ES453101A1 - Metodo de preparar una cinamamida. - Google Patents
Metodo de preparar una cinamamida.Info
- Publication number
- ES453101A1 ES453101A1 ES453101A ES453101A ES453101A1 ES 453101 A1 ES453101 A1 ES 453101A1 ES 453101 A ES453101 A ES 453101A ES 453101 A ES453101 A ES 453101A ES 453101 A1 ES453101 A1 ES 453101A1
- Authority
- ES
- Spain
- Prior art keywords
- convulsant
- cinnamide compounds
- compounds
- cinnamide
- convulsions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 229960003965 antiepileptics Drugs 0.000 title 1
- APEJMQOBVMLION-VOTSOKGWSA-N trans-cinnamamide Chemical class NC(=O)\C=C\C1=CC=CC=C1 APEJMQOBVMLION-VOTSOKGWSA-N 0.000 title 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- APEJMQOBVMLION-UHFFFAOYSA-N cinnamamide Chemical class NC(=O)C=CC1=CC=CC=C1 APEJMQOBVMLION-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
Abstract
La presente invención se refiere a productos químicos que tienen valiosas propiedades farmacológicas. En particular, la invenciones refiere a cinamamidas, sus síntesis, preparaciones farmacéuticas que las contiene, y su uso en medicina. Se ha hallado que las cinamamidas de fórmula (I), tiene actividad anticonvulsiva en mamíferos, como se muestra por sus efectos sobre ratones cuando se les administra en ensayos farmacológicas establecidos. En la fórmula (I) **(Fórmula)** X es cloro, bromo o yodo, y R es hidrógeno o alcohilo que tiene 1 a 3 átomos de carbono. Se prefiere la configuración trans de los compuestos de fórmula (I); y el compuesto en el que R es etilo y X es bromo tiene una actividad anticolvulsiva extraordinaria, en ambos ensayos farmacológicos antes descritos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB35279/74A GB1519762A (en) | 1974-08-09 | 1974-08-09 | Cinnamamides their preparation and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ES453101A1 true ES453101A1 (es) | 1978-03-01 |
Family
ID=10375925
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES440140A Expired ES440140A1 (es) | 1974-08-09 | 1975-08-08 | Metodo de preparar una cinamamida. |
ES453101A Expired ES453101A1 (es) | 1974-08-09 | 1976-11-06 | Metodo de preparar una cinamamida. |
ES453100A Expired ES453100A1 (es) | 1974-08-09 | 1976-11-06 | Metodo de preparar una cinamamida. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES440140A Expired ES440140A1 (es) | 1974-08-09 | 1975-08-08 | Metodo de preparar una cinamamida. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES453100A Expired ES453100A1 (es) | 1974-08-09 | 1976-11-06 | Metodo de preparar una cinamamida. |
Country Status (27)
Country | Link |
---|---|
US (1) | US4041071A (es) |
JP (1) | JPS588387B2 (es) |
AR (2) | AR213275A1 (es) |
AT (2) | AT350531B (es) |
AU (1) | AU498222B2 (es) |
BE (1) | BE832283A (es) |
CA (1) | CA1075714A (es) |
CH (3) | CH616650A5 (es) |
CS (1) | CS209864B2 (es) |
CY (1) | CY1110A (es) |
DD (1) | DD123311A5 (es) |
DE (1) | DE2535599C2 (es) |
DK (1) | DK360975A (es) |
ES (3) | ES440140A1 (es) |
FI (1) | FI752257A (es) |
FR (1) | FR2281109A1 (es) |
GB (1) | GB1519762A (es) |
HK (1) | HK20881A (es) |
HU (1) | HU174875B (es) |
IE (1) | IE41444B1 (es) |
IL (1) | IL47892A (es) |
IT (1) | IT8047984A0 (es) |
NL (1) | NL7509482A (es) |
PL (5) | PL110755B1 (es) |
SE (1) | SE424316B (es) |
