ATE112802T1 - Herstellung von funktionellen menschlichen urokinasepolypeptiden. - Google Patents

Herstellung von funktionellen menschlichen urokinasepolypeptiden.

Info

Publication number
ATE112802T1
ATE112802T1 AT83103629T AT83103629T ATE112802T1 AT E112802 T1 ATE112802 T1 AT E112802T1 AT 83103629 T AT83103629 T AT 83103629T AT 83103629 T AT83103629 T AT 83103629T AT E112802 T1 ATE112802 T1 AT E112802T1
Authority
AT
Austria
Prior art keywords
urokinasepolypeptides
production
functional human
human
making
Prior art date
Application number
AT83103629T
Other languages
English (en)
Inventor
Herbert Louis Heyneker
William Evans Holmes
Gordon Alan Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE112802T1 publication Critical patent/ATE112802T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT83103629T 1982-04-15 1983-04-14 Herstellung von funktionellen menschlichen urokinasepolypeptiden. ATE112802T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (1)

Publication Number Publication Date
ATE112802T1 true ATE112802T1 (de) 1994-10-15

Family

ID=27004326

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94104777T ATE232237T1 (de) 1982-04-15 1983-04-14 Herstellung von funktionellen, menschlichen urokinaseproteinen
AT83103629T ATE112802T1 (de) 1982-04-15 1983-04-14 Herstellung von funktionellen menschlichen urokinasepolypeptiden.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94104777T ATE232237T1 (de) 1982-04-15 1983-04-14 Herstellung von funktionellen, menschlichen urokinaseproteinen

Country Status (20)

Country Link
EP (2) EP0620279B1 (de)
JP (3) JPH0655145B2 (de)
AT (2) ATE232237T1 (de)
AU (1) AU573523B2 (de)
BR (1) BR8301918A (de)
CA (1) CA1341301C (de)
DE (2) DE3382760T2 (de)
DK (1) DK173910B1 (de)
ES (3) ES8500325A1 (de)
FI (1) FI88932C (de)
GR (1) GR78180B (de)
HK (1) HK38297A (de)
IE (1) IE64536B1 (de)
IL (2) IL68366A (de)
MY (1) MY102472A (de)
NO (1) NO831317L (de)
NZ (1) NZ203869A (de)
PH (4) PH24783A (de)
PT (1) PT76546B (de)
YU (1) YU45128B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
DE3486023T2 (de) * 1983-09-13 1993-06-24 Green Cross Corp Verfahren zur herstellung von urokinase zymogen.
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
EP0154272B1 (de) * 1984-02-27 1992-01-08 Green Cross Corporation Herstellung menschlicher Urokinase
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
EP0210279B1 (de) * 1985-01-25 1991-08-14 Sagami Chemical Research Center Stabilisierte menschliche prourokinase
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
DE3886517T2 (de) * 1987-08-19 1994-04-21 Sagami Chem Res Menschlicher Prourokinase ähnliches Polypeptid.
CA1314830C (en) * 1987-10-02 1993-03-23 Susan K. Welch Bar1 secretion signal
AU2354588A (en) * 1987-10-09 1989-04-20 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
EP0897987B1 (de) * 1989-10-24 2001-02-28 Chiron Corporation Sekretion vom mit Gamma-Interferon Signalpeptid gebundenen humänen Protein
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
JP2003525578A (ja) * 1998-06-26 2003-09-02 クロプテック・デヴェロップメント・コーポレイション 植物ベースの発現システムにおけるウロキナーゼの製造
AU2001269803A1 (en) 2000-06-20 2002-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
CA2626356C (en) 2005-10-21 2017-08-22 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
JP4546578B2 (ja) 2006-07-05 2010-09-15 カタリスト・バイオサイエンシーズ・インコーポレイテッド プロテアーゼスクリーニング方法およびそれにより同定されるプロテアーゼ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0734743B2 (ja) * 1979-11-13 1995-04-19 バスキユラー・ラボラトリー・インコーポレーテツド プラスミノーゲン活性化剤
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
GR80966B (en) * 1983-11-21 1985-03-15 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast

Also Published As

Publication number Publication date
EP0092182A3 (en) 1984-07-18
AU1352483A (en) 1983-10-20
FI831228A0 (fi) 1983-04-12
IE64536B1 (en) 1995-08-09
FI88932C (fi) 1993-07-26
JPH0655145B2 (ja) 1994-07-27
DK163683D0 (da) 1983-04-14
EP0620279B1 (de) 2003-02-05
PH24783A (en) 1990-10-30
DK173910B1 (da) 2002-02-11
MY102472A (en) 1992-06-30
IL68366A (en) 1990-08-31
EP0092182B1 (de) 1994-10-12
ES521418A0 (es) 1984-11-01
DE3382760D1 (de) 1994-11-17
FI831228L (fi) 1983-10-16
JPH0824579B2 (ja) 1996-03-13
DE3382760T2 (de) 1995-03-02
DK163683A (da) 1983-11-28
JPH07186A (ja) 1995-01-06
JPS5951300A (ja) 1984-03-24
PH25312A (en) 1991-04-30
IL83236A0 (en) 1987-12-31
IL68366A0 (en) 1983-07-31
NO831317L (no) 1983-10-17
EP0620279A1 (de) 1994-10-19
ATE232237T1 (de) 2003-02-15
CA1341301C (en) 2001-10-09
GR78180B (de) 1984-09-26
PH22461A (en) 1988-09-12
IE950235L (en) 1983-10-15
HK38297A (en) 1997-04-04
JPH0530970A (ja) 1993-02-09
YU86883A (en) 1988-10-31
PT76546B (en) 1986-03-20
NZ203869A (en) 1987-04-30
ES8500325A1 (es) 1984-11-01
BR8301918A (pt) 1983-12-20
DE3382837T2 (de) 2004-01-15
YU45128B (en) 1992-03-10
AU573523B2 (en) 1988-06-16
ES8506087A1 (es) 1985-07-01
EP0092182A2 (de) 1983-10-26
ES8602121A1 (es) 1985-12-01
FI88932B (fi) 1993-04-15
JP2584192B2 (ja) 1997-02-19
DE3382837D1 (de) 2003-03-13
ES533924A0 (es) 1985-07-01
IE830850L (en) 1983-10-15
ES533925A0 (es) 1985-12-01
PH25120A (en) 1991-02-19
PT76546A (en) 1983-05-01

Similar Documents

Publication Publication Date Title
ATE112802T1 (de) Herstellung von funktionellen menschlichen urokinasepolypeptiden.
DE3583940D1 (de) Herstellung von streptavidinaehnlichen polypeptiden.
DK371087A (da) Mamalialt interleukin-4
ATE72660T1 (de) Herstellung von zeolith-l.
DE69022595T2 (de) Herstellung von kohlefaser-halbfabrikaten.
ATE71658T1 (de) Verfahren zur herstellung von humanlysozym.
DE3876769D1 (de) Mikrobiologische herstellung von 9-alpha-hydroxy-17-keto-steroiden.
DE3875281T2 (de) Herstellung von pseudoiononen.
DE3585097D1 (de) Herstellung menschlicher urokinase.
DE3670063D1 (de) Herstellung von thioantimonaten.
ATE83800T1 (de) Rekombinantes dns-plasmid zur herstellung von xanthangummi.
ATE66691T1 (de) Herstellung von streptavidinaehnlichen polypeptiden.
ATE62471T1 (de) Herstellung von hydroxyaraldehyden.
ATE51604T1 (de) Herstellung von thioantimonaten.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time