ES479410A1 - Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico. - Google Patents
Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico.Info
- Publication number
- ES479410A1 ES479410A1 ES479410A ES479410A ES479410A1 ES 479410 A1 ES479410 A1 ES 479410A1 ES 479410 A ES479410 A ES 479410A ES 479410 A ES479410 A ES 479410A ES 479410 A1 ES479410 A1 ES 479410A1
- Authority
- ES
- Spain
- Prior art keywords
- antihypertensive
- pyridyl derivatives
- thiazolidinecarboxylic
- acids
- thiazolidinecarboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Un procedimiento para la preparación de derivados del ácido 4-tiazolidincarboxilico de fórmula-01 (I): **(Fórmula-01)** donde R1 es mercaptoalquilo inferior, acilmercapto-alquilo inferior, alquilo superior, cicloalquilo, aralquilo, fenilo, furilo, tienilo, piridilo, naftilo, alquilo superior sustituido, cicloalquilo sustituido, aralquilo sustituido, fenilo sustituido, furilo sustituido, tienilo sustituido, piridilo sustituido o naftilo sustituido, donde el o los sustituyentes son alquilo inferior, hidroxi, mercapto, alcoxi inferior, alquilendioxi inferior, aciloxi, acilmercapto, halógeno, nitro, amino, alquilamino inferior, acilamino o carboxi; R2 es hidrógeno o benzoilo; A es alquileno lineal o ramificado de 1 a 3 átomos de carbono; y sales del mismo, cuyo procedimiento comprende: a) hacer reaccionar un ácido de fórmula-02 (II): **(Fórmula-02)** donde R3 es acilmercapto alquilo inferior, alquilo superior, cicloalquilo, aralquilo, fenilo, furilo, tienilo, piridilo, naftilo, alquilo superiorsustituido, cicloalquilo sustituido, aralquilo sustituido, fenilo sustituido, furilo sustituido, tienilo sustituido, piridilo sustituido o naftilo sustituido, donde el o los sustituyentes son alquilo inferior, hidroxi, alcoxi inferior, alquilendioxi inferior, aciloxi, acilmercapto, halógeno, nitro, alquilamino inferior, acilamino o carboxi, con un compuesto de fórmula: Z - A - CO - Y, donde A es alquileno lineal o ramificado de 1 a 3 átomos de carbono e Y es hidroxi o halógeno, Z es R4 - S - o halógeno, y R4 es benzoilo o bencilo; b) cuando Z es halógeno, hacer reaccionar el producto obtenido en la etapa anterior con un compuesto de fórmula: M - SH, donde M es bencilo o benzoilo; y c) opcionalmente hidrolizar o reducir los compuestos obtenidos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4163278A JPS54135768A (en) | 1978-04-08 | 1978-04-08 | Thiazolidine derivative |
JP4965778A JPS54148783A (en) | 1978-04-25 | 1978-04-25 | Thiazolidine derivative |
JP8111678A JPS557255A (en) | 1978-07-03 | 1978-07-03 | Thiazolidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479410A1 true ES479410A1 (es) | 1980-08-16 |
Family
ID=27290900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479410A Expired ES479410A1 (es) | 1978-04-08 | 1979-04-06 | Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico. |
Country Status (11)
Country | Link |
---|---|
US (5) | US4430344A (es) |
AU (1) | AU528115B2 (es) |
CA (1) | CA1127157A (es) |
CH (1) | CH649293A5 (es) |
DE (1) | DE2914059C2 (es) |
ES (1) | ES479410A1 (es) |
FR (1) | FR2421889A1 (es) |
GB (1) | GB2018248B (es) |
IT (1) | IT1115158B (es) |
NL (1) | NL7902710A (es) |
SE (1) | SE434943B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA794723B (en) * | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
JPS56139455A (en) | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
JPS5756425A (en) * | 1980-09-20 | 1982-04-05 | Santen Pharmaceut Co Ltd | Hypotensor |
JPS57112381A (en) * | 1980-12-29 | 1982-07-13 | Santen Pharmaceut Co Ltd | Five-membered heterocyclic compound |
DE3152643A1 (de) * | 1980-12-29 | 1982-12-16 | Santen Pharmaceutical Co Ltd | Heterocyclic 5-membered ring compounds |
JPS57142962A (en) * | 1981-02-28 | 1982-09-03 | Santen Pharmaceut Co Ltd | Cyclodextrin clathrate compound of sulfur-containing compound |
DE3134933A1 (de) * | 1981-09-03 | 1983-03-31 | Hoechst Ag, 6230 Frankfurt | "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung" |
IT1153963B (it) * | 1982-03-22 | 1987-01-21 | Montedison Spa | Derivati dell'acido 2 0 4-tiazolidin-carbossilico 3-acil sostituiti ad azione fitoregolatrice e biostimolanti |
IT1191109B (it) * | 1982-12-03 | 1988-02-24 | Simes | Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono |
US4631343A (en) * | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
GB2164333B (en) * | 1984-07-27 | 1988-11-16 | Boehringer Biochemia Srl | Antitussive and mucus regulating 2-substituted thiazolidines |
IT1196485B (it) * | 1986-07-14 | 1988-11-16 | Zambon Spa | Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica |
