CS227039B2 - Method of preparing new azepine derivatives - Google Patents
Method of preparing new azepine derivatives Download PDFInfo
- Publication number
- CS227039B2 CS227039B2 CS821126A CS112682A CS227039B2 CS 227039 B2 CS227039 B2 CS 227039B2 CS 821126 A CS821126 A CS 821126A CS 112682 A CS112682 A CS 112682A CS 227039 B2 CS227039 B2 CS 227039B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- tetrahydro
- azepine
- carbon atoms
- mol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813105858 DE3105858A1 (de) | 1981-02-18 | 1981-02-18 | "neue thieno-azepine, ihre herstellung und ihre verwendung als arzneimittel" |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS227039B2 true CS227039B2 (en) | 1984-04-16 |
Family
ID=6125118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS821126A CS227039B2 (en) | 1981-02-18 | 1982-02-18 | Method of preparing new azepine derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4414225A (es) |
| EP (1) | EP0058341B1 (es) |
| JP (1) | JPS57150687A (es) |
| AR (1) | AR231983A1 (es) |
| AT (1) | ATE13298T1 (es) |
| AU (1) | AU547951B2 (es) |
| CA (1) | CA1171084A (es) |
| CS (1) | CS227039B2 (es) |
| DD (1) | DD202577A5 (es) |
| DE (2) | DE3105858A1 (es) |
| DK (1) | DK150157C (es) |
| ES (4) | ES509682A0 (es) |
| FI (1) | FI820509L (es) |
| GB (1) | GB2093030B (es) |
| GR (1) | GR76793B (es) |
| HU (1) | HU190984B (es) |
| IE (1) | IE52540B1 (es) |
| IL (1) | IL65051A (es) |
| NO (1) | NO157503C (es) |
| NZ (1) | NZ199759A (es) |
| PH (1) | PH17724A (es) |
| PL (1) | PL137354B1 (es) |
| PT (1) | PT74447B (es) |
| SU (1) | SU1091858A3 (es) |
| YU (1) | YU34982A (es) |
| ZA (1) | ZA821020B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| DE3230696A1 (de) * | 1982-08-18 | 1984-02-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8800891D0 (en) * | 1988-01-15 | 1988-02-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB8909132D0 (en) * | 1989-04-21 | 1989-06-07 | Lilly Industries Ltd | Pharmaceutical compounds |
| FR2652579B1 (fr) * | 1989-10-02 | 1992-01-24 | Sanofi Sa | Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique. |
| GB9025890D0 (en) * | 1990-11-28 | 1991-01-09 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5532240A (en) * | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| KR930703327A (ko) * | 1991-12-26 | 1993-11-29 | 고야 다다시 | 축합형 티오펜 화합물 및 그의 의약용도 |
| US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5696112A (en) * | 1995-01-17 | 1997-12-09 | American Cyanamid Company | Fused heterocyclic azepines as vasopressin antagonists |
| FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| US5939417A (en) * | 1998-10-19 | 1999-08-17 | Cell Pathways Inc | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia |
| RU2485125C2 (ru) * | 2004-06-30 | 2013-06-20 | Эсерсис, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ АЗЕПИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, РАССТРОЙСТВ И/ИЛИ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ, ПРИ КОТОРЫХ ЖЕЛАТЕЛЬНО МОДУЛИРОВАНИЕ ФУНКЦИИ 5HT2c-РЕЦЕПТОРОВ |
| WO2006028961A2 (en) * | 2004-09-03 | 2006-03-16 | Athersys, Inc. | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators |
| MX2008009178A (es) * | 2006-01-19 | 2008-12-05 | Athersys Inc | Tiofenil y pirrolil acepinas como ligandos del receptor de serotonina 5-ht2c y sus usos. |
| WO2014100815A2 (en) | 2012-12-21 | 2014-06-26 | Abt Holding Company | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
| US9309262B2 (en) | 2013-03-13 | 2016-04-12 | Abt Holding Company | Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3758501A (en) * | 1971-10-01 | 1973-09-11 | M Weiss | Substituted heterocyclic derivatives of azepine |
| US3849441A (en) * | 1971-10-01 | 1974-11-19 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
| US3846446A (en) * | 1971-10-01 | 1974-11-05 | American Cyanamid Co | Substituted heterocyclic derivatives of azepine |
-
1981
- 1981-02-17 ZA ZA821020A patent/ZA821020B/xx unknown
