ES8404332A1 - Procedimiento para preparar acidos omega-(1,4,5-trifenilimidazol-2-iloxi)-alcanicos - Google Patents

Procedimiento para preparar acidos omega-(1,4,5-trifenilimidazol-2-iloxi)-alcanicos

Info

Publication number
ES8404332A1
ES8404332A1 ES524512A ES524512A ES8404332A1 ES 8404332 A1 ES8404332 A1 ES 8404332A1 ES 524512 A ES524512 A ES 524512A ES 524512 A ES524512 A ES 524512A ES 8404332 A1 ES8404332 A1 ES 8404332A1
Authority
ES
Spain
Prior art keywords
acids
triphenylimidazolyloxyalcanoic
derivatives
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524512A
Other languages
English (en)
Other versions
ES524512A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of ES8404332A1 publication Critical patent/ES8404332A1/es
Publication of ES524512A0 publication Critical patent/ES524512A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

PROCEDIMIENTO PARA PREPARAR ACIDOS OMEGA-(1,4,5-TRIFENILI MIDAZOL-2-ILOXI)-ALCANOICOS Y SUS DERIVADOS DE LA FORMULA GENERAL (I), EN LA QUE N ES UN NUMERO ENTERO COMPRENDIDO ENTRE 1 Y 10;R, R, R, R, R Y R, PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO, HALOGENO, ALQUILO, ALQUILOXI O TRIFLUOROMETILO; Y R SIGNIFICA HIDROGENO, UN ION DE METAL ALCALINO O UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA CON 1 A 6 ATOMOS DE CARBONO.CONSISTE EN HACER REACCIONAR UNA 4-IMIDAZOLIN-2-ONA, DE FORMULA GENERAL (II), EN LA QUE R, R, R, R, R Y R TIENEN LOS SIGNIFICADOS YA MENCIONADOS, EN UNDISOLVENTE ORGANICO ADECUADO, CON UN AGENTE DE ALQUILACION DE FORMULA GENERAL (III), EN LA QUE N Y R TIENEN LOS SIGNIFICADOS YA INDICADOS.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES TROMBOEMBOLICAS, INFLAMATORIAS, ATEROSCLEROTICAS Y RELACIONADAS CON EL METABOLISMO DE LIPIDOS.
ES524512A 1982-07-29 1983-07-28 Procedimiento para preparar acidos omega-(1,4,5-trifenilimidazol-2-iloxi)-alcanicos Granted ES524512A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3228271A DE3228271A1 (de) 1982-07-29 1982-07-29 Triphenylimidazolyloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES8404332A1 true ES8404332A1 (es) 1984-04-16
ES524512A0 ES524512A0 (es) 1984-04-16

Family

ID=6169571

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524512A Granted ES524512A0 (es) 1982-07-29 1983-07-28 Procedimiento para preparar acidos omega-(1,4,5-trifenilimidazol-2-iloxi)-alcanicos

Country Status (13)

