ES2941663T3 - Reactivos zwitteriónicos - Google Patents

Reactivos zwitteriónicos Download PDF

Info

Publication number
ES2941663T3
ES2941663T3 ES11784156T ES11784156T ES2941663T3 ES 2941663 T3 ES2941663 T3 ES 2941663T3 ES 11784156 T ES11784156 T ES 11784156T ES 11784156 T ES11784156 T ES 11784156T ES 2941663 T3 ES2941663 T3 ES 2941663T3
Authority
ES
Spain
Prior art keywords
zwitterion
heteroatoms
compound
containing compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11784156T
Other languages
English (en)
Spanish (es)
Inventor
Anand Natrajan
David Sharpe
David Wen
Qingping Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Application granted granted Critical
Publication of ES2941663T3 publication Critical patent/ES2941663T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ES11784156T 2010-05-21 2011-05-18 Reactivos zwitteriónicos Active ES2941663T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34692610P 2010-05-21 2010-05-21
PCT/US2011/036971 WO2011146595A2 (en) 2010-05-21 2011-05-18 Zwitterionic reagents

Publications (1)

Publication Number Publication Date
ES2941663T3 true ES2941663T3 (es) 2023-05-24

Family

ID=44992311

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11784156T Active ES2941663T3 (es) 2010-05-21 2011-05-18 Reactivos zwitteriónicos

Country Status (6)

Country Link
US (2) US9487480B2 (enExample)
EP (2) EP2571487B1 (enExample)
JP (2) JP2013534909A (enExample)
CN (1) CN102905690B (enExample)
ES (1) ES2941663T3 (enExample)
WO (1) WO2011146595A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008019381A1 (en) 2006-08-07 2008-02-14 University Of Washington Mixed charge copolymers and hydrogels
US9487480B2 (en) * 2010-05-21 2016-11-08 Siemens Healthcare Diagnostics Inc. Zwitterionic reagents
WO2016025752A1 (en) * 2014-08-14 2016-02-18 Prolynx Llc Reagents for thiol conjugation and conjugates formed therefrom
US9943816B2 (en) 2014-10-20 2018-04-17 Eastman Chemical Company Amphoteric ester sulfonates
US9381147B2 (en) 2014-10-20 2016-07-05 Johnson & Johnson Consumer Inc. Compositions comprising zwitterionic ester ammonioalkanoates
US9533951B2 (en) 2014-10-20 2017-01-03 Eastman Chemical Company Heterocyclic amphoteric compounds
AU2016255504A1 (en) * 2015-04-29 2017-11-16 Sanford-Burnham Medical Research Institute Novel EphA4 inhibitors targeting its ligand binding domain
US9993408B2 (en) 2015-09-17 2018-06-12 Johnson & Johnson Consumer Inc. Compositions comprising zwitterionic alkyl-alkanoylamides and/or alkyl alkanoates
US11414380B2 (en) 2015-09-17 2022-08-16 Eastman Chemical Company Amphoteric compounds
WO2019165442A1 (en) * 2018-02-26 2019-08-29 Waters Technologies Corporation Acid labile surfactants and method for performing protein solubilization or enzyme digestion
TW202506105A (zh) * 2023-07-07 2025-02-16 大陸商上海詩健生物科技有限公司 連接子－藥物分子及抗體藥物偶聯物、其製備方法和應用
WO2025153055A1 (en) 2024-01-19 2025-07-24 Shanghai Escugen Biotechnology Co., Ltd. An anti_itga2 antibody drug conjugate