- 1981-02-18 DE DE19813105858 patent/DE3105858A1/de not_active Withdrawn
-
1982
- 1982-02-03 DE DE8282100745T patent/DE3263462D1/de not_active Expired
- 1982-02-03 AT AT82100745T patent/ATE13298T1/de not_active IP Right Cessation
- 1982-02-03 EP EP82100745A patent/EP0058341B1/de not_active Expired
- 1982-02-11 SU SU823388045A patent/SU1091858A3/ru active
- 1982-02-12 US US06/348,496 patent/US4414225A/en not_active Expired - Fee Related
- 1982-02-15 GR GR67317A patent/GR76793B/el unknown
- 1982-02-16 DD DD82237445A patent/DD202577A5/de unknown
- 1982-02-16 PH PH26951A patent/PH17724A/en unknown
- 1982-02-16 FI FI820509A patent/FI820509L/fi not_active Application Discontinuation
- 1982-02-16 CA CA000396329A patent/CA1171084A/en not_active Expired
- 1982-02-17 NO NO820493A patent/NO157503C/no unknown
- 1982-02-17 JP JP57024249A patent/JPS57150687A/ja active Pending
- 1982-02-17 ES ES509682A patent/ES509682A0/es active Granted
- 1982-02-17 YU YU00349/82A patent/YU34982A/xx unknown
- 1982-02-17 PL PL1982235121A patent/PL137354B1/pl unknown
- 1982-02-17 GB GB8204585A patent/GB2093030B/en not_active Expired
- 1982-02-17 IE IE338/82A patent/IE52540B1/en unknown
- 1982-02-17 PT PT74447A patent/PT74447B/pt unknown
- 1982-02-17 NZ NZ199759A patent/NZ199759A/xx unknown
- 1982-02-17 AU AU80552/82A patent/AU547951B2/en not_active Ceased
- 1982-02-17 DK DK069382A patent/DK150157C/da not_active IP Right Cessation
- 1982-02-18 IL IL65051A patent/IL65051A/xx unknown
- 1982-02-18 AR AR288469A patent/AR231983A1/es active
- 1982-02-18 CS CS821126A patent/CS227039B2/cs unknown
- 1982-02-18 HU HU82499A patent/HU190984B/hu unknown
- 1982-09-15 ES ES515729A patent/ES8306754A1/es not_active Expired
- 1982-09-15 ES ES515730A patent/ES8306755A1/es not_active Expired
- 1982-09-15 ES ES515728A patent/ES8306753A1/es not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CS227039B2 (en) | Method of preparing new azepine derivatives | |
| JP2506105B2 (ja) | 抗高血圧活性を有する４，５，６，７−テトラヒドロ−１ｈ−イミダゾ〔４，５−ｃ〕ピリジン−６−カルボン酸類似体 | |
| EP0223420B1 (en) | Condensed imidazopyridine derivatives | |
| US4062848A (en) | Tetracyclic compounds | |
| EP0587473B1 (fr) | Dérivés condensés de la pyridine comme inhibiteurs de l'effet des radicaux libres | |
| JP2623800B2 (ja) | チエノジアゼピン化合物 | |
| US4556653A (en) | Pyrido[1,5]benzodiazepinone derivatives and pharmacological activities thereof | |
| EP0091241A2 (en) | Condensed pyrrolinone derivatives, and their production | |
| HU218950B (hu) | Kondenzált imidazo-piridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
| CS254992B2 (en) | Method of thieno-triazolo-1,4-diazepino-2-carboxyl acids' new amides production | |
| US4193998A (en) | 1,2,3,4,6,7-Hexahydro-11BαH-benzo[a]quinolizine-derivatives | |
| HU197011B (en) | Process for producing new imidazo- and triazolo-1,4-benzodiazepines and pharmaceuticals comprising the same | |
| SU1282818A3 (ru) | Способ получени ортоконденсированных производных пиррола | |
| CS207619B2 (en) | Method of making the new derivatives of 5,11-dihydro-6h-pyrido 2,3-b 1,4 benzodiazepin-6-on | |
| US5602131A (en) | EburnanE analogues | |
| HU198937B (en) | Process for producing indolopyrazino benzodiazepine derivatives and pharmaceutical compositions comprising same | |
| US4511569A (en) | Tricyclic lactams and derivatives useful in increasing cardiac contractility | |
| US3928368A (en) | Alcohol derivatives of pyrazolo{8 3,4-b{9 pyridines | |
| EP0231138B1 (fr) | Dérivés d'acylaminométhyl-1imidazo [1,2-a] quinoléines, leur préparation et leur application en thérapeutique | |
| US4559402A (en) | Pyrazolopyridines and tetrahydro pyrazolopyridines | |
| US4038281A (en) | Certain 2,7-dihydro-4H-pyrazolo[3,4-b]pyridine-5-ketones | |
| PT97570A (pt) | Processo para a preparacao de derivados de benzotienopiridina | |
| US4033970A (en) | Various 1,5,10,11-tetrahydrobenzo [4,5]-cyclohepta [1,2-b]pyrazolo[4,3-e]pyridine derivatives | |
| US4500708A (en) | Benzothiazine derivatives | |
| SU422149A3 (ru) | Способ получения производных азепина или их солеи |