SU (1) | SU728712A3 (es) |
ZA (1) | ZA755127B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190674A (en) * | 1976-02-03 | 1980-02-26 | Burroughs Wellcome Co. | 3-Fluoro-N-cyclopropylcinnamide |
US4107320A (en) * | 1976-08-06 | 1978-08-15 | Burroughs Wellcome Co. | Biologically active amides |
US4183858A (en) * | 1977-07-01 | 1980-01-15 | Merrell Toraude Et Compagnie | α-Vinyl tryptophanes |
US4179524A (en) * | 1978-06-16 | 1979-12-18 | Burroughs Wellcome Co. | Biologically active amide |
DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
KR100492809B1 (ko) * | 2001-11-23 | 2005-06-03 | 한국화학연구원 | 항산화 활성을 갖는 4-히드록시 신남아미드 유도체, 그의제조방법 및 이를 포함하는 약학적 조성물 |
PL209602B1 (pl) | 2005-10-20 | 2011-09-30 | Inst Chemii Bioorg Pan | Sposób otrzymywania amidu kwasu 3-(4-hydroksyfenylo)propanowego |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1131728A (en) | 1966-05-10 | 1968-10-23 | Smith Kline French Lab | N,n-dimethylcinnamamides |
GB1128142A (en) | 1966-06-30 | 1968-09-25 | James Lincoln Bezemek | Wear indicating arrangement for vehicle power transfer devices |
US3444197A (en) | 1966-09-27 | 1969-05-13 | Upjohn Co | 3,4-dihalocinnamamides |
US3538156A (en) | 1967-07-24 | 1970-11-03 | Herbert Schwartz | Cinnamamides |
CH533113A (de) * | 1967-12-01 | 1973-03-15 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Zimtsäureamiden |
US3488749A (en) * | 1968-01-29 | 1970-01-06 | Smithkline Corp | Antidepressant n,n-dimethylcinnamamide compositions and methods |
CH510019A (de) | 1968-11-05 | 1971-07-15 | Thomae Gmbh Dr K | Verfahren zur Herstellung neuer Zimtsäureamide |
FR2040181A1 (es) * | 1969-04-02 | 1971-01-22 | Lipha | |
CA1174865A (en) | 1971-04-16 | 1984-09-25 | Ferenc M. Pallos | Thiolcarbamate herbicides containing nitrogen containing antidote |
-
1974
- 1974-08-09 GB GB35279/74A patent/GB1519762A/en not_active Expired
-
1975
- 1975-07-17 US US05/596,653 patent/US4041071A/en not_active Expired - Lifetime
- 1975-08-08 AR AR259950A patent/AR213275A1/es active
- 1975-08-08 FR FR7524783A patent/FR2281109A1/fr active Granted
- 1975-08-08 PL PL1975201097A patent/PL110755B1/pl unknown
- 1975-08-08 DE DE2535599A patent/DE2535599C2/de not_active Expired
- 1975-08-08 PL PL1975182629A patent/PL101781B1/pl unknown
- 1975-08-08 AU AU83789/75A patent/AU498222B2/en not_active Expired
- 1975-08-08 AT AT618175A patent/AT350531B/de not_active IP Right Cessation
- 1975-08-08 IL IL47892A patent/IL47892A/xx unknown
- 1975-08-08 CH CH1039275A patent/CH616650A5/de not_active IP Right Cessation
- 1975-08-08 IE IE1760/75A patent/IE41444B1/en unknown
- 1975-08-08 JP JP50096600A patent/JPS588387B2/ja not_active Expired
- 1975-08-08 SU SU752163175A patent/SU728712A3/ru active
- 1975-08-08 FI FI752257A patent/FI752257A/fi not_active Application Discontinuation
- 1975-08-08 PL PL1975217609A patent/PL118238B1/pl unknown
- 1975-08-08 DK DK360975A patent/DK360975A/da unknown
- 1975-08-08 ES ES440140A patent/ES440140A1/es not_active Expired
- 1975-08-08 SE SE7508936A patent/SE424316B/xx unknown
- 1975-08-08 CA CA233,157A patent/CA1075714A/en not_active Expired
- 1975-08-08 HU HU75WE526A patent/HU174875B/hu unknown
- 1975-08-08 NL NL7509482A patent/NL7509482A/xx not_active Application Discontinuation
- 1975-08-08 PL PL1975217610A patent/PL118454B1/pl unknown
