ES8403863A1 - Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico. - Google Patents

Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico.

Info

Publication number
ES8403863A1
ES8403863A1 ES522984A ES522984A ES8403863A1 ES 8403863 A1 ES8403863 A1 ES 8403863A1 ES 522984 A ES522984 A ES 522984A ES 522984 A ES522984 A ES 522984A ES 8403863 A1 ES8403863 A1 ES 8403863A1
Authority
ES
Spain
Prior art keywords
acids
halogenobenzhydrylsulfinylacetohydroxamic
preparation
therapeutical use
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522984A
Other languages
English (en)
Other versions
ES522984A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of ES8403863A1 publication Critical patent/ES8403863A1/es
Publication of ES522984A0 publication Critical patent/ES522984A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ACIDO HALOGENOBENZHIDRILSULFINILACETOHIDROXAMICO, DE FORMULA GENERAL (I), EN LA QUE X1 REPRESENTA F, CL, BR O CF3; Y X2 REPRESENTA H, F, CL, BR O CF3.CONSISTE EN HACER REACCIONAR UN HALOGENOBENZHIDRILTIOACETATO DE ALQUILO, DE FORMULA (II), EN LA QUE X1 Y X2 TIENEN LOS SIGNIFICADOS YA INDICADOS; Y R REPRESENTA UN GRUPO ALQUILO DE C1-C2, CON HIDROXILAMINA EN CANTIDADES ESTEQUIOMETRICAS EN PRESENCIA DE NA, NAOH O KOH Y EN UN ALCOHOL, PARA OBTENER EL ACIDO HALOGENO-BENZHIDRILTIOACET OHIDROXAMICO, DE FORMULA (III), Y A CONTINUACION SE SOMETE DICHO ACIDO ASI OBTENIDO AUNA REACCION DE OXIDACION POR MEDIO DE H2O2, EN ACIDO ACETICO.DE APLICACION EN TERAPEUTICA, EN PARTICULAR COMO SUSTANCIAS ACTIVAS SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES522984A 1982-06-04 1983-06-03 Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico. Granted ES522984A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8209805A FR2528041A1 (fr) 1982-06-04 1982-06-04 Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique

Publications (2)

Publication Number Publication Date
ES8403863A1 true ES8403863A1 (es) 1984-03-01
ES522984A0 ES522984A0 (es) 1984-03-01

Family

ID=9274666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522984A Granted ES522984A0 (es) 1982-06-04 1983-06-03 Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico.

Country Status (10)

Country Link
US (1) US4489095A (es)
EP (1) EP0097547B1 (es)
JP (1) JPS591458A (es)
AT (1) ATE15186T1 (es)
CA (1) CA1192222A (es)
DE (1) DE3360669D1 (es)
DK (1) DK157810C (es)
ES (1) ES522984A0 (es)
FR (1) FR2528041A1 (es)
IE (1) IE54977B1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2602768B1 (fr) * 1986-08-13 1989-02-03 Lafon Labor Derives de l'acide 2-(4,4'-difluoro benzhydryl thio) acetique, leurs procedes de preparation et leurs applications en therapeutique
FR2606015B1 (fr) * 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
JP2521595B2 (ja) * 1991-07-04 1996-08-07 江崎グリコ株式会社 精白粳米菓の製造方法
US5571825A (en) * 1995-03-31 1996-11-05 Warner-Lambert Company Method of selectively inhibiting prostaglandin G/H synthase-2
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
BR9807803A (pt) * 1997-02-27 2000-02-22 American Cyanamid Co N-hidróxi-2-(alquil, aril ou heteroaril sulfanil, sulfinil ou sulfonil) -alquila, arila ou heteroarilamidas 3-substituìdas como inibidores da metaloproteinase matricial
US6492396B2 (en) 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
EP1437345A1 (en) * 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
CA2511992A1 (en) * 2003-02-24 2004-09-10 Mallinckrodt Inc. Process for preparing benzhydrylthioacetamide
DK2649187T3 (da) 2010-12-08 2018-01-29 Codexis Inc Biokatalysatorer og fremgangsmåder til syntesen af armodafinil
FR2970711B1 (fr) 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
CN104059004A (zh) * 2014-06-25 2014-09-24 江苏斯威森生物医药工程研究中心有限公司 一种2-[(4,4’-二卤-二苯基甲基)巯基]乙酸酯的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2483671A (en) * 1947-06-02 1949-10-04 Parke Davis & Co Aminoalkyl benzhydryl thioethers and their preparation
US2618637A (en) * 1950-03-18 1952-11-18 Sterling Drug Inc Tertiary - aminoalkyl diarylmethyl sulfones and their preparation
US3157650A (en) * 1962-09-04 1964-11-17 Cilag Chemie Amides of 2-aryl-ethanoic acids
GB1121027A (en) * 1966-06-23 1968-07-24 Ici Ltd New carboxylic acid derivatives, processes for the preparation thereof and compositions containing the same
US3789072A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
AT336589B (de) * 1974-05-20 1977-05-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen biphenylderivaten
US4156011A (en) * 1974-09-30 1979-05-22 Societe Anonyme Dite: Laboratoire L. Lafon Sulphur- and oxygen-containing diaryl compounds
FR2285859A1 (fr) * 1974-09-30 1976-04-23 Lafon Labor Phenylsulfinyl-amidines et derives
GB1520812A (en) * 1975-10-02 1978-08-09 Lafon Labor Benzhydrylsulphinyl derivatives
DE2546319C2 (de) * 1975-10-16 1986-02-27 Dr. Karl Thomae Gmbh, 7950 Biberach Cyclohexylphenyl-Derivate, Verfahren zu deren Herstellung und diese enthaltende Mittel
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
US4183927A (en) * 1976-08-16 1980-01-15 The Dow Chemical Company Substituted phenylthioalkylamines and compositions thereof
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
US4199597A (en) * 1979-05-04 1980-04-22 Schering Corporation Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio)alkanoic acids and compounds related thereto
FR2502617B1 (es) * 1981-03-25 1984-04-27 Lafon Labor

