ES8503686A1 - Procedimiento de preparar derivados de penicilina. - Google Patents

Procedimiento de preparar derivados de penicilina.

Info

Publication number
ES8503686A1
ES8503686A1 ES523701A ES523701A ES8503686A1 ES 8503686 A1 ES8503686 A1 ES 8503686A1 ES 523701 A ES523701 A ES 523701A ES 523701 A ES523701 A ES 523701A ES 8503686 A1 ES8503686 A1 ES 8503686A1
Authority
ES
Spain
Prior art keywords
same
carboxyl group
preparation
penicillin derivatives
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523701A
Other languages
English (en)
Other versions
ES523701A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57107171A external-priority patent/JPS58225091A/ja
Priority claimed from JP57233967A external-priority patent/JPS59118790A/ja
Priority claimed from JP58021200A external-priority patent/JPS59148788A/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES8503686A1 publication Critical patent/ES8503686A1/es
Publication of ES523701A0 publication Critical patent/ES523701A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR DERIVADOS DE PENICILINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN DERIVADO DE ACETILENO DE FORMULA (III), Y REALIZAR UNA DESESTERIFICACION, UNA ESTERIFICACION SUBSIGUIENTE A LA DESESTERIFICACION, UNA REACCION DE INTERCAMBIO DE ESTERES, O UNA REACCION DE FORMACION DE SALES CUANDO SE REQUIERA, PARA OBTENER LOS DERIVADOS DE PENICILINA Y SUS SALES FARMACOLOGICAMENTE ACEPTABLES DE FORMULA (I). SIENDO: R1, H, UN GRUPO TRIALQUILSILILO, UN GRUPO CARBOXILO O UN GRUPO CARBOXILO ESTERIFICADO; R3, ES UN GRUPO PROTECTOR DEL CARBOXILO DE PENICILINA Y R4 ES UN GRUPO TRIALQUILSILILO, UN GRUPO CARBOXILO O UN GRUPO CARBOXILO ESTERIFICADO.SE UTILIZAN COMO FARMACOS POR SU ACCION INHIBIDORA DE LA BETA-LACTAMASA.
ES523701A 1982-06-21 1983-06-20 Procedimiento de preparar derivados de penicilina. Granted ES523701A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP57107171A JPS58225091A (ja) 1982-06-21 1982-06-21 ペニシリン誘導体及びその製造法
JP57233967A JPS59118790A (ja) 1982-12-24 1982-12-24 ペニシリン誘導体
JP58021200A JPS59148788A (ja) 1983-02-10 1983-02-10 ペニシリン誘導体

Publications (2)

Publication Number Publication Date
ES8503686A1 true ES8503686A1 (es) 1985-03-16
ES523701A0 ES523701A0 (es) 1985-03-16

Family

ID=27283331

Family Applications (2)

Application Number Title Priority Date Filing Date
ES523701A Granted ES523701A0 (es) 1982-06-21 1983-06-20 Procedimiento de preparar derivados de penicilina.
ES538020A Expired ES8600765A1 (es) 1982-06-21 1984-11-27 Procedimiento de preparar derivados de penicilina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES538020A Expired ES8600765A1 (es) 1982-06-21 1984-11-27 Procedimiento de preparar derivados de penicilina

Country Status (5)

Country Link
EP (1) EP0097446B1 (es)
AU (1) AU541028B2 (es)
DE (1) DE3362277D1 (es)
ES (2) ES523701A0 (es)
NL (1) NL930140I2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1239392A (en) * 1983-10-13 1988-07-19 Shigeru Yamabe Penicillin derivatives and process for preparing the same
JPS60214792A (ja) * 1984-04-06 1985-10-28 Taiho Yakuhin Kogyo Kk ペナム酸エステル誘導体
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
JP2603082B2 (ja) * 1987-09-07 1997-04-23 大塚化学株式会社 ペニシラン酸誘導体の製造法
US4958020A (en) * 1989-05-12 1990-09-18 American Cyanamid Company Process for producing β-lactamase inhibitor
JP3233407B2 (ja) * 1993-11-06 2001-11-26 大鵬薬品工業株式会社 結晶性ペニシリン誘導体並びにその製造及び使用
EP1554287B1 (en) 2002-06-07 2006-11-02 Orchid Chemicals and Pharmaceuticals Limited Process for preparation of penam derivatives from cepham derivatives
US7249826B2 (en) * 2004-09-23 2007-07-31 Fujifilm Dimatix, Inc. Soldering a flexible circuit
US20060173177A1 (en) * 2005-01-28 2006-08-03 Gego Csaba L Process for preparation of penam derivatives
SI2046802T1 (sl) * 2006-07-12 2014-03-31 Allecra Therapeutics Gmbh C/O Loeba Treuhand Gmbh 2-substituirani metil penamski derivati
CN102382123A (zh) * 2011-03-10 2012-03-21 海南美好西林生物制药有限公司 一种他唑巴坦钠的制备方法
CN102952148B (zh) * 2011-08-26 2014-11-05 秦引林 一种他唑巴坦钠的精制方法
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274989A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Manufacturing beta-lactam combination products
CN103254214B (zh) * 2013-05-29 2015-06-10 齐鲁天和惠世制药有限公司 一种2β-叠氮甲基青霉烷酸二苯甲酯的制备方法
ES2800603T3 (es) 2013-09-09 2021-01-04 Merck Sharp & Dohme Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019315B2 (ja) * 1976-01-23 1985-05-15 塩野義製薬株式会社 アゼチジノン化合物
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes

Also Published As

Publication number Publication date
NL930140I1 (nl) 1993-12-01
NL930140I2 (nl) 1998-01-05
ES538020A0 (es) 1985-11-01
AU1540383A (en) 1984-01-05
AU541028B2 (en) 1984-12-13
DE3362277D1 (en) 1986-04-03
EP0097446A1 (en) 1984-01-04
ES523701A0 (es) 1985-03-16
ES8600765A1 (es) 1985-11-01
EP0097446B1 (en) 1986-02-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041207