ203869A (enExample)
PH (4) PH24783A (enExample)
PT (1) PT76546B (enExample)
YU (1) YU45128B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
DE3585097D1 (de) * 1984-02-27 1992-02-20 Green Cross Corp Herstellung menschlicher urokinase.
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
WO1986004351A1 (fr) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Prourokinase humaine stabilisee
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
EP0330700B1 (en) * 1987-08-19 1993-12-22 Sagami Chemical Research Center Human prourokinase-like polypeptide
DE3887425T2 (de) * 1987-10-02 1994-06-23 Zymogenetics Inc BAR1-Sekretions-Signal-Sequenz.
AU2354588A (en) * 1987-10-09 1989-04-20 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2067821A1 (en) * 1989-10-24 1991-04-25 Cetus Oncology Corporation Infective drug delivery system using recombinant retroviral vectors
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
EP1088081B1 (en) * 1998-06-26 2005-03-09 Croptech Development Corporation Production of urokinase in plant-based expression systems
WO2001097752A2 (en) * 2000-06-20 2001-12-27 The Trustees Of The University Of Pennsylvania Compositions comprising urokinase for modulating muscle contractility and angiogenisis
US20030040095A1 (en) * 2001-03-16 2003-02-27 Achille Arini Method for the production of pharmaceutically active recombinant proteins
NZ595193A (en) 2005-10-21 2013-09-27 Catalyst Biosciences Inc Modified Proteases That Inhibit Complement Activation
TWI369402B (en) 2006-07-05 2012-08-01 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6642281A (en) * 1979-11-13 1981-06-03 Husain, S.S. Isolation of plasminogen activators useful as therapeutic anddiagnostic agents
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren

Also Published As

Publication number Publication date
FI88932B (fi) 1993-04-15
ES8506087A1 (es) 1985-07-01
IE950235L (en) 1983-10-15
PT76546B (en) 1986-03-20
HK38297A (en) 1997-04-04
EP0620279A1 (en) 1994-10-19
ATE112802T1 (de) 1994-10-15
EP0092182A3 (en) 1984-07-18
DK173910B1 (da) 2002-02-11
IL83236A0 (en) 1987-12-31
ES521418A0 (es) 1984-11-01
DK163683D0 (da) 1983-04-14
CA1341301C (en) 2001-10-09
NO831317L (no) 1983-10-17
JPH0824579B2 (ja) 1996-03-13
DE3382760T2 (de) 1995-03-02
DE3382760D1 (de) 1994-11-17
PT76546A (en) 1983-05-01
MY102472A (en) 1992-06-30
IE830850L (en) 1983-10-15
FI88932C (fi) 1993-07-26
ES533925A0 (es) 1985-12-01
JP2584192B2 (ja) 1997-02-19
ES8602121A1 (es) 1985-12-01
GR78180B (enExample) 1984-09-26
YU45128B (en) 1992-03-10
YU86883A (en) 1988-10-31
AU573523B2 (en) 1988-06-16
IL68366A (en) 1990-08-31
IE64536B1 (en) 1995-08-09
JPH07186A (ja) 1995-01-06
DE3382837T2 (de) 2004-01-15
IL68366A0 (en) 1983-07-31
ES533924A0 (es) 1985-07-01
AU1352483A (en) 1983-10-20
DE3382837D1 (de) 2003-03-13
EP0620279B1 (en) 2003-02-05
FI831228L (fi) 1983-10-16
PH25312A (en) 1991-04-30
PH24783A (en) 1990-10-30
FI831228A0 (fi) 1983-04-12
EP0092182B1 (en) 1994-10-12
PH25120A (en) 1991-02-19
DK163683A (da) 1983-11-28
EP0092182A2 (en) 1983-10-26
JPH0530970A (ja) 1993-02-09
JPS5951300A (ja) 1984-03-24
NZ203869A (en) 1987-04-30
PH22461A (en) 1988-09-12
JPH0655145B2 (ja) 1994-07-27
BR8301918A (pt) 1983-12-20
ATE232237T1 (de) 2003-02-15

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