Also Published As

Publication number Publication date
JPS6136829B2 (es) 1986-08-20
EP0097547B1 (fr) 1985-08-28
DK157810B (da) 1990-02-19
JPS591458A (ja) 1984-01-06
IE831193L (en) 1983-12-04
ATE15186T1 (de) 1985-09-15
FR2528041B1 (es) 1985-02-08
US4489095A (en) 1984-12-18
IE54977B1 (en) 1990-04-11
DK253383D0 (da) 1983-06-03
EP0097547A1 (fr) 1984-01-04
FR2528041A1 (fr) 1983-12-09
CA1192222A (en) 1985-08-20
DK157810C (da) 1990-07-09
DK253383A (da) 1983-12-05
DE3360669D1 (en) 1985-10-03
ES522984A0 (es) 1984-03-01

Similar Documents

Publication Publication Date Title
ES8406472A1 (es) Procedimiento para preparar imidazolilalquiltien-2-il-tetrahidropiridazinas
ES8404332A1 (es) Procedimiento para preparar acidos omega-(1,4,5-trifenilimidazol-2-iloxi)-alcanicos
ES8403863A1 (es) Procedimiento de preparacion de un acido halogenobenzhidrilsulfinilacetohidroxamico.
AU633142B2 (en) Pyrimidine-4,6-dicarboxylic acid diamides, processes for their preparation and the use thereof, and pharmaceuticals based on these compounds
ES8103083A1 (es) Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas
ES8401960A1 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
ES8500226A1 (es) Un procedimiento de preparacion de imino-2-pirrolidinas.
ES8106276A1 (es) Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico
BE862459A (fr) Procede pour l'amelioration des produits tensio-actifs fluores
BE884848A (fr) Sel mixte d'acide valproique utile notamment pour le traitement de l'epilepsie, presentant des caracteristiques tres superieures de stabilite
YU104289A (en) Process for making new three-iodine benzen compounds with unionic iodine and contrast products containing them
ES8302669A1 (es) "procedimiento de preparacion de nuevos derivados, solubles, n2 sustituidos de la diamino-2,4-bencil-5-pirimidina".
ES8504807A1 (es) Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano (2, 3-c) piridinas
FR2502617B1 (es)
FR2426665A1 (fr) Hydrocarbures halogenes utiles notamment comme composes intermediaires pour pesticides et leur procede de production
ES8607344A1 (es) Procedimiento para la homopolimerizacion y copolimerizacion de compuestos susceptibles de iniciacion anionica
AU569982B2 (en) N-(4-acetylaminophenacyl)-amines
IE820760L (en) 4-phenoxy-3-hydroxy-butyramidoxime derivatives
JPS56128770A (en) N-amino-5-fluorouracil and its preparation
GR76240B (es)

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20031222