ES471779A1 - Procedimiento para la preparacion de derivados de 3-(1-pira-zolil)-piridazina y sus sales de adicion acida - Google Patents
Procedimiento para la preparacion de derivados de 3-(1-pira-zolil)-piridazina y sus sales de adicion acidaInfo
- Publication number
- ES471779A1 ES471779A1 ES471779A ES471779A ES471779A1 ES 471779 A1 ES471779 A1 ES 471779A1 ES 471779 A ES471779 A ES 471779A ES 471779 A ES471779 A ES 471779A ES 471779 A1 ES471779 A1 ES 471779A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydroxyalkyl
- alkyl
- hydrogen atom
- stands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001077 hypotensive effect Effects 0.000 title abstract 2
- SKXBTBMQHHPISZ-UHFFFAOYSA-N 3-pyrazol-1-ylpyridazine Chemical class C1=CC=NN1C1=CC=CN=N1 SKXBTBMQHHPISZ-UHFFFAOYSA-N 0.000 title 1
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la preparación de derivados de 3-(1-pirazolil)-piridazina, de fórmula general I **(Fórmula)** en la cual, R1 representa un átomo de hidrógeno o un grupo alquilo de C1-6, hidroxialquilo de C2-4, cicloalquilo de C3-6, o un grupo fenilo, R2 representa un átomo de hidrógeno, fluor, cloro o bromo, o un grupo alquilo de C1-6, hidroxialquilo de C2-4, un grupo nitro o un grupo -NH5R6, en el cual R5 y R6 pueden tener el mismo significado o un significado diferente, y representar cada uno, un átomo de hidrógeno o un grupo alquilo de C1-4 o hidroxialquilo de C2-4, R3 representa un átomo de hidrógeno o un grupo alquilo de C1-6, hidroxialquilo de C2-4, cicloalquilo de C3-6, o un grupo fenilo, un átomo de cloro, o un grupo hidróxilo, amino o metoxi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU77GO1381A HU176100B (en) | 1977-10-25 | 1977-10-25 | Process for preparing new 3-/1-pyrazolyl/-pyridazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471779A1 true ES471779A1 (es) | 1979-10-01 |
Family
ID=10996838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471779A Expired ES471779A1 (es) | 1977-10-25 | 1978-07-15 | Procedimiento para la preparacion de derivados de 3-(1-pira-zolil)-piridazina y sus sales de adicion acida |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4224325A (es) |
| JP (1) | JPS5461187A (es) |
| AT (1) | AT359076B (es) |
| AU (1) | AU525814B2 (es) |
| BE (1) | BE868987A (es) |
| CA (1) | CA1090337A (es) |
| CH (1) | CH637951A5 (es) |
| CS (1) | CS217964B2 (es) |
| DD (1) | DD139848A5 (es) |
| DE (1) | DE2831072A1 (es) |
| DK (1) | DK317678A (es) |
| ES (1) | ES471779A1 (es) |
| FI (1) | FI63397C (es) |
| FR (1) | FR2407211A1 (es) |
| GB (1) | GB2007644B (es) |
| HU (1) | HU176100B (es) |
| IL (1) | IL55120A (es) |
| IT (1) | IT1097156B (es) |
| NL (1) | NL7807572A (es) |
| NO (1) | NO149354C (es) |
| PL (2) | PL118799B1 (es) |
| SE (1) | SE437988B (es) |
| SU (3) | SU847920A3 (es) |
| YU (1) | YU169878A (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302457A (en) * | 1977-04-13 | 1981-11-24 | The Upjohn Company | Process for therapeutic treatment |
| US4302456A (en) * | 1977-04-13 | 1981-11-24 | The Upjohn Company | Process for therapeutic treatment |
| DE2935359A1 (de) * | 1979-09-01 | 1981-03-26 | Basf Ag, 67063 Ludwigshafen | 6-imidazolyl-3-hydrazino-pyridazine |
| US4304775A (en) * | 1979-12-13 | 1981-12-08 | Sterling Drug Inc. | 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof |
| US4503056A (en) * | 1982-03-02 | 1985-03-05 | Abbott Laboratories | 1-(Pyridazinyl)pyrazoline derivatives |
| US5001125A (en) * | 1984-03-26 | 1991-03-19 | Janssen Pharmaceutica N.V. | Anti-virally active pyridazinamines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1220428B (de) | 1960-03-25 | 1966-07-07 | Takeda Pharmaceutical | Verfahren zur Herstellung von 2-Pyrazolyl-(1')-pyrimidinderivaten und deren Salzen |
| JPS5831347B2 (ja) * | 1975-09-05 | 1983-07-05 | 中外製薬株式会社 | ピラゾリルピリダジンユウドウタイノ セイホウ |
| HU175471B (hu) * | 1977-06-13 | 1980-08-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh proizvodnykh 3-skobka-1-pirazolil-skobka zakryta-piridazina |
-
1977
- 1977-10-25 HU HU77GO1381A patent/HU176100B/hu unknown
-
1978
- 1978-07-11 CS CS784648A patent/CS217964B2/cs unknown
