ES487769A1 - Un procedimiento para la preparacion de un nuevo derivado de acido cicloalquilidenmetilfenilacetico - Google Patents
Un procedimiento para la preparacion de un nuevo derivado de acido cicloalquilidenmetilfenilaceticoInfo
- Publication number
- ES487769A1 ES487769A1 ES487769A ES487769A ES487769A1 ES 487769 A1 ES487769 A1 ES 487769A1 ES 487769 A ES487769 A ES 487769A ES 487769 A ES487769 A ES 487769A ES 487769 A1 ES487769 A1 ES 487769A1
- Authority
- ES
- Spain
- Prior art keywords
- acid derivatives
- preparation
- cycloalkanone
- cycloalkylidenemethylphenylacetic
- cycloalkylidenemethylphenylacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un nuevo derivado de ácido cicloalquilidenmetilfenilacético, útil como agente anti-inflamatorio, analgésico o antipirético de fórmula **fórmula** (dónde R1 y r2 son iguales o diferentes y cada uno de ellos representa un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono y n es 1, 2 o 3) cuyo procedimiento se caracteriza por: a) someter a reacción de condensación un derivado de un éster del ácido p-formilfenilacético de fórmula **fórmula ** (Dónde R1 es el definido anteriormente y R3 es un grupo alquilo de 1 a 6 átomos de carbono) con un derivado de enamina de fórmula **fórmula ** (dónde R4 y r5 son iguales o diferentes y cada uno de ellos representa un grupo alquilo de 1 a 6 átomos de carbono o unidos forman, junto con el átomo de nitrógeno al que están enlazados, un grupo amino cíclico opcionalmente con un átomo de oxígeno en el anillo y n es el definido anteriormente) e hidrolizar el producto de condensación; b) cuando R2 es alquilo en el compuesto (I) de la etapa (a) , opcionalmente hidrolizar el compuesto (I) para dar un compuesto (I) donde R2 es hidrógeno y/o c) cuando R2 es hidrógeno en el compuesto (I) de la etapa (a) , o cuando se realiza la etapa (b), opcionalmente salificar el compuesto (I)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9812177A JPS5432460A (en) | 1977-08-16 | 1977-08-16 | Cycloalkylidenemethylphenylacetic acid derivative and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES487769A1 true ES487769A1 (es) | 1980-10-01 |
Family
ID=14211452
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472588A Expired ES472588A1 (es) | 1977-08-16 | 1978-08-16 | Un procedimiento para la preparacion de un nuevo derivado deacido cicloalquilidenmetilfenilacetico |
ES487769A Expired ES487769A1 (es) | 1977-08-16 | 1980-01-16 | Un procedimiento para la preparacion de un nuevo derivado de acido cicloalquilidenmetilfenilacetico |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472588A Expired ES472588A1 (es) | 1977-08-16 | 1978-08-16 | Un procedimiento para la preparacion de un nuevo derivado deacido cicloalquilidenmetilfenilacetico |
Country Status (13)
Country | Link |
---|---|
US (2) | US4254274A (es) |
JP (1) | JPS5432460A (es) |
BE (1) | BE869721A (es) |
CA (1) | CA1113114A (es) |
CH (1) | CH636839A5 (es) |
DE (1) | DE2835701C2 (es) |
DK (1) | DK151251C (es) |
ES (2) | ES472588A1 (es) |
FR (1) | FR2400500A1 (es) |
GB (1) | GB2002762B (es) |
IT (1) | IT1118095B (es) |
MX (1) | MX5149E (es) |
NL (1) | NL189561C (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS574919A (en) * | 1980-06-09 | 1982-01-11 | Sankyo Co Ltd | Anti-inflammatory for external use |
CH645539A5 (de) * | 1980-06-09 | 1984-10-15 | Sankyo Co | Antiinflammatorische mittel fuer die aeusserliche anwendung. |
JPS57103950A (en) * | 1980-12-19 | 1982-06-28 | Nok Corp | Belt with special profile and manufacture of the same |