Country Link
US (1) US4460598A (es)
EP (1) EP0104342B1 (es)
JP (1) JPS5951269A (es)
AT (1) ATE25246T1 (es)
DE (2) DE3228271A1 (es)
DK (1) DK158723C (es)
ES (1) ES524512A0 (es)
FI (1) FI79302C (es)
GR (1) GR78654B (es)
IE (1) IE55485B1 (es)
NO (1) NO160579C (es)
PT (1) PT77125B (es)
ZA (1) ZA834648B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3323870A1 (de) * 1983-07-02 1985-01-03 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazol-2-ylthioalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4598149A (en) * 1984-03-02 1986-07-01 Merck & Co., Inc. 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents
DE3504679A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Amide der 2-imidazolyloxyalkansaeuren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3504677A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazol-2-yloxyalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3504680A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue ether des 2-hydroxyimidazols, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3504678A1 (de) * 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung
JPH0680057B2 (ja) * 1986-04-28 1994-10-12 保土谷化学工業株式会社 トリフエニルイミダゾ−ル及びその二量体
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
US4900744A (en) * 1988-09-14 1990-02-13 E. I. Du Pont De Nemours And Company Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles
US5166214A (en) * 1988-12-05 1992-11-24 Du Pont Merck Pharmaceutical Company Use of imidazoles for the treatment of atherosclerosis
CA2014537A1 (en) * 1989-04-26 1990-10-26 Yoshio Hayashi 4-imidazoline derivatives
US5019572A (en) * 1990-02-07 1991-05-28 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US4994482A (en) * 1989-07-31 1991-02-19 Bristol-Myers Squibb Company Arylpyrazol derivatives as anti-platelet agents, compositions and use
US5262540A (en) * 1989-12-20 1993-11-16 Bristol-Myers Squibb Company [2(4,5-diaryl-2 oxazoyl substituted phenoxy alkanoic acid and esters
US5152988A (en) * 1990-02-07 1992-10-06 Merck & Co., Inc. Imidazole compounds in compositions and methods in thrombolytic therapy
CA2036192A1 (en) 1990-02-13 1991-08-14 Nicholas Meanwell Heterocyclic carboxylic acids and esters
US5011851A (en) * 1990-02-13 1991-04-30 Bristol-Myers Squibb Co. Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
GB9019838D0 (en) * 1990-09-11 1990-10-24 Smith Kline French Lab Compounds
US5428041A (en) * 1991-05-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Antihypercholesterolemic bis-trifluoromethyl-substituted imidazolines and derivatives thereof
US5179117A (en) * 1991-12-20 1993-01-12 Du Pont Merck Pharmaceutical Company Antihypercholesterolemic 2-substituted imidazoles
KR100291112B1 (ko) * 1992-02-11 2001-09-17 더 존스 홉킨스 유니버시티 코엔자임에이-독립성트랜스아실라제및혈소판활성화인자억제제
US5254576A (en) * 1992-04-03 1993-10-19 Bristol-Myers Squibb Company Diphenyl-heterocyclic-oxazole as platelet aggregation inhibitors
US5187188A (en) * 1992-04-03 1993-02-16 Bristol-Myers Squibb Company Oxazole carboxylic acid derivatives
US5348969A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5362879A (en) * 1993-04-15 1994-11-08 Bristol-Myers Squibb Company 4-5-diphenyloxazole derivatives as inhibitors of blood platelet aggregation
SE527381C3 (sv) * 2003-04-14 2006-03-21 Linnman Elektronik Ab Gemensam fältbuss för överföring av data och energi

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636003A (en) * 1969-11-17 1972-01-18 Geigy Chem Corp Substituted 2-mercaptoimidazole derivatives
DE2934746A1 (de) * 1979-08-28 1981-03-19 A. Nattermann & Cie GmbH, 5000 Köln Oxoimidazolinalkansaeuren, deren salze und ester sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2950478A1 (de) * 1979-12-14 1981-06-19 A. Nattermann & Cie GmbH, 5000 Köln 4,5-diaryl-4-imidazolin-2-on-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3042466A1 (de) * 1980-11-11 1982-06-16 A. Nattermann & Cie GmbH, 5000 Köln N-substituierte (omega) -(2-oxo-4-imidazolin-l-yl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
ZA834648B (en) 1984-03-28
NO832630L (no) 1984-01-30
PT77125A (en) 1983-08-01
EP0104342A1 (de) 1984-04-04
IE831483L (en) 1983-12-29
DK158723C (da) 1990-12-10
NO160579B (no) 1989-01-23
EP0104342B1 (de) 1987-01-28
JPH0456030B2 (es) 1992-09-07
US4460598A (en) 1984-07-17
DK346783A (da) 1984-01-30
DE3228271A1 (de) 1984-02-02
FI832730A (fi) 1984-01-30
ES524512A0 (es) 1984-04-16
DK346783D0 (da) 1983-07-28
ATE25246T1 (de) 1987-02-15
FI832730A0 (fi) 1983-07-28
JPS5951269A (ja) 1984-03-24
FI79302B (fi) 1989-08-31
DK158723B (da) 1990-07-09
DE3369508D1 (en) 1987-03-05
NO160579C (no) 1989-05-03
GR78654B (es) 1984-09-27
PT77125B (en) 1986-01-24
FI79302C (fi) 1989-12-11
IE55485B1 (en) 1990-09-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401