CN1030415A (zh) * | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
IT1241415B (it) * | 1990-03-05 | 1994-01-14 | Yason Srl | Derivato dell'acido s-(2-tenoil)-tiolattico ad attivita' farmacologica |
CA2178130C (en) * | 1995-06-05 | 2002-04-02 | Hiroshi Ikawa | Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative |
US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
CA2344913A1 (en) * | 1998-09-21 | 2000-03-30 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
AU2003263948A1 (en) * | 2002-08-22 | 2004-03-11 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US7687468B2 (en) * | 2003-05-14 | 2010-03-30 | Viacell, LLC. | Rejuvenation of stored blood |
AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
CA2680592C (en) * | 2007-03-15 | 2016-07-05 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof in treating pathological conditions |
CA2859406C (en) | 2011-12-16 | 2020-08-25 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
RU2526619C2 (ru) * | 2012-12-12 | 2014-08-27 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Способ получения (2r,4r)-2-алкил-3-(2-меркаптобензоил)-1,3-тиазолидин-4-карбоновых кислот |
EP3071201A4 (en) | 2013-11-22 | 2017-04-26 | University of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
EP3288557A4 (en) | 2015-04-27 | 2018-11-07 | University of Florida Research Foundation, Inc. | Metabolically programmed metal chelators and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3592905A (en) * | 1969-10-30 | 1971-07-13 | Merck & Co Inc | Therapeutic methods |
FR2356423A1 (fr) * | 1976-07-01 | 1978-01-27 | Oeriu Simion | Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments |
US4192878A (en) | 1976-12-03 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Derivatives of thiazolidinecarboxylic acids and related acids |
AU518147B2 (en) * | 1976-12-03 | 1981-09-17 | E.R. Squibb & Sons, Inc. | Derivatives of thiazolidine, thiazine and morpholine carboxylic acids |
JPS5834474B2 (ja) | 1977-06-29 | 1983-07-27 | ウェルファイド株式会社 | チアゾリジン誘導体の製造法 |
FR2395998A1 (fr) | 1977-06-29 | 1979-01-26 | Yoshitomi Pharmaceutical | Nouveaux derives de la thiazolidine et leur application dans le traitement de l'hypertension |
JPS6047264B2 (ja) * | 1977-08-15 | 1985-10-21 | ウェルファイド株式会社 | チアゾリジン誘導体 |
FR2404635A1 (fr) * | 1977-09-28 | 1979-04-27 | Science Union & Cie | Nouveaux thioproprionylamides, leurs procedures d'obtention et leur emploi en therapeutique |
US4282235A (en) * | 1978-05-22 | 1981-08-04 | E. R. Squibb & Sons, Inc. | Derivatives of thiazolidinecarboxylic acids and related acids |
US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
US4374249A (en) * | 1980-12-23 | 1983-02-15 | American Cyanamid Company | [4R]-3-(ω-Aroylpropionyl)-4-thiazolidinecarboxylic acids and esters |
-
1979
- 1979-03-23 US US05/023,397 patent/US4430344A/en not_active Expired - Lifetime
- 1979-03-23 AU AU45444/79A patent/AU528115B2/en not_active Ceased
- 1979-04-02 SE SE7902910A patent/SE434943B/sv not_active IP Right Cessation
- 1979-04-03 GB GB7911642A patent/GB2018248B/en not_active Expired
- 1979-04-05 CH CH3226/79A patent/CH649293A5/de not_active IP Right Cessation
- 1979-04-06 CA CA325,022A patent/CA1127157A/en not_active Expired
- 1979-04-06 DE DE2914059A patent/DE2914059C2/de not_active Expired
- 1979-04-06 ES ES479410A patent/ES479410A1/es not_active Expired
- 1979-04-06 IT IT21666/79A patent/IT1115158B/it active
- 1979-04-06 FR FR7908829A patent/FR2421889A1/fr active Granted
- 1979-04-06 NL NL7902710A patent/NL7902710A/xx not_active Application Discontinuation
-
1981
- 1981-03-02 US US06/239,600 patent/US4423054A/en not_active Expired - Fee Related
- 1981-03-02 US US06/239,599 patent/US4457935A/en not_active Expired - Fee Related
- 1981-03-02 US US06/239,602 patent/US4356183A/en not_active Expired - Fee Related
- 1981-03-02 US US06/239,601 patent/US4386096A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1127157A (en) | 1982-07-06 |
FR2421889B1 (es) | 1982-11-19 |
NL7902710A (nl) | 1979-10-10 |
IT7921666A0 (it) | 1979-04-06 |
CH649293A5 (de) | 1985-05-15 |
US4423054A (en) | 1983-12-27 |
DE2914059C2 (de) | 1984-09-06 |
IT1115158B (it) | 1986-02-03 |
DE2914059A1 (de) | 1979-10-25 |
SE434943B (sv) | 1984-08-27 |
FR2421889A1 (fr) | 1979-11-02 |
US4386096A (en) | 1983-05-31 |
GB2018248A (en) | 1979-10-17 |
US4430344A (en) | 1984-02-07 |
AU528115B2 (en) | 1983-04-14 |
SE7902910L (sv) | 1979-10-09 |
AU4544479A (en) | 1979-10-18 |
GB2018248B (en) | 1982-10-27 |
US4356183A (en) | 1982-10-26 |
US4457935A (en) | 1984-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |