ES2132232T3 - Produccion de lactoferrina humana recombinante. - Google Patents
Produccion de lactoferrina humana recombinante.Info
- Publication number
- ES2132232T3 ES2132232T3 ES93912287T ES93912287T ES2132232T3 ES 2132232 T3 ES2132232 T3 ES 2132232T3 ES 93912287 T ES93912287 T ES 93912287T ES 93912287 T ES93912287 T ES 93912287T ES 2132232 T3 ES2132232 T3 ES 2132232T3
- Authority
- ES
- Spain
- Prior art keywords
- human lactoferrin
- recombinant human
- production
- lactoferrin protein
- lactoferrin production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
LA PRESENTE INVENCION PROVEE NUEVAS CELULAS EUCARIOCAS TRANSFECTADAS, PLASMIDAS Y LOS METODOS PARA PRODUCIR ESAS PLASMIDAS Y LAS CELULAS EUCARIOTICAS TRANSFECTADAS. LA NUEVA PLASMIDA CONTIENE EL CDNA PARA LA PROTEINA LACTOFERRINA HUMANA. ESTAN PREVISTOS TAMBIEN LOS METODOS PARA LA PRODUCCION DE LA PROTEINA LACTOFERRINA HUMANA EN A.ORYZAE. ASI, LA PRESENTE INVENCION PROVEE UNOS MEDIOS EFICIENTES Y ECONOMICOS PARA LA PRODUCCION DE LA PROTEINA LACTOFERRINA HUMANA RECOMBINANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87330492A | 1992-04-24 | 1992-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2132232T3 true ES2132232T3 (es) | 1999-08-16 |
Family
ID=25361366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93912287T Expired - Lifetime ES2132232T3 (es) | 1992-04-24 | 1993-04-16 | Produccion de lactoferrina humana recombinante. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5571896A (es) |
EP (1) | EP0644899B1 (es) |
JP (1) | JP2824332B2 (es) |
KR (2) | KR0184693B1 (es) |
CN (2) | CN1047204C (es) |
AT (1) | ATE177473T1 (es) |
AU (1) | AU681583B2 (es) |
BR (1) | BR9306289A (es) |
CA (1) | CA2134094C (es) |
DE (1) | DE69323879T2 (es) |
DK (1) | DK0644899T3 (es) |
ES (1) | ES2132232T3 (es) |
GR (1) | GR3029942T3 (es) |
HK (1) | HK1027360A1 (es) |
IL (1) | IL105400A (es) |
NZ (1) | NZ252844A (es) |
SG (1) | SG47605A1 (es) |
WO (1) | WO1993022348A1 (es) |
ZA (1) | ZA932568B (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
US6066469A (en) * | 1990-03-08 | 2000-05-23 | Ferro Dynamics, Inc. | Cloning, expression, and uses of human lactoferrin |
JP3529423B2 (ja) * | 1994-04-01 | 2004-05-24 | 森永乳業株式会社 | 抗菌性ペプチドの製造方法 |
FR2735983B1 (fr) | 1995-06-29 | 1997-12-05 | Centre Nat Rech Scient | Peptide permettant de modifier l'activite du systeme immunitaire humain ou animal |
DE19540233B4 (de) * | 1995-10-19 | 2005-08-25 | Schering Ag | Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
US6111081A (en) * | 1996-05-31 | 2000-08-29 | Baylor College Of Medicine | Lactoferrin variants and uses thereof |
WO1998033509A2 (en) * | 1997-02-03 | 1998-08-06 | Pharming Intellectual Property Bv | Useful properties of human lactoferrin and variants thereof |
WO2000004132A1 (en) * | 1998-07-15 | 2000-01-27 | Samyang Genex Corporation | Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof |
US6423509B1 (en) | 1998-07-15 | 2002-07-23 | Samyang Genex Corporation | Pichia pastoris strain for producing lactoferrin and methods of use |
US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
AU7042000A (en) * | 1999-10-19 | 2001-05-14 | Easy Bio System, Inc. | Recombinant yeast strain for expressing human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin and process for preparation recombinant human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin using the same |
US20080050503A1 (en) * | 2000-05-02 | 2008-02-28 | Ning Huang | Expression of human milk proteins in transgenic plants |
US7417178B2 (en) * | 2000-05-02 | 2008-08-26 | Ventria Bioscience | Expression of human milk proteins in transgenic plants |
