ES478342A1 - Procedimiento para la obtencion de nuevos compuestos de urea y amido. - Google Patents

Procedimiento para la obtencion de nuevos compuestos de urea y amido.

Info

Publication number
ES478342A1
ES478342A1 ES478342A ES478342A ES478342A1 ES 478342 A1 ES478342 A1 ES 478342A1 ES 478342 A ES478342 A ES 478342A ES 478342 A ES478342 A ES 478342A ES 478342 A1 ES478342 A1 ES 478342A1
Authority
ES
Spain
Prior art keywords
urea
preparation
pharmaceutical compositions
amide derivatives
preparing pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478342A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES478342A1 publication Critical patent/ES478342A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la obtención de nuevos compuestos de urea y amido de fórmula **(Fórmula)** donde R1 y R3 significan un arilo monocíclico, carbocíclico, ó heteroarilo, n representa 0 ó 1, m es 0, 1 ó 2, p es 1 ó 2, R2 significa un átomo de hidrógeno ó alquilo inferior, Alk significa un grupo alquileno inferior, con 2-3 átomos en la línea de cadena, X significa oxígeno, ó azufre e Y es el grupo imino ó un enlace directo, y sus sales, caracterizado porquea)un compuesto de fórmula general II **(Fórmula)** se hace reaccionar con un derivado reactivo del ácido de fórmula general III **(Fórmula)** donde X, Y y R3 tienen los significados arriba indicados, ó b) un compuesto de fórmula general VI **(Fórmula)** donde Rl, R2, n y m tienen los significados arriba indicados, se hace reaccionar con un derivado de dietilen ó bien dipropilentriamina de fórmula general VII**(Fórmula)**donde p. X, Y, Alk y R3 tienen el significado arriba indicado, y en un compuesto obtenido de fórmula general I,encaso deseado, y dentro del márgen de la definición delos productos finales, se introducen, modifican o disocian los sustituyentes, y/o las mezclas de racemato obtenidas se separan en los racematos puros, y/o los racematos obtenidos se separan en los antípodas ópticos, y/o las sales obtenidas se transforman en los compuestos libres o en otras sales, o los compuestos libres en sus sales.
ES478342A 1978-03-08 1979-03-06 Procedimiento para la obtencion de nuevos compuestos de urea y amido. Expired ES478342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH251978 1978-03-08

Publications (1)

Publication Number Publication Date
ES478342A1 true ES478342A1 (es) 1979-05-16

Family

ID=4235609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478342A Expired ES478342A1 (es) 1978-03-08 1979-03-06 Procedimiento para la obtencion de nuevos compuestos de urea y amido.

Country Status (28)

