ES8306755A1 - "procedimiento para la preparacion de nuevos derivados de azepina". - Google Patents

"procedimiento para la preparacion de nuevos derivados de azepina".

Info

Publication number
ES8306755A1
ES8306755A1 ES515730A ES515730A ES8306755A1 ES 8306755 A1 ES8306755 A1 ES 8306755A1 ES 515730 A ES515730 A ES 515730A ES 515730 A ES515730 A ES 515730A ES 8306755 A1 ES8306755 A1 ES 8306755A1
Authority
ES
Spain
Prior art keywords
hydrogen
mono
unsubstituted
alkoxycarbonyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515730A
Other languages
English (en)
Other versions
ES515730A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES515730A0 publication Critical patent/ES515730A0/es
Publication of ES8306755A1 publication Critical patent/ES8306755A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE AZEPINA Y DE SUS SALES CON ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE M Y N VALEN 1-3, SIENDO M+N=4; Y X, R Q, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA R -Z, EN LAS QUE R , R , R , X, M Y N TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), Y Z PUEDE SER VARIOS RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A TEMPERATURAS ENTRE 0 C Y 250 C, EN PRESENCIA DE UNA BASE, SI Z ES UN GRUPO SALIENTE NUCLEOFILO, Y EN PRESENCIA DE UN CATALIZADOR DE HIDROGENACION, SI Z ES UN GRUPO HIDROXI. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANTITROMBOTICO Y SOBRE EL METABOLISMO INTERMEDIARIO.
ES515730A 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina". Expired ES8306755A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813105858 DE3105858A1 (de) 1981-02-18 1981-02-18 "neue thieno-azepine, ihre herstellung und ihre verwendung als arzneimittel"

Publications (2)

Publication Number Publication Date
ES515730A0 ES515730A0 (es) 1983-06-01
ES8306755A1 true ES8306755A1 (es) 1983-06-01

Family

ID=6125118

Family Applications (4)

Application Number Title Priority Date Filing Date
ES509682A Granted ES509682A0 (es) 1981-02-18 1982-02-17 "procedimiento para la preparacion de nuevos derivados de azepina".
ES515729A Expired ES8306754A1 (es) 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina".
ES515728A Expired ES8306753A1 (es) 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina".
ES515730A Expired ES8306755A1 (es) 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina".

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES509682A Granted ES509682A0 (es) 1981-02-18 1982-02-17 "procedimiento para la preparacion de nuevos derivados de azepina".
ES515729A Expired ES8306754A1 (es) 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina".
ES515728A Expired ES8306753A1 (es) 1981-02-18 1982-09-15 "procedimiento para la preparacion de nuevos derivados de azepina".

Country Status (26)

Country Link
US (1) US4414225A (es)
EP (1) EP0058341B1 (es)
JP (1) JPS57150687A (es)
AR (1) AR231983A1 (es)
AT (1) ATE13298T1 (es)
AU (1) AU547951B2 (es)
CA (1) CA1171084A (es)
CS (1) CS227039B2 (es)
DD (1) DD202577A5 (es)
DE (2) DE3105858A1 (es)
DK (1) DK150157C (es)
ES (4) ES509682A0 (es)
FI (1) FI820509L (es)
GB (1) GB2093030B (es)
GR (1) GR76793B (es)
HU (1) HU190984B (es)
IE (1) IE52540B1 (es)
IL (1) IL65051A (es)
NO (1) NO157503C (es)
NZ (1) NZ199759A (es)
PH (1) PH17724A (es)
PL (1) PL137354B1 (es)
PT (1) PT74447B (es)
SU (1) SU1091858A3 (es)
YU (1) YU34982A (es)
ZA (1) ZA821020B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3230696A1 (de) * 1982-08-18 1984-02-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8800891D0 (en) * 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
GB8909132D0 (en) * 1989-04-21 1989-06-07 Lilly Industries Ltd Pharmaceutical compounds
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
GB9025890D0 (en) * 1990-11-28 1991-01-09 Lilly Industries Ltd Pharmaceutical compounds
CA2104371A1 (en) * 1991-12-26 1993-06-27 Tohru Nakao Condensed thiophene compound and pharmaceutical use thereof
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5696112A (en) * 1995-01-17 1997-12-09 American Cyanamid Company Fused heterocyclic azepines as vasopressin antagonists
FR2733750B1 (fr) * 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
US5939417A (en) * 1998-10-19 1999-08-17 Cell Pathways Inc 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
BRPI0512742A (pt) * 2004-06-30 2008-04-15 Athersys Inc composto, composição farmacêutica, e, método de tratamento de uma doença, distúrbio e/ou condição em um paciente em que modulação de uma função 5-ht2c é desejada
EP1796663B1 (en) * 2004-09-03 2011-05-04 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
BRPI0707183A2 (pt) * 2006-01-19 2011-04-26 Athersys Inc composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente
KR20150108840A (ko) 2012-12-21 2015-09-30 에이비티 홀딩 컴퍼니 세로토닌 5-ht2c 수용체 리간드로서 벤즈아제핀 및 그의 용도
WO2014159067A1 (en) 2013-03-13 2014-10-02 Abt Holding Company Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849441A (en) * 1971-10-01 1974-11-19 American Cyanamid Co Substituted heterocyclic derivatives of azepine
US3758501A (en) * 1971-10-01 1973-09-11 M Weiss Substituted heterocyclic derivatives of azepine
US3846446A (en) * 1971-10-01 1974-11-05 American Cyanamid Co Substituted heterocyclic derivatives of azepine

Also Published As

Publication number Publication date
ES515729A0 (es) 1983-06-01
PT74447B (de) 1984-10-09
NO820493L (no) 1982-08-19
ES515728A0 (es) 1983-06-01
ES515730A0 (es) 1983-06-01
GB2093030B (en) 1985-01-16
GR76793B (es) 1984-09-04
ZA821020B (en) 1983-10-26
CA1171084A (en) 1984-07-17
YU34982A (en) 1985-04-30
ES8304987A1 (es) 1983-03-16
EP0058341A1 (de) 1982-08-25
JPS57150687A (en) 1982-09-17
IL65051A0 (en) 1982-04-30
HUT34754A (en) 1985-04-28
NZ199759A (en) 1985-09-13
PL137354B1 (en) 1986-05-31
ES509682A0 (es) 1983-03-16
HU190984B (en) 1986-12-28
NO157503C (no) 1988-03-30
NO157503B (no) 1987-12-21
IL65051A (en) 1986-11-30
AU547951B2 (en) 1985-11-14
EP0058341B1 (de) 1985-05-15
ES8306753A1 (es) 1983-06-01
AR231983A1 (es) 1985-04-30
PT74447A (de) 1982-03-01
DD202577A5 (de) 1983-09-21
CS227039B2 (en) 1984-04-16
ATE13298T1 (de) 1985-06-15
DE3263462D1 (en) 1985-06-20
GB2093030A (en) 1982-08-25
IE820338L (en) 1982-08-18
IE52540B1 (en) 1987-12-09
AU8055282A (en) 1982-08-26
US4414225A (en) 1983-11-08
DK150157C (da) 1987-06-29
PH17724A (en) 1984-11-21
SU1091858A3 (ru) 1984-05-07
FI820509L (fi) 1982-08-19
DK150157B (da) 1986-12-22
PL235121A1 (es) 1982-10-25
ES8306754A1 (es) 1983-06-01
DE3105858A1 (de) 1982-09-02
DK69382A (da) 1982-08-19

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