US7138150B2 (en) * | 2000-05-02 | 2006-11-21 | Ventria Bioscience | Method of making an anti-infective composition for treating oral infections |
US8129504B2 (en) | 2001-08-30 | 2012-03-06 | Biorexis Technology, Inc. | Oral delivery of modified transferrin fusion proteins |
US20070031440A1 (en) * | 2001-08-30 | 2007-02-08 | Prior Christopher P | Modified transferin-antibody fusion proteins |
US7176278B2 (en) * | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
EP1427750B1 (en) * | 2001-08-30 | 2010-12-08 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
EP1478379A4 (en) * | 2001-12-28 | 2005-12-21 | Campina Bv | HUMANIZED LACTOFERRIN AND ITS APPLICATIONS |
WO2003094952A1 (en) * | 2002-05-10 | 2003-11-20 | Agennix Incorporated | Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
AU2003233583A1 (en) * | 2002-05-24 | 2003-12-12 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
US20060105387A1 (en) * | 2002-08-30 | 2006-05-18 | Prior Christopher P | Transferrin fusion proteins libraries |
US20060130158A1 (en) * | 2002-08-30 | 2006-06-15 | Turner Andrew J | Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains |
WO2004024180A1 (en) | 2002-09-16 | 2004-03-25 | Agennix Incorporated | Lactoferrin compositions and methods of wound treatment |
AU2003298906A1 (en) * | 2002-12-06 | 2004-06-30 | Agennix Incorporated | Oral lactoferrin in the treatment of sepsis |
AU2003296447A1 (en) * | 2002-12-10 | 2004-06-30 | Agennix Incorporated | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
US20070060512A1 (en) * | 2003-03-04 | 2007-03-15 | Homayoun Sadeghi | Dipeptidyl-peptidase protected protein |
KR100468596B1 (ko) * | 2003-04-04 | 2005-01-27 | (주) 디지탈바이오텍 | 메탄올자화효모인 피치아 패스토리스를 이용하여 인간락토페린을 생산하는 방법, 이 방법에 의해 제조된 인간락토페린 및 피치아 패스토리스 균주 |
US7379700B2 (en) * | 2003-05-06 | 2008-05-27 | Canon Kabushiki Kaisha | Image reading apparatus with rotatable internal and external guides |
WO2005046571A2 (en) * | 2003-06-06 | 2005-05-26 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
US20040259770A1 (en) * | 2003-06-19 | 2004-12-23 | Rush University Medical Center | Method for determining leukocyte activation |
US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
EP1663278A4 (en) * | 2003-08-28 | 2009-07-29 | Biorexis Pharmaceutical Corp | EPO MIMETIC PEPTIDES AND FUSION PROTEINS |
US20060205037A1 (en) * | 2003-08-28 | 2006-09-14 | Homayoun Sadeghi | Modified transferrin fusion proteins |
GB0329722D0 (en) * | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
US7125963B2 (en) * | 2004-03-03 | 2006-10-24 | En N Tech Inc | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions |
WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
DK2330200T3 (en) | 2004-12-23 | 2017-07-24 | Albumedix As | GENE EXPRESSION TECHNIQUE |
WO2007150049A2 (en) | 2006-06-22 | 2007-12-27 | Agennix Incorporated | Lactoferrin as a radioprotective agent |
CA2658654A1 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
NZ555163A (en) | 2007-05-14 | 2010-05-28 | Fonterra Co Operative Group | Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments |
NZ583234A (en) | 2007-07-10 | 2012-06-29 | Glanbia Nutritionals | Method for removing endotoxin from proteins |
WO2011104352A1 (en) | 2010-02-25 | 2011-09-01 | Agennix Ag | Oral lactoferrin in the treatment of severe sepsis |
EP2851421B1 (en) | 2012-07-03 | 2018-11-28 | Kao Corporation | Useful microorganism, and method for producing substance of interest |
KR20210091206A (ko) * | 2018-11-06 | 2021-07-21 | 아르헬 프로젝티랜제 인 인제나이어링 디.오.오. | 우유, 초유 및 산 또는 스위트 유청으로부터 고도로 정제된 락토페린 및 락토퍼옥시다제를 제조하는 방법 |
