IL83236A0 - Preparation of functional human urokinase proteins - Google Patents

Preparation of functional human urokinase proteins

Info

Publication number
IL83236A0
IL83236A0 IL83236A IL8323687A IL83236A0 IL 83236 A0 IL83236 A0 IL 83236A0 IL 83236 A IL83236 A IL 83236A IL 8323687 A IL8323687 A IL 8323687A IL 83236 A0 IL83236 A0 IL 83236A0
Authority
IL
Israel
Prior art keywords
preparation
functional human
human urokinase
proteins
urokinase proteins
Prior art date
Application number
IL83236A
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to IL83236A priority Critical patent/IL83236A0/en
Publication of IL83236A0 publication Critical patent/IL83236A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel derivatives of the human protein urokinase are disclosed together with methods of making them using recombinant DNA technology.
IL83236A 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins IL83236A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14
IL68366A IL68366A (en) 1982-04-15 1983-04-12 Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Publications (1)

Publication Number Publication Date
IL83236A0 true IL83236A0 (en) 1987-12-31

Family

ID=27004326

Family Applications (2)

Application Number Title Priority Date Filing Date
IL68366A IL68366A (en) 1982-04-15 1983-04-12 Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL68366A IL68366A (en) 1982-04-15 1983-04-12 Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture

Country Status (20)

Country Link
EP (2) EP0092182B1 (en)
JP (3) JPH0655145B2 (en)
AT (2) ATE112802T1 (en)
AU (1) AU573523B2 (en)
BR (1) BR8301918A (en)
CA (1) CA1341301C (en)
DE (2) DE3382760T2 (en)
DK (1) DK173910B1 (en)
ES (3) ES8500325A1 (en)
FI (1) FI88932C (en)
GR (1) GR78180B (en)
HK (1) HK38297A (en)
IE (1) IE64536B1 (en)
IL (2) IL68366A (en)
MY (1) MY102472A (en)
NO (1) NO831317L (en)
NZ (1) NZ203869A (en)
PH (4) PH24783A (en)
PT (1) PT76546B (en)
YU (1) YU45128B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
NZ208612A (en) * 1983-06-24 1991-09-25 Genentech Inc Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen
JPS61177987A (en) * 1985-01-31 1986-08-09 Green Cross Corp:The Production of human urokinase
JPS60180591A (en) * 1984-02-27 1985-09-14 Green Cross Corp:The Dna sequence, plasmid and host of human urokinase
DE3585097D1 (en) * 1984-02-27 1992-02-20 Green Cross Corp PRODUCTION OF HUMAN UROKINASE.
JPS61181377A (en) * 1985-01-25 1986-08-14 Sagami Chem Res Center Human urokinase gene
WO1986004351A1 (en) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Stabilized human prourokinase
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (en) * 1985-12-25 1987-07-03 Green Cross Corp:The Production of physiologically active substance
DE3613401A1 (en) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh METHOD FOR PRODUCING PLASMINOGEN ACTIVATORS IN PROKARYONTS
NL8601240A (en) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw PLASMINOGEN ACTIVATOR AND THROMBOLYTIC MEDICINAL PRODUCT.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (en) * 1986-10-23 1988-05-10 Green Cross Corp:The Production of human urokinase
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
AU1295088A (en) * 1987-01-30 1988-08-24 American Home Products Corporation Des-epidermal growth factor plasminogen activators
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
DE3886517T2 (en) * 1987-08-19 1994-04-21 Sagami Chem Res Human prourokinase-like polypeptide.
CA1314830C (en) * 1987-10-02 1993-03-23 Susan K. Welch Bar1 secretion signal
JPH02438A (en) * 1987-10-09 1990-01-05 Collaborative Res Inc Modified low molecular weight plasminogen activated factor and production thereof
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
ATE199398T1 (en) * 1989-10-24 2001-03-15 Chiron Corp SECRETION OF HUMAN PROTEIN BONDED WITH GAMMA INTERFERON SIGNAL PEPTIDE
DE4101736A1 (en) 1991-01-22 1992-07-23 Gruenenthal Gmbh NEW PLASMINOGENACTIVATORS USEFUL POLYPEPTIDES, DAFUER CODING PLASMIDS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
DE69924110D1 (en) * 1998-06-26 2005-04-14 Croptech Dev Corp Production of urokinase in plant expression systems
AU2001269803A1 (en) 2000-06-20 2002-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
AU2006304804B2 (en) * 2005-10-21 2011-06-02 Vertex Pharmaceuticals Incorporated Modified proteases that inhibit complement activation
SG175602A1 (en) 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6642281A (en) * 1979-11-13 1981-06-03 Husain, S.S. Isolation of plasminogen activators useful as therapeutic anddiagnostic agents
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
PH22337A (en) * 1983-11-21 1988-08-12 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast

Also Published As

Publication number Publication date
ES8602121A1 (en) 1985-12-01
DK163683D0 (en) 1983-04-14
ATE232237T1 (en) 2003-02-15
IE64536B1 (en) 1995-08-09
EP0620279B1 (en) 2003-02-05
EP0620279A1 (en) 1994-10-19
NZ203869A (en) 1987-04-30
HK38297A (en) 1997-04-04
EP0092182B1 (en) 1994-10-12
IL68366A0 (en) 1983-07-31
JP2584192B2 (en) 1997-02-19
BR8301918A (en) 1983-12-20
JPS5951300A (en) 1984-03-24
YU45128B (en) 1992-03-10
PH24783A (en) 1990-10-30
JPH07186A (en) 1995-01-06
AU573523B2 (en) 1988-06-16
YU86883A (en) 1988-10-31
PH22461A (en) 1988-09-12
DE3382760D1 (en) 1994-11-17
FI831228L (en) 1983-10-16
CA1341301C (en) 2001-10-09
MY102472A (en) 1992-06-30
IE830850L (en) 1983-10-15
ES533924A0 (en) 1985-07-01
JPH0530970A (en) 1993-02-09
ES521418A0 (en) 1984-11-01
AU1352483A (en) 1983-10-20
PH25312A (en) 1991-04-30
DE3382760T2 (en) 1995-03-02
DE3382837D1 (en) 2003-03-13
DK173910B1 (en) 2002-02-11
GR78180B (en) 1984-09-26
IL68366A (en) 1990-08-31
EP0092182A3 (en) 1984-07-18
JPH0824579B2 (en) 1996-03-13
NO831317L (en) 1983-10-17
PT76546B (en) 1986-03-20
ES8506087A1 (en) 1985-07-01
DK163683A (en) 1983-11-28
IE950235L (en) 1983-10-15
FI88932B (en) 1993-04-15
FI831228A0 (en) 1983-04-12
PT76546A (en) 1983-05-01
JPH0655145B2 (en) 1994-07-27
ES533925A0 (en) 1985-12-01
FI88932C (en) 1993-07-26
ES8500325A1 (en) 1984-11-01
PH25120A (en) 1991-02-19
DE3382837T2 (en) 2004-01-15
EP0092182A2 (en) 1983-10-26
ATE112802T1 (en) 1994-10-15

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