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871929A (en) 1974-01-30 1975-03-18 Allied Chem Polymeric etch resist strippers and method of using same
US4478598A (en) * 1981-02-26 1984-10-23 Ciba-Geigy Corporation Amphoteric styrene derivatives useful as fluorescent brighteners
EP0061872B1 (en) * 1981-03-30 1985-08-07 Takeda Chemical Industries, Ltd. Ethyleneglycol derivatives, their production and use
JPS5839651A (ja) 1981-09-04 1983-03-08 Ajinomoto Co Inc 新規ジアミノモノカルボン酸誘導体及びこれを活性成分とする界面活性剤
JPH0411075Y2 (enExample) 1985-09-13 1992-03-18
JPH0411073Y2 (enExample) 1986-03-07 1992-03-18
AU609824B2 (en) * 1987-06-15 1991-05-09 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
JPH0434078Y2 (enExample) 1987-08-21 1992-08-13
JPH01225494A (ja) * 1988-03-07 1989-09-08 Toukuri Lab:Kk 水不溶性融合蛋白質の可溶化方法
US5656426A (en) 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US4962024A (en) * 1988-08-11 1990-10-09 Becton, Dickinson And Company Signal enhancement in assay for an enzyme
JPH0434079Y2 (enExample) 1989-08-14 1992-08-13
US5418295A (en) * 1989-10-13 1995-05-23 Biocompatibles Limited Method of reducing protein deposition in sight correction devices
JPH043079A (ja) 1990-04-20 1992-01-08 Seiko Epson Corp 電子写真装置
JPH0434079A (ja) * 1990-04-24 1992-02-05 Nippon Shokubai Co Ltd 羊毛及び羊毛製品のセット加工用剤
JPH0434078A (ja) * 1990-04-25 1992-02-05 Nippon Shokubai Co Ltd 羊毛及び羊毛製品のセット加工用剤
JP2724022B2 (ja) * 1990-04-26 1998-03-09 株式会社日本触媒 繊維及び繊維製品の柔軟加工用剤
JP2724023B2 (ja) * 1990-04-27 1998-03-09 株式会社日本触媒 繊維及び繊維製品の抗菌加工用剤
US6017895A (en) * 1992-02-10 2000-01-25 Genzyme Corporation Oligonucleotides possessing zwitterionic moieties
US5760021A (en) * 1992-05-29 1998-06-02 The Procter & Gamble Company Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
WO1993025533A1 (en) 1992-06-05 1993-12-23 Abbott Laboratories Methods and reagents for the determination of immunosuppressive agents
US5656246A (en) 1995-10-30 1997-08-12 International Ecoscience, Inc. Contaminant destruction by oxidation processing via enhanced ozonation
JPH10730A (ja) 1996-06-17 1998-01-06 Toyo Ink Mfg Co Ltd 光反射フィルム
WO1998011906A1 (en) 1996-09-17 1998-03-26 Amur Pharmaceuticals, Inc. Phospholipid drug derivatives
JPH10158979A (ja) * 1996-11-20 1998-06-16 Matsushita Electric Ind Co Ltd 洗濯用仕上げ剤
US5830432A (en) * 1997-03-31 1998-11-03 Amur Pharmacuticals, Inc. Phospholipid drug derivatives
US20040146867A1 (en) 2003-01-24 2004-07-29 Slattum Paul M Compounds and processes for single-pot attachment of a label to siRNA
SE9803838D0 (sv) 1998-11-09 1998-11-09 Knut Irgum A chromatography method and a column material useful in said method
JP3437517B2 (ja) 1999-02-16 2003-08-18 キヤノン株式会社 二次元位相型光学素子の作製方法
JP3818001B2 (ja) * 1999-04-20 2006-09-06 コニカミノルタホールディングス株式会社 インクジェット記録用インク
JP2002052714A (ja) 2000-05-30 2002-02-19 Kyocera Corp インクジェット記録ヘッド
JP4706816B2 (ja) * 2001-09-28 2011-06-22 ライオン株式会社 液体柔軟剤組成物
EP1465933B1 (en) 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymer conjugates
AUPS298102A0 (en) * 2002-06-13 2002-07-04 Nucleics Pty Ltd Method for performing chemical reactions
US7582260B2 (en) 2002-07-18 2009-09-01 Montana State University Zwitterionic dyes for labeling in proteomic and other biological analyses
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7005518B2 (en) 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
DE10304219B3 (de) 2003-01-30 2004-08-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
DE10307725B4 (de) 2003-02-24 2007-04-19 Clariant Produkte (Deutschland) Gmbh Korrosions-und Gashydratinhibitoren mit verbesserter Wasserlöslichkeit und erhöhter biologischer Abbaubarkeit
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
DE102005051587A1 (de) * 2005-10-27 2007-05-03 Consortium für elektrochemische Industrie GmbH Zwitterionische Strukturelemente aufweisende Partikel
CN101415727A (zh) * 2006-04-07 2009-04-22 莫德普罗股份公司 C-反应蛋白的结合剂
EP2074101B1 (en) 2006-10-13 2012-08-08 Siemens Healthcare Diagnostics Inc. Stable acridinium esters with fast light emission
WO2008141012A2 (en) 2007-05-11 2008-11-20 Mpex Pharmaceuticals, Inc. Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof
WO2009067566A1 (en) * 2007-11-19 2009-05-28 University Of Washington Hemostatic wound dressings
US7745670B2 (en) 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
CN102762539B (zh) * 2009-11-16 2015-07-29 西门子医疗保健诊断公司 含两性离子的吖啶鎓化合物
US9487480B2 (en) * 2010-05-21 2016-11-08 Siemens Healthcare Diagnostics Inc. Zwitterionic reagents

Also Published As

Publication number Publication date
CN102905690A (zh) 2013-01-30
CN102905690B (zh) 2016-03-30
EP2571487A2 (en) 2013-03-27
JP6524272B2 (ja) 2019-06-05
US20160274094A1 (en) 2016-09-22
US9487480B2 (en) 2016-11-08
WO2011146595A3 (en) 2012-01-12
WO2011146595A2 (en) 2011-11-24
EP4183773A1 (en) 2023-05-24
US10710962B2 (en) 2020-07-14
EP2571487A4 (en) 2015-03-11
JP2013534909A (ja) 2013-09-09
US20130065325A1 (en) 2013-03-14
EP2571487B1 (en) 2023-01-04
JP2018080194A (ja) 2018-05-24

Similar Documents

Publication Publication Date Title
ES2941663T3 (es) Reactivos zwitteriónicos
ES2585364T3 (es) Compuestos de acridinio que contienen zwitteriones
US7875467B2 (en) Applications of acridinium compounds and derivatives in homogeneous assays
AU782559B2 (en) Acridinium ester labels having hydrophilic modifiers
CN101790684B (zh) 缀合物制备的改进或与缀合物制备相关的改进
EP0330050B1 (de) Spezielle chemilumineszierende Acridinderivate und ihre Verwendung in Lumineszenzimmunoassays
EP0606411B1 (en) Novel compounds and conjugates
Natrajan et al. Synthesis and properties of differently charged chemiluminescent acridinium ester labels
US20050255528A1 (en) Hydrophilic chemiluminescent acridinium labeling reagents
AU2014239248B2 (en) 6-Acetylmorphine analogs, and methods for their synthesis and use
CA1178269A (en) Fluorescent polarization immunoassay utilizing substituted carboxyfluoresceins
US20090318627A1 (en) Solid phase synthesis of acridinium derivatives
US8435800B2 (en) Activated labeling reagents and methods for preparing and using the same
Natrajan et al. Zwitterionic reagents for labeling, cross-linking and improving the performance of chemiluminescent immunoassays
US20040181043A1 (en) Precursor for biological probes and methods of its synthesis
HK1020276A (en) Assays utilizing improved chemiluminescent esters, thioesters and amides