NO932998L - Nye 4,5-dihydro-4-okso-pyrrolo(1,2-a) kinoksaliner og tilsvarende aza-analoger of fremgangsmaate for fremstilling av dem - Google Patents

Nye 4,5-dihydro-4-okso-pyrrolo(1,2-a) kinoksaliner og tilsvarende aza-analoger of fremgangsmaate for fremstilling av dem

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Publication number
NO932998L
NO932998L NO932998A NO932998A NO932998L NO 932998 L NO932998 L NO 932998L NO 932998 A NO932998 A NO 932998A NO 932998 A NO932998 A NO 932998A NO 932998 L NO932998 L NO 932998L
Authority
NO
Norway
Prior art keywords
preparation
quinoxalines
pyrrolo
dihydro
oxo
Prior art date
Application number
NO932998A
Other languages
English (en)
Other versions
NO932998D0 (no
Inventor
Hans-Reinhold Dieter
Jurgen Engel
Karl-Heinz Klingler
Bernhard Kutscher
Stefan Szelenyi
Ute Achterrath-Tuckermann
Jurgen Schmidt
Peter Metzenauer
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of NO932998D0 publication Critical patent/NO932998D0/no
Publication of NO932998L publication Critical patent/NO932998L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det blir beskrevet nye forbindelser med formelen: hvor fenylringen istedenfor en CH-gruppe også kan inneholde et nitrogenatom, R1 står for C2-C6-alkenyl, Cjr-Cfc-alkinyl, hydroksy, Cj-C^-alkoksy, Cg-Ct- alkenyloksy, Cg-C^-alkinyloksy, Cjr-C^-alkanoyloksy, benzoyloksy, morfolino- karbonyloksy, C^-C^-alkyloksykarbonyloksy, C^-C^-alkylaminokarbonyloksy, C^-C^-dialkylaminokarbonyloksy eller gruppen -Alk-A, hvor Alk står for f1' Cj-Cfc-alkyl, Cg-Cfc-hydroksyalkyl eller Cg-C^-cykloalkyl og symbolet A står for hydrogen eller andre substituenter. R2- R3 °& R4 st^r for forskjellige substituenter hvor hydrogen, når R£ er gruppen: også kan være Rc-N N-CH2-CH-CH2-0- OH og R5 er fenyl, C1-C4-alkoksyfenyl eller difenylmetyl Og R3 og R4 er hydrogen, og deres salter. Dessuten blir det beskrevet en fremgangsmåte for fremstilling av utgangsstoffer for fremstilling av forbindelser med formel (I).
NO932998A 1992-08-24 1993-08-23 Nye 4,5-dihydro-4-okso-pyrrolo(1,2-a) kinoksaliner og tilsvarende aza-analoger of fremgangsmaate for fremstilling av dem NO932998L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4228095A DE4228095A1 (de) 1992-08-24 1992-08-24 Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
NO932998D0 NO932998D0 (no) 1993-08-23
NO932998L true NO932998L (no) 1994-02-25

Family

ID=6466304

Family Applications (1)

Application Number Title Priority Date Filing Date
NO932998A NO932998L (no) 1992-08-24 1993-08-23 Nye 4,5-dihydro-4-okso-pyrrolo(1,2-a) kinoksaliner og tilsvarende aza-analoger of fremgangsmaate for fremstilling av dem

Country Status (18)

Country Link
US (1) US5405847A (no)
EP (1) EP0584487A3 (no)
JP (1) JPH06184155A (no)
KR (1) KR940003957A (no)
CN (1) CN1088928A (no)
AU (1) AU661408B2 (no)
BR (1) BR9303456A (no)
CA (1) CA2104653A1 (no)
CZ (1) CZ170693A3 (no)
DE (1) DE4228095A1 (no)
FI (1) FI933705A (no)
HU (1) HUT70165A (no)
IL (1) IL106761A0 (no)
MX (1) MX9305092A (no)
NO (1) NO932998L (no)
PH (1) PH30110A (no)
SK (1) SK89693A3 (no)
ZA (1) ZA936169B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DE19510965A1 (de) * 1995-03-24 1996-09-26 Asta Medica Ag Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
EP1312363A1 (en) * 2001-09-28 2003-05-21 Pfizer Products Inc. Methods of treatment and kits comprising a growth hormone secretagogue
US7550459B2 (en) 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
EP1461318B9 (en) 2001-12-28 2005-12-28 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
JP5496680B2 (ja) * 2006-12-28 2014-05-21 アッヴィ・インコーポレイテッド ポリ（ａｄｐ−リボース）ポリメラーゼの阻害剤
AU2010206744B2 (en) * 2009-01-23 2015-08-20 Takeda Pharmaceutical Company Limited Poly (ADP-ribose) polymerase (PARP) inhibitors
JP5715625B2 (ja) 2009-07-30 2015-05-07 武田薬品工業株式会社 ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
EP2648754A4 (en) * 2010-12-07 2016-02-24 Philadelphia Health & Educatio METHODS OF INHIBITING THE METASTASIS OF CANCER
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
JP2023530089A (ja) 2020-06-11 2023-07-13 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチンチンタンパク質をイメージングするための複素環式化合物及びイメージング剤
CN114560862A (zh) * 2022-03-08 2022-05-31 山东龙辰药业有限公司 一种吡咯并[1,2-a]喹喔啉-4(5h)-酮及其衍生物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576077A (en) * 1977-04-13 1980-10-01 Roussel Lab Ltd 4,5-dihydro-4-oxophyrrolo(1,2-)-quinoxaline-2-carboxylic acids and derivatives
GB2043637B (en) * 1979-02-09 1983-03-16 Roussel Lab Ltd Heterotricyclic derivatives
US4440929A (en) * 1981-07-16 1984-04-03 Usv Pharmaceutical Corporation Imidazoquinoxaline compounds
US4446323A (en) * 1983-05-23 1984-05-01 American Home Products Corporation Tetra- and hexa-hydropyrrolo(1,2-a)quinoxaline and azaquinoxaline derivatives
IL90315A0 (en) * 1988-06-01 1989-12-15 Ferrosan As Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
DK626288D0 (da) * 1988-11-10 1988-11-10 Ferrosan As Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
PH30110A (en) 1996-12-27
NO932998D0 (no) 1993-08-23
ZA936169B (en) 1994-03-17
EP0584487A3 (en) 1994-07-06
BR9303456A (pt) 1994-03-22
HU9302397D0 (en) 1993-11-29
FI933705A0 (fi) 1993-08-23
HUT70165A (en) 1995-09-28
KR940003957A (ko) 1994-03-14
CN1088928A (zh) 1994-07-06
FI933705A (fi) 1994-02-25
US5405847A (en) 1995-04-11
MX9305092A (es) 1994-02-28
CZ170693A3 (en) 1994-03-16
AU661408B2 (en) 1995-07-20
IL106761A0 (en) 1993-12-08
JPH06184155A (ja) 1994-07-05
CA2104653A1 (en) 1994-02-25
DE4228095A1 (de) 1994-03-03
SK89693A3 (en) 1994-03-09
EP0584487A2 (de) 1994-03-02
AU4483393A (en) 1994-03-03

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