ES8106276A1 - Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico - Google Patents

Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico

Info

Publication number
ES8106276A1
ES8106276A1 ES494230A ES494230A ES8106276A1 ES 8106276 A1 ES8106276 A1 ES 8106276A1 ES 494230 A ES494230 A ES 494230A ES 494230 A ES494230 A ES 494230A ES 8106276 A1 ES8106276 A1 ES 8106276A1
Authority
ES
Spain
Prior art keywords
acid amides
treating liver
liver dysfunction
amides useful
polyprenylcarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494230A
Other languages
English (en)
Other versions
ES494230A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP10274779A external-priority patent/JPS5626852A/ja
Priority claimed from JP10866879A external-priority patent/JPS5632442A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES494230A0 publication Critical patent/ES494230A0/es
Publication of ES8106276A1 publication Critical patent/ES8106276A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE AMIDAS DEL ACIDO POLIPRENILCARBOXILICO, DE FORMULA (I), EN LA QUE "N" VALE DE 1 A 4; "A", "B", "C" Y "D" SON ATOMOS DE HIDROGENO O CADA PAR "A-B", "C-D" REPRESENTA UN ENLACE DE VALENCIA ENTRE LOS ATOMOS DE CARBONO A LOS QUE ESTAN UNIDOS, Y R1 Y R2 SON ATOMOS DE HIDROGENO, RADICAL ALQUILO INFERIOR, FENILO O FENILO SUSTITUIDO O FORMAN, UNIDOS, UN HETEROCICLO DE CINCO O SEIS ESLABONES. CUANDO "C-D" REPRESENTA UN ENLACE DE VALENCIA, EL COMPUESTO DE FORMULA (I) SE OBTIENE POR REACCION DE UN COMPUESTO DE FORMULA (II), CON UN REACTIVO DE WITTIG, DE FORMULA (III), EN LAS QUE X ES UN ATOMO DE HALOGENO Y "N", "A", "B", R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO POR UN METODO CONVENCIONAL. SI "C" Y "D" SON ATOMOS DE HIDROGENO, EL COMPUESTO DE FORMULA (I) SE PUEDE OBTENER POR REDUCCION DEL PRODUCTO RESULTANTE DE LA REACCION DE WITTIG, ANTERIOR, CON BOROHIDRURO SODICO Y UN HALURO METALICO, O POR REACCION DE UN COMPUESTO DE FORMULA (IV) OUN DERIVADO REACTIVO DEL MISMO CON UNA AMINA DE FORMULA R1NHR2. *FORMULA*
ES494230A 1979-08-14 1980-08-13 Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico Expired ES8106276A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10274779A JPS5626852A (en) 1979-08-14 1979-08-14 Alpha,beta-dihydropolyprenylcarbonamide
JP10866879A JPS5632442A (en) 1979-08-28 1979-08-28 Polyprenylcarboxylic acid amide

Publications (2)

Publication Number Publication Date
ES494230A0 ES494230A0 (es) 1981-08-01
ES8106276A1 true ES8106276A1 (es) 1981-08-01

Family

ID=26443426

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494230A Expired ES8106276A1 (es) 1979-08-14 1980-08-13 Un procedimiento para la preparacion de amidas del acido po-liprenilcarboxilico

Country Status (12)