JPS58105939A (ja) * | 1981-12-18 | 1983-06-24 | Sankyo Co Ltd | 置換フエニル酢酸誘導体及びその製法 |
JPS6038323A (ja) * | 1983-08-10 | 1985-02-27 | Sankyo Co Ltd | 眼科用消炎剤 |
JPS6122043A (ja) * | 1984-07-10 | 1986-01-30 | Sankyo Co Ltd | シクロアルキリデンメチルフエニル酢酸誘導体の製法 |
US5244920A (en) * | 1985-04-15 | 1993-09-14 | Schering Spa | Pharmaceutical compositions having therapeutical activity based on mercaptoethansulphonic arginine salt |
IT1185551B (it) * | 1985-04-15 | 1987-11-12 | Schering Spa | Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione |
JPH08116881A (ja) * | 1994-10-26 | 1996-05-14 | Yutaka Koizumi | 茶葉の微粉化方法、それにより得られる超微粉末茶ならびにそれを用いた茶飲料および飲食物 |
KR100501993B1 (ko) * | 1998-11-20 | 2005-10-26 | 주식회사 코오롱 | 페닐프로피온산 유도체 또는 그의 염의 제조방법 |
IT1308633B1 (it) | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
US6392053B2 (en) * | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
TW200827343A (en) | 2006-09-11 | 2008-07-01 | Fuji Yakuhin Co Ltd | Novel phenylacetic acid derivative |
KR100922519B1 (ko) | 2008-11-12 | 2009-10-20 | 대원제약주식회사 | 펠루비프로펜을 함유하는 용출률 및 안정성이 개선된 경구투여용 약제학적 제제 |
CN106316837B (zh) * | 2015-06-24 | 2020-04-24 | 浙江九洲药业股份有限公司 | 一种取代苯乙酸衍生物的制备方法 |
CN106699559B (zh) * | 2015-11-12 | 2021-04-06 | 浙江九洲药业股份有限公司 | 一种洛索洛芬钠的制备工艺 |
KR20200069617A (ko) | 2018-12-07 | 2020-06-17 | 엠에프씨 주식회사 | 플루비프로펜의 제조방법 |
KR20220039116A (ko) | 2020-09-21 | 2022-03-29 | 엠에프씨 주식회사 | 고순도 펠루비프로펜의 제조방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3729509A (en) * | 1970-04-20 | 1973-04-24 | Merck & Co Inc | (mono-and diacylvinyl)aryl alkanoic(and alkenoic)acids |
JPS5740132B2 (es) * | 1975-02-19 | 1982-08-25 |
-
1977
- 1977-08-16 JP JP9812177A patent/JPS5432460A/ja active Granted
-
1978
- 1978-08-01 US US05/929,937 patent/US4254274A/en not_active Expired - Lifetime
- 1978-08-07 GB GB7832509A patent/GB2002762B/en not_active Expired
- 1978-08-11 CA CA309,215A patent/CA1113114A/en not_active Expired
- 1978-08-11 BE BE78189875A patent/BE869721A/xx not_active IP Right Cessation
- 1978-08-15 CH CH866578A patent/CH636839A5/de not_active IP Right Cessation
- 1978-08-15 DK DK360278A patent/DK151251C/da not_active IP Right Cessation
- 1978-08-16 FR FR7823871A patent/FR2400500A1/fr active Granted
- 1978-08-16 ES ES472588A patent/ES472588A1/es not_active Expired
- 1978-08-16 MX MX787315U patent/MX5149E/es unknown
- 1978-08-16 DE DE2835701A patent/DE2835701C2/de not_active Expired
- 1978-08-16 NL NLAANVRAGE7808503,A patent/NL189561C/xx not_active IP Right Cessation
- 1978-08-16 IT IT68914/78A patent/IT1118095B/it active
-
1980
- 1980-01-16 ES ES487769A patent/ES487769A1/es not_active Expired
- 1980-10-14 US US06/197,229 patent/US4365076A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2400500B1 (es) | 1983-10-28 |
NL7808503A (nl) | 1979-02-20 |
JPS5432460A (en) | 1979-03-09 |
CA1113114A (en) | 1981-11-24 |
CH636839A5 (de) | 1983-06-30 |
JPS5757019B2 (es) | 1982-12-02 |
GB2002762A (en) | 1979-02-28 |
MX5149E (es) | 1983-04-04 |
DK360278A (da) | 1979-02-17 |
DK151251B (da) | 1987-11-16 |
DE2835701C2 (de) | 1986-12-11 |
ES472588A1 (es) | 1980-04-16 |
DE2835701A1 (de) | 1979-03-01 |
FR2400500A1 (fr) | 1979-03-16 |
DK151251C (da) | 1988-05-09 |
BE869721A (fr) | 1979-02-12 |
IT7868914A0 (it) | 1978-08-16 |
GB2002762B (en) | 1982-04-07 |
IT1118095B (it) | 1986-02-24 |
NL189561C (nl) | 1993-05-17 |
NL189561B (nl) | 1992-12-16 |
US4254274A (en) | 1981-03-03 |
US4365076A (en) | 1982-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20001002 |