ES2660249T3 - Compuestos de tipo triazolona y sus usos - Google Patents
Compuestos de tipo triazolona y sus usos Download PDFInfo
- Publication number
- ES2660249T3 ES2660249T3 ES13863783T ES13863783T ES2660249T3 ES 2660249 T3 ES2660249 T3 ES 2660249T3 ES 13863783 T ES13863783 T ES 13863783T ES 13863783 T ES13863783 T ES 13863783T ES 2660249 T3 ES2660249 T3 ES 2660249T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cycloalkyl
- halogen
- heteroaromatic ring
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- FFSJPOPLSWBGQY-UHFFFAOYSA-N triazol-4-one Chemical class O=C1C=NN=N1 FFSJPOPLSWBGQY-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I**Fórmula** o una sal farmacéuticamente aceptable de este donde: A1 es un anillo fenilo o un anillo heteroaromático de 6 miembros que tiene 1, 2 o 3 N en el anillo heteroaromático; A2 se selecciona entre A2a o A2b**Fórmula** donde A2a es un anillo fenilo o un anillo heteroaromático de 6 miembros que tiene 1, 2 o 3 N en el anillo heteroaromático, y A2b es un anillo heteroaromático de 5 miembros que tiene 1, 2 o 3 heteroátomos seleccionados de manera independiente entre O, S y N; X se selecciona a partir del grupo constituido por -(CH2)2-, -(CH2)3-, -(CH2)4-, y -(CH2)m-O-(CH2)n-, mono- o disustituido de manera opcional con halógeno, donde m y n son de manera independiente 0, 1, 2, 3 o 4, siempre que m+n sea 2, 3 o 4; Y es O; R1 y R2 se seleccionan cada uno de manera independiente a partir del grupo constituido por: (a) hidrógeno, (b) halógeno, (c) CN, (d) CF3, (e) -alquilo C1-6, (f) -(alquilo C1-6)-C(>=O)OH, (g) -O-(R7), (h) -S(>=O)oR7, (i) -N(R7)(R8), (j) -N(R7)-C(>=O)-(R8), (k) -N(R7)-C(>=O)-O-(R8), (l) -N(R7)S(>=O)2(R8), (m) -(cicloalquilo C3-6), (n) -C(>=O)(R7), (o) arilo, (p) heteroarilo, (q) -OC(>=O)N(R7)(R8), (r) -S(>=O)2N(R7)(R8), (s) -C(>=O)N(R7)(R8) y (t) -C(R7)(R8)OH, donde la porción alquilo de las opciones (e) y (f), y la porción cicloalquilo de la opción (m) están sustituidas de manera opcional con halógeno, y donde el arilo de la opción (o) y el heteroarilo de la opción (p) están mono- o disustituidos de manera opcional con sustituyentes seleccionados entre halógeno, nitro, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, cicloalquilo C3-6, cicloalcoxi C3-6, -NH(alquilo C1-6), -NH(cicloalquilo C3-6), -N(alquilo C1-6)2, -N(cicloalquilo C3-6)2, -S(>=O)o(alquilo C1-6), - S(>=O)o(cicloalquilo C3-6) y CN; R3 se selecciona a partir del grupo constituido por: (a) hidrógeno, (b) halógeno, (c) CN, (d) CF3, (e) -alquilo C1-6, (f) -(alquilo C1-6)-C(>=O)OH, (g) -O-(R7), (h) -S(>=O)oR7 (i) -N(R7)(R8), (j) -N(R7)-C(>=O)-(R8), (k) -N(R7)-C(>=O)-O-(R8), (l) -N(R7)S(>=O)2(R8), (m) -(cicloalquilo C3-6), (n) -C(>=O)(R7), (o) arilo, (p) heteroarilo, (q) -OC(>=O)N(R7)(R8), (r) -S(>=O)2N(R7)(R8), (s) -C(>=O)N(R7)(R8), (t) -C(R7)(R8)OH, (u) -NHC(>=O)-N(R7)(R8), (v) -(cicloalquil C3-6)-COOH, (w) heterociclo y (x) -(alquil C1-6)C(>=O)-N(R7)(R8), donde la porción alquilo de las opciones (e), (f) y (x), y la porción cicloalquilo de las opciones (m) y (v) están sustituidas de manera opcional con halógeno o hidroxilo, y
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261739906P | 2012-12-20 | 2012-12-20 | |
PCT/US2013/074197 WO2014099503A1 (en) | 2012-12-20 | 2013-12-10 | Triazolone compounds and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2660249T3 true ES2660249T3 (es) | 2018-03-21 |
Family
ID=50979036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13863783T Active ES2660249T3 (es) | 2012-12-20 | 2013-12-10 | Compuestos de tipo triazolona y sus usos |
Country Status (18)
Country | Link |
---|---|
US (4) | US9676754B2 (es) |
EP (1) | EP2935228B9 (es) |
JP (1) | JP6404230B2 (es) |
KR (1) | KR102300675B1 (es) |
CN (1) | CN104918922B (es) |
AU (1) | AU2013363398B2 (es) |
BR (1) | BR112015013350B1 (es) |
CA (1) | CA2894281C (es) |
DK (1) | DK2935228T3 (es) |
EA (1) | EA027986B9 (es) |
ES (1) | ES2660249T3 (es) |
HK (1) | HK1212680A1 (es) |
IL (1) | IL239372B (es) |
MX (1) | MX2015007433A (es) |
NO (1) | NO3003327T3 (es) |
PE (1) | PE20151521A1 (es) |
SG (1) | SG11201504622PA (es) |
WO (1) | WO2014099503A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104918922B (zh) | 2012-12-20 | 2017-04-26 | 因森普深2公司 | 三唑酮化合物及其用途 |
CN105579440A (zh) * | 2013-09-06 | 2016-05-11 | 因森普深2公司 | 三唑酮化合物及其应用 |
WO2022052982A1 (zh) * | 2020-09-14 | 2022-03-17 | 昭明泽康(北京)生物医药科技有限公司 | PPARα(过氧化物酶体增殖物激活受体α)配体在制备药物中的应用 |
Family Cites Families (139)
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