NO831317L - Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner. - Google Patents

Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner.

Info

Publication number
NO831317L
NO831317L NO831317A NO831317A NO831317L NO 831317 L NO831317 L NO 831317L NO 831317 A NO831317 A NO 831317A NO 831317 A NO831317 A NO 831317A NO 831317 L NO831317 L NO 831317L
Authority
NO
Norway
Prior art keywords
procedure
preparation
functional human
urokinase
proteins
Prior art date
Application number
NO831317A
Other languages
English (en)
Norwegian (no)
Inventor
Herbert Louis Heyneker
William Evans Holmes
Gordon Alan Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO831317L publication Critical patent/NO831317L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO831317A 1982-04-15 1983-04-14 Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner. NO831317L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (1)

Publication Number Publication Date
NO831317L true NO831317L (no) 1983-10-17

Family

ID=27004326

Family Applications (1)

Application Number Title Priority Date Filing Date
NO831317A NO831317L (no) 1982-04-15 1983-04-14 Fremgangsmaate for fremstilling av funksjonelle menneske-urokinase proteiner.

Country Status (20)

Country Link
EP (2) EP0092182B1 (de)
JP (3) JPH0655145B2 (de)
AT (2) ATE112802T1 (de)
AU (1) AU573523B2 (de)
BR (1) BR8301918A (de)
CA (1) CA1341301C (de)
DE (2) DE3382760T2 (de)
DK (1) DK173910B1 (de)
ES (3) ES521418A0 (de)
FI (1) FI88932C (de)
GR (1) GR78180B (de)
HK (1) HK38297A (de)
IE (1) IE64536B1 (de)
IL (2) IL68366A (de)
MY (1) MY102472A (de)
NO (1) NO831317L (de)
NZ (1) NZ203869A (de)
PH (4) PH24783A (de)
PT (1) PT76546B (de)
YU (1) YU45128B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NZ208612A (en) * 1983-06-24 1991-09-25 Genentech Inc Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
EP0139447B1 (de) * 1983-09-13 1992-12-30 The Green Cross Corporation Verfahren zur Herstellung von Urokinase Zymogen
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
EP0154272B1 (de) * 1984-02-27 1992-01-08 Green Cross Corporation Herstellung menschlicher Urokinase
WO1986004351A1 (en) * 1985-01-25 1986-07-31 Sagami Chemical Research Center Stabilized human prourokinase
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
WO1988005822A1 (en) * 1987-01-30 1988-08-11 American Home Products Corporation Des-epidermal growth factor plasminogen activators
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
DE3886517T2 (de) * 1987-08-19 1994-04-21 Sagami Chem Res Menschlicher Prourokinase ähnliches Polypeptid.
EP0310137B1 (de) * 1987-10-02 1994-01-26 Zymogenetics, Inc. BAR1-Sekretions-Signal-Sequenz
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
DE69033710T2 (de) * 1989-10-24 2001-06-13 Chiron Corp Sekretion vom mit Gamma-Interferon Signalpeptid gebundenen humänen Protein
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
JP2003525578A (ja) * 1998-06-26 2003-09-02 クロプテック・デヴェロップメント・コーポレイション 植物ベースの発現システムにおけるウロキナーゼの製造
US6833357B2 (en) 2000-06-20 2004-12-21 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
US20070093443A1 (en) * 2005-10-21 2007-04-26 Madison Edwin L Modified proteases that inhibit complement activation
WO2008045148A2 (en) 2006-07-05 2008-04-17 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1382A (en) * 1979-11-13 1987-12-18 Syed Shaukat Husain Isolation of plasminogen activators useful as therapeutic and diagnostic agents
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
FI86746C (fi) * 1983-11-21 1992-10-12 Ciba Geigy Ag Foerfarande foer framstaellning av maensklig vaevnads-plasminogenaktivator (tpa) med hjaelp av saccharomyces cerevisiae -jaest och i foerfarandet anvaenda hybridvektorer

Also Published As

Publication number Publication date
PH25312A (en) 1991-04-30
PT76546B (en) 1986-03-20
DK163683A (da) 1983-11-28
PH24783A (en) 1990-10-30
YU86883A (en) 1988-10-31
IL68366A (en) 1990-08-31
ATE112802T1 (de) 1994-10-15
DK173910B1 (da) 2002-02-11
YU45128B (en) 1992-03-10
IL68366A0 (en) 1983-07-31
JPH0824579B2 (ja) 1996-03-13
EP0620279A1 (de) 1994-10-19
ES8500325A1 (es) 1984-11-01
JP2584192B2 (ja) 1997-02-19
AU573523B2 (en) 1988-06-16
ES521418A0 (es) 1984-11-01
DE3382837D1 (de) 2003-03-13
FI831228A0 (fi) 1983-04-12
PH25120A (en) 1991-02-19
JPH0530970A (ja) 1993-02-09
DE3382760D1 (de) 1994-11-17
FI88932C (fi) 1993-07-26
JPH07186A (ja) 1995-01-06
JPS5951300A (ja) 1984-03-24
ES533924A0 (es) 1985-07-01
NZ203869A (en) 1987-04-30
EP0092182B1 (de) 1994-10-12
CA1341301C (en) 2001-10-09
AU1352483A (en) 1983-10-20
EP0092182A3 (en) 1984-07-18
FI831228L (fi) 1983-10-16
IE64536B1 (en) 1995-08-09
ATE232237T1 (de) 2003-02-15
HK38297A (en) 1997-04-04
DK163683D0 (da) 1983-04-14
IE950235L (en) 1983-10-15
PT76546A (en) 1983-05-01
ES8506087A1 (es) 1985-07-01
IE830850L (en) 1983-10-15
PH22461A (en) 1988-09-12
ES8602121A1 (es) 1985-12-01
DE3382760T2 (de) 1995-03-02
MY102472A (en) 1992-06-30
JPH0655145B2 (ja) 1994-07-27
FI88932B (fi) 1993-04-15
DE3382837T2 (de) 2004-01-15
BR8301918A (pt) 1983-12-20
ES533925A0 (es) 1985-12-01
IL83236A0 (en) 1987-12-31
GR78180B (de) 1984-09-26
EP0620279B1 (de) 2003-02-05
EP0092182A2 (de) 1983-10-26

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