Country Link
US (2) US4292429A (es)
EP (1) EP0004561B1 (es)
JP (1) JPS54125668A (es)
KR (2) KR820002098B1 (es)
AR (2) AR225010A1 (es)
AT (1) AT364375B (es)
AU (1) AU531006B2 (es)
CS (1) CS244656B2 (es)
CY (1) CY1304A (es)
DD (1) DD142336A5 (es)
DE (1) DE2961198D1 (es)
DK (1) DK95279A (es)
ES (1) ES478342A1 (es)
FI (1) FI70708C (es)
GB (1) GB2016011B (es)
GR (1) GR71998B (es)
HK (1) HK80185A (es)
HU (1) HU182940B (es)
IL (1) IL56797A (es)
MY (1) MY8700199A (es)
NO (1) NO152606C (es)
NZ (1) NZ189841A (es)
OA (1) OA06201A (es)
PH (1) PH16207A (es)
PL (2) PL116762B1 (es)
PT (1) PT69314A (es)
SU (2) SU845779A3 (es)
ZA (1) ZA791062B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338453A (en) 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
US4353921A (en) * 1981-06-19 1982-10-12 Berlex Laboratories, Inc. Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
AU5234886A (en) * 1984-12-12 1986-07-01 MTD-Produkter I Smaland A.B. Method of preparing a hospital room or the like
GB8906198D0 (en) * 1989-03-17 1989-05-04 Ciba Geigy Ag Compounds
EP1879870A1 (en) * 2005-05-03 2008-01-23 Pharma Mar, S.A. Antitumoral tetrahydro-pyrimidines
FR2901273B1 (fr) * 2006-05-19 2010-12-24 Anaconda Pharma Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
US8215871B2 (en) 2008-09-17 2012-07-10 William Kingston Tideway anchor system
KR101493717B1 (ko) * 2010-03-04 2015-02-16 아지노모토 가부시키가이샤 알킬아민 유도체
JP5761173B2 (ja) 2010-03-04 2015-08-12 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
CN102924380B (zh) * 2012-11-13 2014-12-31 齐鲁动物保健品有限公司 一种咪唑苯脲的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH234990A (de) * 1938-05-11 1944-10-31 Chem Ind Basel Verfahren zur Darstellung eines neuen therapeutisch wirksamen Amidins.
GB813525A (en) * 1956-07-09 1959-05-21 Socony Mobil Oil Co Inc Fuel oil composition
GB1082964A (en) * 1963-06-25 1967-09-13 Wellcome Found New substituted imidazolines and their preparation and use
US3455940A (en) * 1965-12-07 1969-07-15 Herbert C Stecker Certain halo and dihalo n-substituted salicylamides
GB1174349A (en) * 1966-08-25 1969-12-17 Boehringer Sohn Ingelheim Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof
US3846071A (en) * 1969-02-12 1974-11-05 Petrolite Corp Process of inhibiting corrosion by treatment with phosphate-cyclic amidine salts
NL7415845A (nl) * 1973-12-26 1975-06-30 Upjohn Co Werkwijze voor het bevorderen van de productie van endogene prostaglandinen door zoogdieren, alsmede werkwijze ter bereiding van daarbij te gebruiken preparaten.
US4088766A (en) * 1975-06-25 1978-05-09 The Upjohn Company Urea containing compositions and methods
US4233451A (en) * 1976-05-20 1980-11-11 The Procter & Gamble Company Process for making imidazolinium salts
US4353921A (en) * 1981-06-19 1982-10-12 Berlex Laboratories, Inc. Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use

Also Published As

Publication number Publication date
IL56797A (en) 1982-09-30
GB2016011A (en) 1979-09-19
ZA791062B (en) 1980-03-26
SU845779A3 (ru) 1981-07-07
PT69314A (de) 1979-04-01
CS244656B2 (en) 1986-08-14
HK80185A (en) 1985-10-25
EP0004561B1 (de) 1981-11-04
CY1304A (en) 1985-12-06
MY8700199A (en) 1987-12-31
SU923367A3 (ru) 1982-04-23
FI70708C (fi) 1986-10-06
NO152606C (no) 1985-10-23
GB2016011B (en) 1982-08-25
KR830000884B1 (ko) 1983-04-26
ATA171079A (de) 1981-03-15
DK95279A (da) 1979-09-09
AR227286A1 (es) 1982-10-15
US4420619A (en) 1983-12-13
GR71998B (es) 1983-08-26
HU182940B (en) 1984-03-28
AU531006B2 (en) 1983-08-04
AR225010A1 (es) 1982-02-15
OA06201A (fr) 1981-06-30
KR820002098B1 (ko) 1982-11-05
US4292429A (en) 1981-09-29
JPS629109B2 (es) 1987-02-26
FI70708B (fi) 1986-06-26
DE2961198D1 (en) 1982-01-14
PL116762B1 (en) 1981-06-30
FI790740A (fi) 1979-09-09
AT364375B (de) 1981-10-12
AU4490079A (en) 1979-09-13
DD142336A5 (de) 1980-06-18
NZ189841A (en) 1982-03-09
NO152606B (no) 1985-07-15
PL213924A1 (es) 1980-02-25
NO790765L (no) 1979-09-11
EP0004561A2 (de) 1979-10-17
PL123150B1 (en) 1982-09-30
PH16207A (en) 1983-08-05
EP0004561A3 (en) 1979-11-14
JPS54125668A (en) 1979-09-29

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