IE43028L - PYRIMIDO [1,2-a] QUINOLINE DERIVATIVES - Google Patents

PYRIMIDO [1,2-a] QUINOLINE DERIVATIVES

Info

Publication number
IE43028L
IE43028L IE760714A IE71476A IE43028L IE 43028 L IE43028 L IE 43028L IE 760714 A IE760714 A IE 760714A IE 71476 A IE71476 A IE 71476A IE 43028 L IE43028 L IE 43028L
Authority
IE
Ireland
Prior art keywords
alkoxy
pyrimido
formula
quinoline
quinoline derivatives
Prior art date
Application number
IE760714A
Other versions
IE43028B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE43028L publication Critical patent/IE43028L/en
Publication of IE43028B1 publication Critical patent/IE43028B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Abstract

1500666 Pyrimido[1,2-a]quinoline - derived amides PFIZER Inc 14 July 1976 [1 Aug 1975] 29181/76 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable cationic salts, wherein R 1 and R 2 are each H, Cl, F or C 1-5 alkyl or alkoxy, or R 1 -R 2 is methylenedioxy or ethylenedioxy, and R 3 is Cl, Br or C 1-5 alkoxy. In examples, the amide link is formed from 5-aminotetrazole and the analogous pyrimidoquinolinecarboxylic acid; the latter is made by hydrolysing the ethyl ester, which is in turn prepared by cyclizing a correspondingly substituted ethyl 2-quinolylaminomethylenemalonate. Additionally, the product in which R 3 is halogen may be converted to one in which R 3 is alkoxy, by reaction with an alkanol. Therapeutic compositions having antiallergy activity comprise compounds of the above formula, and may contain additional active agents such as theophylline or sympathomimetic amines. [GB1500666A]
IE714/76A 1975-08-01 1976-04-06 Substituted pyrimido-quinoline derivatives and pharmaceutical compositions containing them IE43028B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60103975A 1975-08-01 1975-08-01

Publications (2)

Publication Number Publication Date
IE43028L true IE43028L (en) 1977-02-01
IE43028B1 IE43028B1 (en) 1980-12-03

Family

ID=24406004

Family Applications (1)

Application Number Title Priority Date Filing Date
IE714/76A IE43028B1 (en) 1975-08-01 1976-04-06 Substituted pyrimido-quinoline derivatives and pharmaceutical compositions containing them

Country Status (31)

Country Link
JP (1) JPS5231098A (en)
AR (1) AR213099A1 (en)
AT (1) AT351028B (en)
AU (1) AU497412B2 (en)
BE (1) BE843952A (en)
BG (1) BG31229A3 (en)
CA (1) CA1060441A (en)
CH (1) CH616679A5 (en)
CS (1) CS195731B2 (en)
DD (1) DD126735A5 (en)
DE (1) DE2630469C2 (en)
DK (1) DK311276A (en)
EG (1) EG12424A (en)
ES (1) ES449777A1 (en)
FI (1) FI59409C (en)
FR (1) FR2319363A1 (en)
GB (1) GB1500666A (en)
GR (1) GR60549B (en)
HU (1) HU172063B (en)
IE (1) IE43028B1 (en)
IL (1) IL49924A (en)
LU (1) LU75369A1 (en)
NL (1) NL163514C (en)
NO (1) NO139786C (en)
NZ (1) NZ181317A (en)
PH (1) PH12132A (en)
PT (1) PT65349B (en)
SE (1) SE414175B (en)
SU (1) SU685156A3 (en)
YU (1) YU185076A (en)
ZA (1) ZA763876B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720085A1 (en) 1977-05-05 1978-11-16 Hoechst Ag PYRIMIDO (6.1-A) ISOCHINOLIN-2-ON DERIVATIVES
US4127720A (en) * 1977-09-21 1978-11-28 Bristol-Myers Company Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
JPS55138593U (en) * 1979-03-27 1980-10-02
WO1997037999A1 (en) * 1996-04-04 1997-10-16 University Of Nebraska Board Of Regents Synthetic triple helix-forming compounds

Also Published As

Publication number Publication date
CA1060441A (en) 1979-08-14
DE2630469C2 (en) 1982-04-08
IL49924A (en) 1979-03-12
SU685156A3 (en) 1979-09-05
IE43028B1 (en) 1980-12-03
JPS5231098A (en) 1977-03-09
AU1578476A (en) 1978-01-12
CH616679A5 (en) 1980-04-15
BE843952A (en) 1977-01-10
NL163514B (en) 1980-04-15
HU172063B (en) 1978-05-28
PT65349B (en) 1978-01-06
CS195731B2 (en) 1980-02-29
DE2630469A1 (en) 1977-02-17
SE414175B (en) 1980-07-14
AU497412B2 (en) 1978-12-14
NZ181317A (en) 1978-03-06
DK311276A (en) 1977-02-02
IL49924A0 (en) 1976-08-31
GR60549B (en) 1978-06-14
ZA763876B (en) 1977-05-25
LU75369A1 (en) 1977-04-04
PH12132A (en) 1978-11-07
ATA512676A (en) 1978-12-15
BG31229A3 (en) 1981-11-16
NO139786C (en) 1979-05-09
PT65349A (en) 1976-08-01
NL7607618A (en) 1977-02-03
FR2319363A1 (en) 1977-02-25
YU185076A (en) 1982-06-30
DD126735A5 (en) 1977-08-10
EG12424A (en) 1979-03-31
GB1500666A (en) 1978-02-08
NL163514C (en) 1980-09-15
ES449777A1 (en) 1977-08-16
NO762411L (en) 1977-02-02
SE7607099L (en) 1977-02-02
FI59409B (en) 1981-04-30
FI762016A (en) 1977-02-02
AR213099A1 (en) 1978-12-15
FR2319363B1 (en) 1978-11-17
FI59409C (en) 1981-08-10
NO139786B (en) 1979-01-29
AT351028B (en) 1979-07-10

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