ES8302669A1 - "procedimiento de preparacion de nuevos derivados, solubles, n2 sustituidos de la diamino-2,4-bencil-5-pirimidina". - Google Patents

"procedimiento de preparacion de nuevos derivados, solubles, n2 sustituidos de la diamino-2,4-bencil-5-pirimidina".

Info

Publication number
ES8302669A1
ES8302669A1 ES510618A ES510618A ES8302669A1 ES 8302669 A1 ES8302669 A1 ES 8302669A1 ES 510618 A ES510618 A ES 510618A ES 510618 A ES510618 A ES 510618A ES 8302669 A1 ES8302669 A1 ES 8302669A1
Authority
ES
Spain
Prior art keywords
diamino
substituted derivatives
soluble
pyrimidines
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510618A
Other languages
English (en)
Other versions
ES510618A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panmedica SA
Original Assignee
Panmedica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panmedica SA filed Critical Panmedica SA
Publication of ES8302669A1 publication Critical patent/ES8302669A1/es
Publication of ES510618A0 publication Critical patent/ES510618A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS SOLUBLES N , SUSTITUIDOS, DE LA DIAMINO-2,4-BENCIL-5-PIRIMIDINA, DE FORMULA (I), EN LA QUE Y, R, R , R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN DERIVADO DE DIAMINO-2,4-BENCIL-5-PIRIMIDINA CON UNA CANTIDAD ESTEQUIOMETRICA DE UN ALDEHIDO Y UN EXCESO DE ANHIDRIDO SULFUROSO, EN UN DISOLVENTE TAL COMO LA PIRIDINA. EL PRODUCTO OBTENIDO SE AISLA POR DILUCION CON ETER O UN HIDROCARBURO Y SE PURIFICA LAVANDOLO CON ALCOHOL. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBACTERIANOS.
ES510618A 1981-03-20 1982-03-20 "procedimiento de preparacion de nuevos derivados, solubles, n2 sustituidos de la diamino-2,4-bencil-5-pirimidina". Granted ES510618A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8105592A FR2502152A1 (fr) 1981-03-20 1981-03-20 Nouveaux derives solubles n2 substitues de la diamino-2,4-benzyl-5-pyrimidines, leur procede de preparation et medicaments les contenant

Publications (2)

Publication Number Publication Date
ES8302669A1 true ES8302669A1 (es) 1983-02-01
ES510618A0 ES510618A0 (es) 1983-02-01

Family

ID=9256463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510618A Granted ES510618A0 (es) 1981-03-20 1982-03-20 "procedimiento de preparacion de nuevos derivados, solubles, n2 sustituidos de la diamino-2,4-bencil-5-pirimidina".

Country Status (13)

Country Link
US (1) US4415574A (es)
EP (1) EP0061397B1 (es)
JP (1) JPS57169472A (es)
AT (1) ATE17483T1 (es)
AU (1) AU555274B2 (es)
CA (1) CA1180015A (es)
DE (2) DE61397T1 (es)
ES (1) ES510618A0 (es)
FR (1) FR2502152A1 (es)
GR (1) GR75938B (es)
MA (1) MA19413A1 (es)
OA (1) OA07044A (es)
ZA (1) ZA821785B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
EP1438053B1 (de) * 2001-10-17 2008-09-10 Boehringer Ingelheim Pharma GmbH & Co.KG Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung
CN1930135B (zh) * 2004-03-05 2011-12-28 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3拮抗剂的二氨基嘧啶
JP4850913B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３及びｐ２ｘ２／３調節因子としてのジアミノピリジン
BRPI0615613A2 (pt) * 2005-09-01 2009-05-19 Hoffmann La Roche diaminopirimidinas como moduladores de p2x3 e p3x2/3
JP4850911B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン
JP6788524B2 (ja) * 2017-02-28 2020-11-25 ダイコク電機株式会社 遊技用装置及び遊技場システム

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1407971A (en) * 1971-04-16 1975-10-01 Wellcome Found 2,4-diamino -4-3,4,5-triethoxybenzyl pyrimidine and methods of preparation therefor
FR2358148A1 (fr) * 1976-07-12 1978-02-10 Dick Pr Derives de 2,4-diaminopyrimidines et leur mise en solution en association avec des sulfamides
FR2397407A2 (fr) * 1977-07-11 1979-02-09 Dick Pierre Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides

Also Published As

Publication number Publication date
GR75938B (es) 1984-08-02
EP0061397A1 (fr) 1982-09-29
FR2502152B1 (es) 1984-01-20
ES510618A0 (es) 1983-02-01
ATE17483T1 (de) 1986-02-15
JPS57169472A (en) 1982-10-19
EP0061397B1 (fr) 1986-01-15
CA1180015A (en) 1984-12-27
AU8172882A (en) 1982-09-23
FR2502152A1 (fr) 1982-09-24
OA07044A (fr) 1983-12-31
DE61397T1 (de) 1983-10-13
JPH0340026B2 (es) 1991-06-17
AU555274B2 (en) 1986-09-18
US4415574A (en) 1983-11-15
DE3268481D1 (en) 1986-02-27
MA19413A1 (fr) 1982-10-01
ZA821785B (en) 1983-02-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612