ZA821020B - Azepine derivatives, process for their preparation and pharmaceutical compositions thereof - Google Patents
Azepine derivatives, process for their preparation and pharmaceutical compositions thereofInfo
- Publication number
- ZA821020B ZA821020B ZA821020A ZA821020A ZA821020B ZA 821020 B ZA821020 B ZA 821020B ZA 821020 A ZA821020 A ZA 821020A ZA 821020 A ZA821020 A ZA 821020A ZA 821020 B ZA821020 B ZA 821020B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparation
- pharmaceutical compositions
- azepine derivatives
- azepine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813105858 DE3105858A1 (de) | 1981-02-18 | 1981-02-18 | "neue thieno-azepine, ihre herstellung und ihre verwendung als arzneimittel" |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA821020B true ZA821020B (en) | 1983-10-26 |
Family
ID=6125118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA821020A ZA821020B (en) | 1981-02-18 | 1981-02-17 | Azepine derivatives, process for their preparation and pharmaceutical compositions thereof |
Country Status (26)
Country | Link |
---|---|
US (1) | US4414225A (xx) |
EP (1) | EP0058341B1 (xx) |
JP (1) | JPS57150687A (xx) |
AR (1) | AR231983A1 (xx) |
AT (1) | ATE13298T1 (xx) |
AU (1) | AU547951B2 (xx) |
CA (1) | CA1171084A (xx) |
CS (1) | CS227039B2 (xx) |
DD (1) | DD202577A5 (xx) |
DE (2) | DE3105858A1 (xx) |
DK (1) | DK150157C (xx) |
ES (4) | ES509682A0 (xx) |
FI (1) | FI820509L (xx) |
GB (1) | GB2093030B (xx) |
GR (1) | GR76793B (xx) |
HU (1) | HU190984B (xx) |
IE (1) | IE52540B1 (xx) |
IL (1) | IL65051A (xx) |
NO (1) | NO157503C (xx) |
NZ (1) | NZ199759A (xx) |
PH (1) | PH17724A (xx) |
PL (1) | PL137354B1 (xx) |
PT (1) | PT74447B (xx) |
SU (1) | SU1091858A3 (xx) |
YU (1) | YU34982A (xx) |
ZA (1) | ZA821020B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
DE3230696A1 (de) * | 1982-08-18 | 1984-02-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB8800891D0 (en) * | 1988-01-15 | 1988-02-17 | Lilly Industries Ltd | Pharmaceutical compounds |
GB8909132D0 (en) * | 1989-04-21 | 1989-06-07 | Lilly Industries Ltd | Pharmaceutical compounds |
FR2652579B1 (fr) * | 1989-10-02 | 1992-01-24 | Sanofi Sa | Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique. |
GB9025890D0 (en) * | 1990-11-28 | 1991-01-09 | Lilly Industries Ltd | Pharmaceutical compounds |
CA2104371A1 (en) * | 1991-12-26 | 1993-06-27 | Tohru Nakao | Condensed thiophene compound and pharmaceutical use thereof |
US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5696112A (en) * | 1995-01-17 | 1997-12-09 | American Cyanamid Company | Fused heterocyclic azepines as vasopressin antagonists |
FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
US5939417A (en) * | 1998-10-19 | 1999-08-17 | Cell Pathways Inc | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia |
BRPI0512742A (pt) * | 2004-06-30 | 2008-04-15 | Athersys Inc | composto, composição farmacêutica, e, método de tratamento de uma doença, distúrbio e/ou condição em um paciente em que modulação de uma função 5-ht2c é desejada |
EP1796663B1 (en) * | 2004-09-03 | 2011-05-04 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
BRPI0707183A2 (pt) * | 2006-01-19 | 2011-04-26 | Athersys Inc | composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente |
KR20150108840A (ko) | 2012-12-21 | 2015-09-30 | 에이비티 홀딩 컴퍼니 | 세로토닌 5-ht2c 수용체 리간드로서 벤즈아제핀 및 그의 용도 |
WO2014159067A1 (en) | 2013-03-13 | 2014-10-02 | Abt Holding Company | Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3849441A (en) * | 1971-10-01 | 1974-11-19 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
US3758501A (en) * | 1971-10-01 | 1973-09-11 | M Weiss | Substituted heterocyclic derivatives of azepine |
US3846446A (en) * | 1971-10-01 | 1974-11-05 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
-
1981
- 1981-02-17 ZA ZA821020A patent/ZA821020B/xx unknown
- 1981-02-18 DE DE19813105858 patent/DE3105858A1/de not_active Withdrawn
-
1982
- 1982-02-03 EP EP82100745A patent/EP0058341B1/de not_active Expired
- 1982-02-03 AT AT82100745T patent/ATE13298T1/de not_active IP Right Cessation
- 1982-02-03 DE DE8282100745T patent/DE3263462D1/de not_active Expired
- 1982-02-11 SU SU823388045A patent/SU1091858A3/ru active
- 1982-02-12 US US06/348,496 patent/US4414225A/en not_active Expired - Fee Related
- 1982-02-15 GR GR67317A patent/GR76793B/el unknown
- 1982-02-16 CA CA000396329A patent/CA1171084A/en not_active Expired
- 1982-02-16 PH PH26951A patent/PH17724A/en unknown
- 1982-02-16 FI FI820509A patent/FI820509L/fi not_active Application Discontinuation
- 1982-02-16 DD DD82237445A patent/DD202577A5/de unknown
- 1982-02-17 PL PL1982235121A patent/PL137354B1/pl unknown
- 1982-02-17 NZ NZ199759A patent/NZ199759A/xx unknown
- 1982-02-17 YU YU00349/82A patent/YU34982A/xx unknown
- 1982-02-17 NO NO820493A patent/NO157503C/no unknown
- 1982-02-17 IE IE338/82A patent/IE52540B1/en unknown
- 1982-02-17 DK DK069382A patent/DK150157C/da not_active IP Right Cessation
- 1982-02-17 PT PT74447A patent/PT74447B/pt unknown
- 1982-02-17 GB GB8204585A patent/GB2093030B/en not_active Expired
- 1982-02-17 JP JP57024249A patent/JPS57150687A/ja active Pending
- 1982-02-17 ES ES509682A patent/ES509682A0/es active Granted
- 1982-02-17 AU AU80552/82A patent/AU547951B2/en not_active Ceased
- 1982-02-18 AR AR288469A patent/AR231983A1/es active
- 1982-02-18 IL IL65051A patent/IL65051A/xx unknown
- 1982-02-18 CS CS821126A patent/CS227039B2/cs unknown
- 1982-02-18 HU HU82499A patent/HU190984B/hu unknown
- 1982-09-15 ES ES515729A patent/ES8306754A1/es not_active Expired
- 1982-09-15 ES ES515728A patent/ES8306753A1/es not_active Expired
- 1982-09-15 ES ES515730A patent/ES8306755A1/es not_active Expired
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