JPS574919A - Anti-inflammatory for external use - Google Patents
Anti-inflammatory for external useInfo
- Publication number
- JPS574919A JPS574919A JP7732180A JP7732180A JPS574919A JP S574919 A JPS574919 A JP S574919A JP 7732180 A JP7732180 A JP 7732180A JP 7732180 A JP7732180 A JP 7732180A JP S574919 A JPS574919 A JP S574919A
- Authority
- JP
- Japan
- Prior art keywords
- inflammatory
- external use
- novel
- formula
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PURPOSE: An ati-inflammatory for external use that contains one of specific phenylacetic derivatives some of which are novel, thus showing high activity.
CONSTITUTION: The objective anti-inflammatory includes a phenylacetic derivative of the formula (R1 is H, lower alkyl; R2 is H, lower alkyl, aralkyl, pyridylmethyl; >A-B- is >CH-CH2-, >C=CH-; n is 1, 2) such as 2-[4-(2-oxocyclopentan-1- ylmethyl)phenyl]propionic acid. Some of the compounds of the formula are novel. They show remarkable anti-inflammatory activity when locally applied and high percutaneous absorption. Therefore, they are used in the form of cream, ointment or lotion for wounds, ambustions, eczemas and contact dermatitis.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7732180A JPS574919A (en) | 1980-06-09 | 1980-06-09 | Anti-inflammatory for external use |
CH364581A CH645539A5 (en) | 1980-06-09 | 1981-06-03 | Anti-inflammatory agents for external application. |
IT67784/81A IT1193734B (en) | 1980-06-09 | 1981-06-08 | ANTI-INFLAMMATORY AGENT FOR EXTERNAL USE IN MEN AND ANIMALS |
CA000379199A CA1169776A (en) | 1980-06-09 | 1981-06-08 | Anti inflammatory phenylacetic acid derivatives for external use |
NL8102775A NL192371C (en) | 1980-06-09 | 1981-06-09 | Anti-inflammatory agents for external use, as well as compounds suitable for use in such a composition. |
GB8117684A GB2078732B (en) | 1980-06-09 | 1981-06-09 | Anti-inflammatory phenylacetic acid derivatives for external use |
SE8103598A SE8103598L (en) | 1980-06-09 | 1981-06-09 | ANTI-INFLAMMATORY EXTERNAL USE |
FR8111293A FR2483918B1 (en) | 1980-06-09 | 1981-06-09 | ANTI-INFLAMMATORY COMPOSITION CONTAINING AS ACTIVE INGREDIENT DERIVATIVES OF PHENYL-ACETIC OR PHENYL-PROPIONIC ACID |
DE19813122791 DE3122791A1 (en) | 1980-06-09 | 1981-06-09 | "ANTI-INFLAMMATORY COMPOSITION FOR EXTERNAL USE AND NEW PHENYL ACETIC AND PHENYL PROPION ACID DERIVATIVES" |
BE0/205045A BE889149A (en) | 1980-06-09 | 1981-06-09 | ANTI-INFLAMMATORY COMPOSITION AND COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7732180A JPS574919A (en) | 1980-06-09 | 1980-06-09 | Anti-inflammatory for external use |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS574919A true JPS574919A (en) | 1982-01-11 |
Family
ID=13630664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7732180A Pending JPS574919A (en) | 1980-06-09 | 1980-06-09 | Anti-inflammatory for external use |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS574919A (en) |
BE (1) | BE889149A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993002999A1 (en) * | 1991-08-10 | 1993-02-18 | Hisamitsu Pharmaceutical Co., Inc. | Phenylalkanoic acid derivative, production thereof, and separation of optical isomers thereof |
WO1998008966A1 (en) | 1996-08-26 | 1998-03-05 | Sankyo Company, Limited | Loxoprofen-containing preparation for external use |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52145525A (en) * | 1976-05-13 | 1977-12-03 | Johnson & Johnson | Local antiiinflammation agent |
JPS5381616A (en) * | 1976-12-27 | 1978-07-19 | Kowa Co | Production of antiinflammatory and anodyne ointment |
JPS53135958A (en) * | 1977-04-05 | 1978-11-28 | Sankyo Co Ltd | Substituted phenylacetic acid derivatives and their preparation |
JPS5432460A (en) * | 1977-08-16 | 1979-03-09 | Sankyo Co Ltd | Cycloalkylidenemethylphenylacetic acid derivative and their preparation |
-
1980
- 1980-06-09 JP JP7732180A patent/JPS574919A/en active Pending
-
1981
- 1981-06-09 BE BE0/205045A patent/BE889149A/en not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52145525A (en) * | 1976-05-13 | 1977-12-03 | Johnson & Johnson | Local antiiinflammation agent |
JPS5381616A (en) * | 1976-12-27 | 1978-07-19 | Kowa Co | Production of antiinflammatory and anodyne ointment |
JPS53135958A (en) * | 1977-04-05 | 1978-11-28 | Sankyo Co Ltd | Substituted phenylacetic acid derivatives and their preparation |
JPS5432460A (en) * | 1977-08-16 | 1979-03-09 | Sankyo Co Ltd | Cycloalkylidenemethylphenylacetic acid derivative and their preparation |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993002999A1 (en) * | 1991-08-10 | 1993-02-18 | Hisamitsu Pharmaceutical Co., Inc. | Phenylalkanoic acid derivative, production thereof, and separation of optical isomers thereof |
WO1998008966A1 (en) | 1996-08-26 | 1998-03-05 | Sankyo Company, Limited | Loxoprofen-containing preparation for external use |
US6248350B1 (en) | 1996-08-26 | 2001-06-19 | Lead Chemical Co., Ltd. | External formulation containing loxoprofen |
Also Published As
Publication number | Publication date |
---|---|
BE889149A (en) | 1981-12-09 |
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