ES533925A0 - Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana - Google Patents

Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana

Info

Publication number
ES533925A0
ES533925A0 ES533925A ES533925A ES533925A0 ES 533925 A0 ES533925 A0 ES 533925A0 ES 533925 A ES533925 A ES 533925A ES 533925 A ES533925 A ES 533925A ES 533925 A0 ES533925 A0 ES 533925A0
Authority
ES
Spain
Prior art keywords
procedure
formation
produce
expression vehicle
human urokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES533925A
Other languages
English (en)
Other versions
ES8602121A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES533925A0 publication Critical patent/ES533925A0/es
Publication of ES8602121A1 publication Critical patent/ES8602121A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
ES533925A 1982-04-15 1984-07-02 Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana Expired ES8602121A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (2)

Publication Number Publication Date
ES533925A0 true ES533925A0 (es) 1985-12-01
ES8602121A1 ES8602121A1 (es) 1985-12-01

Family

ID=27004326

Family Applications (3)

Application Number Title Priority Date Filing Date
ES521418A Expired ES8500325A1 (es) 1982-04-15 1983-04-13 Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.
ES533924A Expired ES8506087A1 (es) 1982-04-15 1984-07-02 Procedimiento para preparar proteina de uroquinasa humana bioactiva
ES533925A Expired ES8602121A1 (es) 1982-04-15 1984-07-02 Procedimiento para producir un vehiculo de expresion para la formacion de uroquinasa humana

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES521418A Expired ES8500325A1 (es) 1982-04-15 1983-04-13 Procedimiento para la preparacion de proteinas funcionales de uroquinasa humana.
ES533924A Expired ES8506087A1 (es) 1982-04-15 1984-07-02 Procedimiento para preparar proteina de uroquinasa humana bioactiva

Country Status (20)

Country Link
EP (2) EP0620279B1 (es)
JP (3) JPH0655145B2 (es)
AT (2) ATE112802T1 (es)
AU (1) AU573523B2 (es)
BR (1) BR8301918A (es)
CA (1) CA1341301C (es)
DE (2) DE3382760T2 (es)
DK (1) DK173910B1 (es)
ES (3) ES8500325A1 (es)
FI (1) FI88932C (es)
GR (1) GR78180B (es)
HK (1) HK38297A (es)
IE (1) IE64536B1 (es)
IL (2) IL68366A (es)
MY (1) MY102472A (es)
NO (1) NO831317L (es)
NZ (1) NZ203869A (es)
PH (4) PH24783A (es)
PT (1) PT76546B (es)
YU (1) YU45128B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
DE3486023T2 (de) * 1983-09-13 1993-06-24 Green Cross Corp Verfahren zur herstellung von urokinase zymogen.
EP0154272B1 (en) * 1984-02-27 1992-01-08 Green Cross Corporation Production of human urokinase
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
WO1986004351A1 (en) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Stabilized human prourokinase
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
WO1989001513A1 (en) * 1987-08-19 1989-02-23 Sagami Chemical Research Center Fast-acting prourokinase
JP2730923B2 (ja) * 1987-10-02 1998-03-25 ザイモジェネティクス，インコーポレイティド Ｂａｒ１分泌シグナル
EP0316068A1 (en) * 1987-10-09 1989-05-17 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2067821A1 (en) * 1989-10-24 1991-04-25 Cetus Oncology Corporation Infective drug delivery system using recombinant retroviral vectors
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
AU4714799A (en) * 1998-06-26 2000-01-17 Croptech Development Corporation Production of urokinase in plant-based expression systems
WO2001097752A2 (en) * 2000-06-20 2001-12-27 The Trustees Of The University Of Pennsylvania Compositions comprising urokinase for modulating muscle contractility and angiogenisis
NZ595193A (en) * 2005-10-21 2013-09-27 Catalyst Biosciences Inc Modified Proteases That Inhibit Complement Activation
SG175602A1 (en) 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1382A (en) * 1979-11-13 1987-12-18 Syed Shaukat Husain Isolation of plasminogen activators useful as therapeutic and diagnostic agents
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
DD229151A5 (de) * 1983-11-21 1985-10-30 Ciba Geigy Ag Verfahren zur herstellung von gewebeplasminogenaktivatoren

Also Published As

Publication number Publication date
JPH0530970A (ja) 1993-02-09
IL68366A (en) 1990-08-31
EP0092182A2 (en) 1983-10-26
DE3382837T2 (de) 2004-01-15
DE3382760D1 (de) 1994-11-17
PT76546A (en) 1983-05-01
ATE112802T1 (de) 1994-10-15
DK173910B1 (da) 2002-02-11
FI831228A0 (fi) 1983-04-12
DE3382837D1 (de) 2003-03-13
ES8602121A1 (es) 1985-12-01
BR8301918A (pt) 1983-12-20
EP0620279A1 (en) 1994-10-19
CA1341301C (en) 2001-10-09
ATE232237T1 (de) 2003-02-15
GR78180B (es) 1984-09-26
PH25120A (en) 1991-02-19
ES521418A0 (es) 1984-11-01
NZ203869A (en) 1987-04-30
DE3382760T2 (de) 1995-03-02
IL83236A0 (en) 1987-12-31
JPH0655145B2 (ja) 1994-07-27
JP2584192B2 (ja) 1997-02-19
JPH07186A (ja) 1995-01-06
JPH0824579B2 (ja) 1996-03-13
IE64536B1 (en) 1995-08-09
ES8500325A1 (es) 1984-11-01
FI88932B (fi) 1993-04-15
EP0092182B1 (en) 1994-10-12
EP0620279B1 (en) 2003-02-05
YU86883A (en) 1988-10-31
YU45128B (en) 1992-03-10
EP0092182A3 (en) 1984-07-18
DK163683D0 (da) 1983-04-14
AU1352483A (en) 1983-10-20
PH22461A (en) 1988-09-12
DK163683A (da) 1983-11-28
PH25312A (en) 1991-04-30
HK38297A (en) 1997-04-04
FI88932C (fi) 1993-07-26
JPS5951300A (ja) 1984-03-24
IE950235L (en) 1983-10-15
FI831228L (fi) 1983-10-16
ES533924A0 (es) 1985-07-01
PH24783A (en) 1990-10-30
PT76546B (en) 1986-03-20
ES8506087A1 (es) 1985-07-01
IE830850L (en) 1983-10-15
IL68366A0 (en) 1983-07-31
NO831317L (no) 1983-10-17
MY102472A (en) 1992-06-30
AU573523B2 (en) 1988-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050910