KR200494603Y1 (ko) | 2019-12-09 | 2021-11-12 | 한국청소년활동진흥원 | 타워형 구조를 이루는 기술 융합형 조립 교구 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
US4935349A (en) * | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
DK122686D0 (da) * | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
AU619458B2 (en) * | 1987-01-30 | 1992-01-30 | Board Of Trustees Of The Leland Stanford Junior University | Lymphocyte inhibition by hla peptides |
WO1989001969A1 (en) * | 1987-09-04 | 1989-03-09 | Novo-Nordisk A/S | Process for the production of protein products in aspergillus and promoters for use in aspergillus |
IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
US5155037A (en) * | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
WO1991013982A1 (en) * | 1990-03-08 | 1991-09-19 | Ferrodynamics, Inc. | Genetically engineered human lactoferrin |
JP2818056B2 (ja) * | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
-
1993
- 1993-04-13 ZA ZA932568A patent/ZA932568B/xx unknown
- 1993-04-15 IL IL10540093A patent/IL105400A/xx not_active IP Right Cessation
- 1993-04-16 BR BR9306289A patent/BR9306289A/pt not_active Application Discontinuation
- 1993-04-16 CA CA002134094A patent/CA2134094C/en not_active Expired - Lifetime
- 1993-04-16 EP EP93912287A patent/EP0644899B1/en not_active Expired - Lifetime
- 1993-04-16 JP JP5519314A patent/JP2824332B2/ja not_active Expired - Lifetime
- 1993-04-16 SG SG1996003100A patent/SG47605A1/en unknown
- 1993-04-16 DE DE69323879T patent/DE69323879T2/de not_active Expired - Lifetime
- 1993-04-16 AT AT93912287T patent/ATE177473T1/de active
- 1993-04-16 NZ NZ252844A patent/NZ252844A/en not_active IP Right Cessation
- 1993-04-16 WO PCT/US1993/003614 patent/WO1993022348A1/en active IP Right Grant
- 1993-04-16 AU AU42892/93A patent/AU681583B2/en not_active Expired
- 1993-04-16 DK DK93912287T patent/DK0644899T3/da active
- 1993-04-16 KR KR1019940703776A patent/KR0184693B1/ko not_active IP Right Cessation
- 1993-04-16 ES ES93912287T patent/ES2132232T3/es not_active Expired - Lifetime
- 1993-04-24 CN CN93105290A patent/CN1047204C/zh not_active Expired - Lifetime
- 1993-04-24 CN CNB991086597A patent/CN1161382C/zh not_active Expired - Lifetime
-
1994
- 1994-05-27 US US08/250,308 patent/US5571896A/en not_active Expired - Lifetime
-
1998
- 1998-09-10 KR KR1019980707113A patent/KR100221404B1/ko not_active IP Right Cessation
-
1999
- 1999-04-13 GR GR990401031T patent/GR3029942T3/el unknown
-
2000
- 2000-10-11 HK HK00106450A patent/HK1027360A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69323879T2 (de) | 1999-11-04 |
CN1250055A (zh) | 2000-04-12 |
KR100221404B1 (en) | 1999-10-01 |
AU681583B2 (en) | 1997-09-04 |
JP2824332B2 (ja) | 1998-11-11 |
SG47605A1 (en) | 1998-04-17 |
DE69323879D1 (de) | 1999-04-15 |
WO1993022348A1 (en) | 1993-11-11 |
US5571896A (en) | 1996-11-05 |
ZA932568B (en) | 1993-11-12 |
AU4289293A (en) | 1993-11-29 |
CA2134094C (en) | 2004-01-06 |
NZ252844A (en) | 1996-05-28 |
EP0644899A4 (en) | 1996-06-26 |
JPH08504561A (ja) | 1996-05-21 |
IL105400A (en) | 2003-03-12 |
CN1047204C (zh) | 1999-12-08 |
ATE177473T1 (de) | 1999-03-15 |
CA2134094A1 (en) | 1993-11-11 |
DK0644899T3 (da) | 1999-09-27 |
KR0184693B1 (ko) | 1999-04-01 |
KR950701348A (ko) | 1995-03-23 |
EP0644899A1 (en) | 1995-03-29 |
CN1079780A (zh) | 1993-12-22 |
HK1027360A1 (en) | 2001-01-12 |
BR9306289A (pt) | 1998-06-30 |
GR3029942T3 (en) | 1999-07-30 |
EP0644899B1 (en) | 1999-03-10 |
CN1161382C (zh) | 2004-08-11 |
IL105400A0 (en) | 1993-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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