- 1978-07-11 US US05/923,623 patent/US4224325A/en not_active Expired - Lifetime
- 1978-07-11 IL IL55120A patent/IL55120A/xx unknown
- 1978-07-13 FR FR7820938A patent/FR2407211A1/fr active Granted
- 1978-07-13 AU AU37997/78A patent/AU525814B2/en not_active Expired
- 1978-07-13 AT AT509278A patent/AT359076B/de not_active IP Right Cessation
- 1978-07-13 FI FI782237A patent/FI63397C/fi not_active IP Right Cessation
- 1978-07-13 SE SE7807822A patent/SE437988B/sv unknown
- 1978-07-14 YU YU01698/78A patent/YU169878A/xx unknown
- 1978-07-14 NL NL7807572A patent/NL7807572A/xx not_active Application Discontinuation
- 1978-07-14 DE DE19782831072 patent/DE2831072A1/de not_active Withdrawn
- 1978-07-14 CH CH764178A patent/CH637951A5/de not_active IP Right Cessation
- 1978-07-14 PL PL1978218031A patent/PL118799B1/pl unknown
- 1978-07-14 NO NO782446A patent/NO149354C/no unknown
- 1978-07-14 DD DD78206732A patent/DD139848A5/de unknown
- 1978-07-14 BE BE189273A patent/BE868987A/xx not_active IP Right Cessation
- 1978-07-14 DK DK317678A patent/DK317678A/da not_active Application Discontinuation
- 1978-07-14 CA CA307,397A patent/CA1090337A/en not_active Expired
- 1978-07-14 GB GB7829820A patent/GB2007644B/en not_active Expired
- 1978-07-14 SU SU782639448A patent/SU847920A3/ru active
- 1978-07-14 PL PL1978208409A patent/PL115063B1/pl unknown
- 1978-07-14 IT IT25681/78A patent/IT1097156B/it active
- 1978-07-15 ES ES471779A patent/ES471779A1/es not_active Expired
- 1978-07-15 JP JP8569878A patent/JPS5461187A/ja active Granted
-
1979
- 1979-08-23 SU SU792804755A patent/SU856385A3/ru active
- 1979-08-23 SU SU792803900A patent/SU845786A3/ru active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA05007496A (es) | Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes. | |
| IL161559A0 (en) | Dibenzylamine derivatives and pharmaceutical compositions containing the same | |
| HUP0102723A2 (hu) | Új difenilkarbamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények | |
| ES8203883A1 (es) | Un procedimiento para la preparacion de derivados de imida- zol | |
| NO20071198L (no) | N-(1H-indolyl)-1H-indol-2-karboksamidderivater, deres fremstilling og terapeutiske anvendelse | |
| ES8203845A1 (es) | Procedimiento para preparar derivados de piridoxina | |
| NO20001402L (no) | Substituerte kromanderivater | |
| SE8301412L (sv) | Substituerade 1h-pyrazolo(1,5)pyrimidiner och forfarande for deras framstellning | |
| MXPA05007494A (es) | Nuevos compuestos. | |
| ATE296300T1 (de) | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
| NO932998L (no) | Nye 4,5-dihydro-4-okso-pyrrolo(1,2-a) kinoksaliner og tilsvarende aza-analoger of fremgangsmaate for fremstilling av dem | |
| ES470750A1 (es) | Procedimiento de preparacion de nuevos derivados de 3-(1-pi-razolil)-piridazina y de sus sales farmaceuticamente acepta-bles | |
| ES471779A1 (es) | Procedimiento para la preparacion de derivados de 3-(1-pira-zolil)-piridazina y sus sales de adicion acida | |
| HUP9903758A2 (hu) | Benzoxazinon dopamin D4 receptor antagonisták és az ezeket tartalmazó gyógyszerkészítmények | |
| ES456039A1 (es) | Procedimiento para preparar derivados de indolizina. | |
| ES8707927A1 (es) | Procedimiento para preparar nuevas pirrolidinonas substituidas | |
| SE7703068L (sv) | Nya sulfonamido-bensoesyraderivat jemte sett for deras framstellning | |
| CA2085796A1 (en) | 3(2h)-pyridazinone derivatives and process for the preparation thereof | |
| MY130687A (en) | Process for the preparation of mesylates of piperazine derivatives | |
| ES8502093A1 (es) | Derivados de quinolina. | |
| HUP9900679A2 (hu) | Simaizom sejtburjánzást gátló benzimidazolszármazékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| RS50085B (sr) | Novi derivati morfolina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže | |
| ATE261441T1 (de) | Analoga von distamycin-zimtsäurederivaten, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
| DE3371511D1 (en) | Quinoline derivatives | |
| EA200101172A1 (ru) | Противогрибковые эфиры |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19851002 |