Country Link
US (2) US4456603A (es)
AU (1) AU531466B2 (es)
CA (1) CA1148153A (es)
CH (1) CH644582A5 (es)
DE (1) DE3030462A1 (es)
ES (1) ES8106276A1 (es)
FR (2) FR2463122A1 (es)
GB (1) GB2058782B (es)
IT (1) IT1132406B (es)
NL (1) NL8004609A (es)
PH (1) PH16234A (es)
SE (2) SE446977B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5899490A (ja) * 1981-10-19 1983-06-13 Eisai Co Ltd リン酸アミド誘導体およびその製造方法ならびにそれを含有する医薬
US4564477A (en) * 1982-02-19 1986-01-14 Kuraray Co., Ltd. Polyprenyl compounds and method of producing the same
JPS58177953A (ja) * 1982-04-13 1983-10-18 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法
JPS591474A (ja) * 1982-06-07 1984-01-06 Nippon Iyakuhin Kogyo Kk ピペラジン環を有するゲラニルゲラニル酢酸アミド化合物またはその塩類
JPS59101448A (ja) * 1982-11-30 1984-06-12 Eisai Co Ltd ポリプレニルカルボン酸アミドおよびその製造方法ならびにそれを含有する医薬
JPS59152354A (ja) * 1983-02-21 1984-08-31 Nisshin Flour Milling Co Ltd イソプレニル酸アミド誘導体
JPS6122054A (ja) * 1984-05-09 1986-01-30 Eisai Co Ltd ポリプレニル系化合物
FI865097A (fi) * 1985-12-17 1987-06-18 Wellcome Found Pesticida foereningar.
DE3913940A1 (de) * 1989-04-27 1990-10-31 Bayer Ag N-formyl-n'-((meth)acryloyloxyalkyl)piperazin und n-formyl-n'-((meth)acryloylaminoalkyl)piperazin, adhaesivkomponenten zur behandlung kollagenhaltiger materialien, enthaltend diese verbindungen, sowie herstellung und anwendung dieser adhaesivkomponenten
US5254733A (en) * 1990-10-31 1993-10-19 Fujisawa Pharmaceutical Co., Ltd. Process for producing an aliphatic amide and salts thereof
CA2362494A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP2840077A1 (en) * 2013-08-20 2015-02-25 DSM IP Assets B.V. Process for the manufacture of hydrogenated nitriles
US20220135514A1 (en) * 2019-02-21 2022-05-05 Hagihara Farm Production Institute Co., Ltd. Cancer cell growth inhibiting composition and processed food

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147261A (en) * 1962-05-24 1964-09-01 Robert R Mod Nu-acyl-nu'-methylpiperazines
US3621043A (en) * 1963-02-06 1971-11-16 Sumitomo Chemical Co N-substituted octadecadienoic acid amides as cholesterol lowering agents
US3270033A (en) * 1963-02-25 1966-08-30 Evald L Skau Nu-oleoylpyrrolidine
US3294794A (en) * 1963-12-19 1966-12-27 Raiford L Holmes 4-(2-alkenoyl, or 2 bromoalkanoyl) morpholines
US3404145A (en) * 1965-04-13 1968-10-01 Agriculture Usa N-acyl derivatives of cyclic imines
GB1209902A (en) * 1966-09-15 1970-10-21 Zoecon Corp Long chain hydrocarbon phosphonates and processes for their preparation
CH508613A (de) * 1967-12-18 1971-06-15 Hoffmann La Roche Verfahren zur Herstellung von Epoxyverbindungen
AU1648870A (en) * 1969-07-09 1971-12-23 Fmc Corporation Method of controlling insects and compostion therefor
US3649590A (en) * 1969-09-02 1972-03-14 Zoecon Corp Quaternary alkylated aliphatic amides
US3773805A (en) * 1971-05-03 1973-11-20 J Siddall 11-halo-3,7,11-trialkyl-2-alkenoic and 2,6-alkadienoic acid amides
JPS52131507A (en) * 1976-04-24 1977-11-04 Sankyo Co Ltd Polyprenyl derivatives

Also Published As

Publication number Publication date
CA1148153A (en) 1983-06-14
US4456603A (en) 1984-06-26
SE8005712L (sv) 1981-02-15
ES494230A0 (es) 1981-08-01
US4639450A (en) 1987-01-27
AU531466B2 (en) 1983-08-25
PH16234A (en) 1983-08-11
IT8024157A0 (it) 1980-08-14
FR2463122B1 (es) 1983-06-17
GB2058782B (en) 1983-06-08
FR2463122A1 (fr) 1981-02-20
NL8004609A (nl) 1981-02-17
SE446977B (sv) 1986-10-20
SE8404308D0 (sv) 1984-08-29
SE8404308L (sv) 1984-08-29
FR2497802B1 (es) 1985-01-18
AU6134280A (en) 1981-02-19
CH644582A5 (fr) 1984-08-15
DE3030462C2 (es) 1989-10-05
DE3030462A1 (de) 1981-03-19
GB2058782A (en) 1981-04-15
FR2497802A1 (fr) 1982-07-16
IT1132406B (it) 1986-07-02

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