PH24783A - Preparation of functional human urokinase proteins - Google Patents

Preparation of functional human urokinase proteins

Info

Publication number
PH24783A
PH24783A PH28772A PH28772A PH24783A PH 24783 A PH24783 A PH 24783A PH 28772 A PH28772 A PH 28772A PH 28772 A PH28772 A PH 28772A PH 24783 A PH24783 A PH 24783A
Authority
PH
Philippines
Prior art keywords
preparation
functional human
human urokinase
proteins
urokinase proteins
Prior art date
Application number
PH28772A
Other languages
English (en)
Inventor
Herbert L Heyneker
William E Holmes
Gordon A Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PH24783A publication Critical patent/PH24783A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
PH28772A 1982-04-15 1983-04-13 Preparation of functional human urokinase proteins PH24783A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (1)

Publication Number Publication Date
PH24783A true PH24783A (en) 1990-10-30

Family

ID=27004326

Family Applications (4)

Application Number Title Priority Date Filing Date
PH28772A PH24783A (en) 1982-04-15 1983-04-13 Preparation of functional human urokinase proteins
PH31024A PH25312A (en) 1982-04-15 1984-07-24 Preparation of functional human urokinase proteins
PH31025A PH25120A (en) 1982-04-15 1984-07-24 Replicable expression vehicle and process of preparation thereof
PH31022A PH22461A (en) 1982-04-15 1984-07-24 Preparation of functional human urokinase protein

Family Applications After (3)

Application Number Title Priority Date Filing Date
PH31024A PH25312A (en) 1982-04-15 1984-07-24 Preparation of functional human urokinase proteins
PH31025A PH25120A (en) 1982-04-15 1984-07-24 Replicable expression vehicle and process of preparation thereof
PH31022A PH22461A (en) 1982-04-15 1984-07-24 Preparation of functional human urokinase protein

Country Status (20)

Country Link
EP (2) EP0092182B1 (de)
JP (3) JPH0655145B2 (de)
AT (2) ATE232237T1 (de)
AU (1) AU573523B2 (de)
BR (1) BR8301918A (de)
CA (1) CA1341301C (de)
DE (2) DE3382837T2 (de)
DK (1) DK173910B1 (de)
ES (3) ES521418A0 (de)
FI (1) FI88932C (de)
GR (1) GR78180B (de)
HK (1) HK38297A (de)
IE (1) IE64536B1 (de)
IL (2) IL68366A (de)
MY (1) MY102472A (de)
NO (1) NO831317L (de)
NZ (1) NZ203869A (de)
PH (4) PH24783A (de)
PT (1) PT76546B (de)
YU (1) YU45128B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
EP0139447B1 (de) * 1983-09-13 1992-12-30 The Green Cross Corporation Verfahren zur Herstellung von Urokinase Zymogen
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
EP0154272B1 (de) * 1984-02-27 1992-01-08 Green Cross Corporation Herstellung menschlicher Urokinase
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
WO1986004351A1 (en) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Stabilized human prourokinase
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
IE880255L (en) * 1987-01-30 1988-07-30 American Home Prod Des-epidermal growth factor activators.
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
WO1989001513A1 (en) * 1987-08-19 1989-02-23 Sagami Chemical Research Center Fast-acting prourokinase
CA1314830C (en) * 1987-10-02 1993-03-23 Susan K. Welch Bar1 secretion signal
AU2354588A (en) * 1987-10-09 1989-04-20 Collaborative Research Inc. Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
DE69033911D1 (de) * 1989-10-24 2002-03-14 Chiron Corp System zur freisetzung von infektiösen proteinen
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
AU4714799A (en) * 1998-06-26 2000-01-17 Croptech Development Corporation Production of urokinase in plant-based expression systems
AU2001269803A1 (en) * 2000-06-20 2002-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
JP5219819B2 (ja) 2005-10-21 2013-06-26 カタリスト・バイオサイエンシーズ・インコーポレイテッド 補体活性化を阻害する修飾プロテアーゼ
DK2046951T5 (da) 2006-07-05 2012-01-23 Catalyst Biosciences Inc Proteasesreeningsmetoder og proteaser identificeret dermed

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1382A (en) * 1979-11-13 1987-12-18 Syed Shaukat Husain Isolation of plasminogen activators useful as therapeutic and diagnostic agents
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
EP0143081B1 (de) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthese von Zellgewebsaktivator(TPA) durch Hefe

Also Published As

Publication number Publication date
AU1352483A (en) 1983-10-20
JPS5951300A (ja) 1984-03-24
EP0620279A1 (de) 1994-10-19
JPH0824579B2 (ja) 1996-03-13
ES8500325A1 (es) 1984-11-01
JPH0655145B2 (ja) 1994-07-27
ES8506087A1 (es) 1985-07-01
PH25312A (en) 1991-04-30
JPH07186A (ja) 1995-01-06
ATE232237T1 (de) 2003-02-15
EP0092182A3 (en) 1984-07-18
MY102472A (en) 1992-06-30
ES8602121A1 (es) 1985-12-01
HK38297A (en) 1997-04-04
CA1341301C (en) 2001-10-09
DE3382837D1 (de) 2003-03-13
PH22461A (en) 1988-09-12
IL68366A0 (en) 1983-07-31
DK163683A (da) 1983-11-28
IE830850L (en) 1983-10-15
FI831228L (fi) 1983-10-16
JPH0530970A (ja) 1993-02-09
PT76546A (en) 1983-05-01
IL83236A0 (en) 1987-12-31
JP2584192B2 (ja) 1997-02-19
BR8301918A (pt) 1983-12-20
DE3382760T2 (de) 1995-03-02
EP0092182A2 (de) 1983-10-26
DK163683D0 (da) 1983-04-14
DK173910B1 (da) 2002-02-11
ES521418A0 (es) 1984-11-01
IL68366A (en) 1990-08-31
FI831228A0 (fi) 1983-04-12
FI88932C (fi) 1993-07-26
NZ203869A (en) 1987-04-30
GR78180B (de) 1984-09-26
PT76546B (en) 1986-03-20
DE3382837T2 (de) 2004-01-15
DE3382760D1 (de) 1994-11-17
EP0620279B1 (de) 2003-02-05
ES533925A0 (es) 1985-12-01
EP0092182B1 (de) 1994-10-12
FI88932B (fi) 1993-04-15
IE950235L (en) 1983-10-15
YU86883A (en) 1988-10-31
AU573523B2 (en) 1988-06-16
PH25120A (en) 1991-02-19
ES533924A0 (es) 1985-07-01
NO831317L (no) 1983-10-17
ATE112802T1 (de) 1994-10-15
YU45128B (en) 1992-03-10
IE64536B1 (en) 1995-08-09

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