- 1975-08-08 ZA ZA755127A patent/ZA755127B/xx unknown
- 1975-08-08 BE BE159078A patent/BE832283A/xx unknown
- 1975-08-08 DD DD187766A patent/DD123311A5/xx unknown
- 1975-08-08 CS CS755508A patent/CS209864B2/cs unknown
- 1975-08-08 PL PL1975201096A patent/PL101758B1/pl unknown
- 1975-11-07 CY CY1110A patent/CY1110A/xx unknown
-
1976
- 1976-11-06 ES ES453101A patent/ES453101A1/es not_active Expired
- 1976-11-06 ES ES453100A patent/ES453100A1/es not_active Expired
-
1977
- 1977-02-01 AT AT61977A patent/AT346314B/de not_active IP Right Cessation
- 1977-08-04 AR AR264203A patent/AR211436Q/es unknown
-
1979
- 1979-12-10 CH CH1093979A patent/CH639067A5/de not_active IP Right Cessation
- 1979-12-10 CH CH1093879A patent/CH636339A5/de not_active IP Right Cessation
-
1980
- 1980-02-22 IT IT8047984A patent/IT8047984A0/it unknown
-
1981
- 1981-05-14 HK HK208/81A patent/HK20881A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES470789A1 (es) | Un procedimiento para la preparacion de una composicion limpiadora cosmetica | |
ES437996A1 (es) | Procedimiento de preparacion de derivados poliyodados del benceno. | |
ES451954A1 (es) | Un procedimiento para la preparacion de una composicion de- tergente granulada a pulverulenta. | |
ES431055A1 (es) | Procedimiento para la preparacion de nuevos n- (metoximetil-furilmetil)-6, 7-benzomorfanos y -morfinanos. | |
ES436160A1 (es) | Procedimiento para preparar 1, 1-diaril-1-oxadiazol-alquila-minas. | |
ES436955A1 (es) | Procedimiento para el lavado, la limpieza o el blanqueo. | |
ES405983A1 (es) | Procedimiento para la preparacion de derivados de fenileti-lamina fluoralcohilados. | |
SE7602144L (sv) | Kvaternera imidazoliumforeningar | |
ES453101A1 (es) | Metodo de preparar una cinamamida. | |
ES8403863A1 (es) | Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico. | |
ES436715A1 (es) | Metodo para la preparacion de un nuevo compuesto herbicida. | |
ES432288A1 (es) | Procedimiento para preparar derivados de ergopectina. | |
ES440395A1 (es) | Procedimiento para la produccion de esteres de acidos piri- midiniltionofosfonicos. | |
ES440723A1 (es) | Procedimiento para la produccion de nuevos compuestos orga- nicos. | |
ES438430A1 (es) | Procedimiento para la preparacion de acidos arilalcanoicos conteniendo anillos dihidrofutanicos o dihodropiranicos. | |
ES449068A1 (es) | Procedimiento para preparar derivados de isoxazol. | |
ES466682A1 (es) | Procedimiento para la obtencion de derivados del acido inde-no - 2.1-b-tiopen-2-oxamico | |
ES464150A1 (es) | Procedimiento para la preparacion de compuestos derivados defenil-amino-2-imidazolina | |
ES457405A1 (es) | Procedimiento de preparacion de compuestos opacificantes. | |
JPS5545677A (en) | 4*55methanoobufadienolideerhamnoside*its manufacture and medicine containing it | |
ES454307A1 (es) | Procedimiento para la preparacion de nuevos derivados de ci-clopentano. | |
ES446329A1 (es) | Un procedimiento de preparacion de nuevas acetamidoximas. | |
ES8403922A1 (es) | "procedimiento para preparar nuevos esteres de acido tiolfosforico" | |
ES453057A1 (es) | Procedimiento para preparar derivados de imidazolidindiona. | |
ES441564A1 (es) | Procedimiento para la preparacion de nuevos acidos fenil al-cano sustituidos y sus derivados. |